Cirrhosis

Signs and Symptoms

Many people with cirrhosis do not experience any symptoms in the early stages of the disease. However, as scar tissue replaces healthy cells, liver function may begin to fail, causing the following symptoms.

• Development of spider-like red spots on the chest, face or arms
• Fatigue
• Loss of appetite
• Nausea
• Weakness
• Weight loss

• Difficulty concentrating
• Impaired sleep
• Poor memory
• Accumulation of fluid in the abdomen and/or legs
• Yellowish color of the skin and eyes (jaundice)
• Dark urine
• Weakness and decreased muscle mass
• Gastrointestinal bleeding
• Coma, in severe cases

Diagnosis

Cirrhosis may be diagnosed based on your symptoms, medical history, physical examination and results of laboratory tests. Tests to confirm a diagnosis of cirrhosis include a complete blood count (CBC), liver enzyme, liver function and electrolyte testing as well as screening for other health conditions such as hepatitis B and C viruses, liver cancer or gallstones.

In most cases, a liver biopsy is used to confirm the diagnosis. During a biopsy, the doctor uses a needle to take a small sample of tissue from your liver so that it can be examined for scarring or other signs of disease.

Imagining tests may also be recommended to obtain a closer look at your liver. These include a computerized tomography (CT) scan, ultrasound or a scan of the liver using a radioisotope -- a harmless radioactive substance that highlights the liver. The doctor also might examine your liver using a laparoscope, an instrument that is inserted through the abdomen that relays images onto a computer screen.

Treatment

Treatment of cirrhosis focuses on stopping or delaying the damage to your liver and preventing complications, such as liver failure. When the cause of the condition is known, therapy will aim to specifically manage that illness. For instance, if a patient has hepatitis, the doctor may administer steroids or antiviral drugs for treatment.

Regardless of the cause of cirrhosis, it is essential that every patient avoid all substances, habits and drugs that may further damage the liver or cause complications or liver failure. Alcohol, in addition to causing cirrhosis, may accelerate the progression of liver scarring. All patients with liver disease should not drink any alcohol. Medications also may be given to control the symptoms of cirrhosis.

If complications progress to the point of possible liver failure, a liver transplant may be recommended. Our team of digestive disorder experts work closely with liver transplant specialists at UCSF Medical Center, who can provide excellent care. Liver failure may occur at the end stage of liver disease when the liver stops working and cannot support life. Liver failure is difficult to treat and survival is limited. However, the good news is that many people with cirrhosis have undergone successful liver transplants. Also, many patients live long and healthy lives with other means of therapy.