Arthritis and Joint Replacement

Vasculitis

Vasculitis is a general term for a group of diseases, approximately 20 different disorders, that involve inflammation in the blood vessels. Although these diseases are similar in some ways, they vary depending on which organs are affected. Blood vessels of all sizes may be affected. When blood vessels become inflamed, they can become weakened, stretch and increase in size, causing an aneurysm. At other times, they may become inflamed and narrowed, partially or completely eliminating blood supply to tissues. If other blood vessels are not able to carry blood to that area, the tissue will die.

Symptoms of vasculitis differ depending on the blood vessels involved. However, many patients with vasculitis feel sick and experience fevers, weight loss, fatigue, a rapid pulse, and a range of aches and pains that are difficult to pinpoint. In addition to these symptoms, vasculitis may affect virtually every organ system in the body, including the skin, joints, lungs, kidneys, gastrointestinal tract, blood, sinuses, nose and ears, eyes, brain and nerves.

The causes of most forms of vasculitis are unknown. However, it has been shown that the immune system plays a critical role in the tissue damage caused by vasculitis. Vasculitis also may be related to other diseases of the immune system, such as rheumatoid arthritis, systemic lupus or Sjögren's syndrome.

Treatment depends upon the type of vasculitis and the organs affected. Such treatment usually includes medications that suppress parts of the immune system. Examples include cyclophosphamide, azathioprine, methotrexate and prednisone. These medications can cause many side effects and should be discussed in detail with your doctor.

For more information or to make an appointment, please call:
Rheumatology Clinic (415) 353-2497

Reviewed by health care specialists at UCSF Medical Center.
Last updated August 29, 2007