Huntington's Disease

Huntington's disease (HD) is a fatal condition typically characterized by involuntary movements and dementia. The disease is caused by genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This causes uncontrolled movements, loss of intellectual faculties and emotional disturbance. The disease is a hereditary disorder passed on by a parent to child through a mutation in a gene.

In the United States, Huntington's disease occurs in about one of every 10,000 to 20,000 persons, affects males and females equally and crosses all ethnic and racial boundaries. Typically, symptoms begin between age 30 and 55. Symptoms appear in children in about 10 percent of families and children who develop the juvenile form of the disease rarely live to adulthood.

Each child of a parent with Huntington's disease has a 50 percent chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it on to subsequent generations. A person who inherits the HD gene will eventually develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. In 1 percent to 3 percent of individuals with HD, there is no family history of HD.

At this time, there is no known cure or treatment to reverse the course of the disease. Currently, UCSF specialists are studying the Huntington's disease gene to better understand how to treat the condition.

See books recommended by the UCSF Memory and Aging Center.

Reviewed by health care specialists at UCSF Medical Center.
Last updated February 8, 2008