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J. Blake Tyrrell, M.D.


Dr. J. Blake Tyrrell is an endocrinologist who specializes in treating adrenal disease and pituitary disease. He received his medical degree from the University of Toronto's Faculty of Medicine. Tyrrell did his residency training in internal medicine at the University of California, San Francisco, where he also completed a fellowship in endocrinology. Tyrrell is board certified in internal medicine as well as endocrinology and metabolism.


California Center for Pituitary Disorders
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (866) 559-5543
or (415) 353-7500
Fax: (415) 353-2889

Hours: Monday to Friday
8 a.m. – 5 p.m.

Endocrinology Clinic at Parnassus
400 Parnassus Ave., Suite A-550
San Francisco, CA 94143
Phone: (415) 353–2350
Fax: (415) 353–2337

Hours: Monday to Friday, 8:30 a.m. – 5 pm.

Conditions & Treatments

More about J. Blake Tyrrell


University of Toronto 1966


UCSF, Internal Medicine 1969


UCSF, Endocrinology 1975

Selected Research and Publications

  1. Potts MB, Shah JK, Molinaro AM, Blevins LS, Tyrrell JB, Kunwar S, Dowd CF, Hetts SW, Aghi MK. Cavernous and inferior petrosal sinus sampling and dynamic magnetic resonance imaging in the preoperative evaluation of Cushing's disease. J Neurooncol. 2014 Feb; 116(3):593-600.
  2. Scholten A, Cisco RM, Vriens MR, Cohen JK, Mitmaker EJ, Liu C, Tyrrell JB, Shen WT, Duh QY. Pheochromocytoma crisis is not a surgical emergency. J Clin Endocrinol Metab. 2013 Feb; 98(2):581-91.
  3. Chang EF, Zada G, Kim S, Lamborn KR, Quinones-Hinojosa A, Tyrrell JB, Wilson CB, Kunwar S. Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas. J Neurosurg. 2008 Apr; 108(4):736-45.
  4. Liu C, Lo JC, Dowd CF, Wilson CB, Kunwar S, Aron DC, Tyrrell JB. Cavernous and inferior petrosal sinus sampling in the evaluation of ACTH-dependent Cushing's syndrome. Clin Endocrinol (Oxf). 2004 Oct; 61(4):478-86.
  5. Liu C, Tyrrell JB. Successful treatment of a large macroprolactinoma with cabergoline during pregnancy. Pituitary. 2001 Aug; 4(3):179-85.
  6. Lo JC, Schwitzgebel VM, Tyrrell JB, Fitzgerald PA, Kaplan SL, Conte FA, Grumbach MM. Normal female infants born of mothers with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metab. 1999 Mar; 84(3):930-6.
  7. Tyrrell JB, Lamborn KR, Hannegan LT, Applebury CB, Wilson CB. Transsphenoidal microsurgical therapy of prolactinomas: initial outcomes and long-term results. Neurosurgery. 1999 Feb; 44(2):254-61; discussion 261-3.
  8. Abosch A, Tyrrell JB, Lamborn KR, Hannegan LT, Applebury CB, Wilson CB. Transsphenoidal microsurgery for growth hormone-secreting pituitary adenomas: initial outcome and long-term results. J Clin Endocrinol Metab. 1998 Oct; 83(10):3411-8.
  9. Loh KC, Fitzgerald PA, Miller TR, Tyrrell JB. Perils and pitfalls in the diagnosis of Cushing's syndrome. West J Med. 1998 Jul; 169(1):46-50.
  10. Loh KC, Green A, Dillon WP, Fitzgerald PA, Weidner N, Tyrrell JB. Diabetes insipidus from sarcoidosis confined to the posterior pituitary. Eur J Endocrinol. 1997 Nov; 137(5):514-9.
  11. Mamelak AN, Dowd CF, Tyrrell JB, McDonald JF, Wilson CB. Venous angiography is needed to interpret inferior petrosal sinus and cavernous sinus sampling data for lateralizing adrenocorticotropin-secreting adenomas. J Clin Endocrinol Metab. 1996 Feb; 81(2):475-81.
  12. Taylor SL, Tyrrell JB, Wilson CB. Delayed onset of hyponatremia after transsphenoidal surgery for pituitary adenomas. Neurosurgery. 1995 Oct; 37(4):649-53; discussion 653-4.
  13. Fitzgerald PJ, Ports TA, Cheitlin MD, Magilligan DJ, Tyrrell JB. Intracardiac pheochromocytoma with dual coronary blood supply: case report and literature review. Cardiovasc Surg. 1995 Oct; 3(5):557-61.
  14. Wilson CB, Mindermann T, Tyrrell JB. Extrasellar, intracavernous sinus adrenocorticotropin-releasing adenoma causing Cushing's disease. J Clin Endocrinol Metab. 1995 Jun; 80(6):1774-7.
  15. Tyrrell JB, Wilson CB. Cushing's disease. Therapy of pituitary adenomas. Endocrinol Metab Clin North Am. 1994 Dec; 23(4):925-38.
  16. Baxter JD, Tyrrell JB. Evaluation of the hypothalamic-pituitary-adrenal axis: importance in steroid therapy, AIDS, and other stress syndromes. Adv Intern Med. 1994; 39:667-96.
  17. Contreras LN, Budd D, Yen TS, Thomas C, Tyrrell JB. Adrenal ganglioneuroma-pheochromocytoma secreting vasoactive intestinal polypeptide. West J Med. 1991 Mar; 154(3):334-7.
  18. Mampalam TJ, Tyrrell JB, Wilson CB. Transsphenoidal microsurgery for Cushing disease. A report of 216 cases. Ann Intern Med. 1988 Sep 15; 109(6):487-93.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.