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Bruce L. Miller, M.D.

Behavioral neurologist

Dr. Bruce L. Miller directs the UCSF dementia center. His goal is to ensure the delivery of model care to all patients who enter the clinical and research programs at the UCSF Memory and Aging Center.

Miller's focus is dementia, with special interest in brain and behavior relationships as well as the genetic and molecular underpinnings of disease. His work in frontotemporal dementia (FTD) emphasizes both the behavioral and emotional deficits that characterize these patients, while simultaneously noting the visual creativity that can emerge in patients with FTD. He is the principal investigator of the Alzheimer's Disease Research Center, sponsored by the National Institutes of Health (NIH), as well as an NIH-funded project on FTD called Frontotemporal Dementia: Genes, Imaging and Emotions. Miller oversees a healthy aging program supported through the Larry H. Hillblom Foundation and the Hellman Center, which includes an artist in residence program. In addition, he helps lead two philanthropy-funded research consortia, the Tau Consortium and Consortium for Frontotemporal Research, focused around developing treatments for tau and progranulin disorders.

Miller has received many awards including the Potamkin Award from the American Academy of Neurology, the Raymond Adams Lecture at the American Neurological Association, the Elliot Royer Award from the San Francisco neurological community, the UCSF Annual Faculty Research Lectureship in Clinical Science, the UCSF Academic Senate Distinction in Mentoring Award, and the Gene D. Cohen Research Award in Creativity and Aging from the National Center for Creative Aging.

Miller is author of The Human Frontal Lobes, The Behavioral Neurology of Dementia, and extensive publications about dementia. He has been featured in Fortune Magazine, The Charlie Rose Show, PBS NewsHour, The New York Times and other media. For nearly three decades, Miller has been the scientific director for the philanthropic organization, The John Douglas French Alzheimer's Foundation.

Clinics

Concussion and Brain Injury Program
1500 Owens St., Second Floor
San Francisco, CA 94158
Phone: (415) 353-1915
Fax: (415) 514-6075

Hours: Monday to Friday
8 a.m. – 5 p.m.

Memory and Aging Center
1500 Owens St., Suite 320
San Francisco, CA 94158
Phone: (415) 476-6880
Fax: (415) 476-4800

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

More about Bruce L. Miller

Additional Languages

French
Spanish

Education

University of British Columbia 1978

Residencies

Vancouver General Hospital, Internal Medicine 1980
University of Western Ontario, Neurology 1981
UCLA, Neurology 1983

Fellowships

UCLA, Pharmacology 1985
UCLA, Neurobehavior 1985

Selected Research and Publications

  1. Arnold SE, Toledo JB, Appleby DH, Xie SX, Wang LS, Baek Y, Wolk DA, Lee EB, Miller BL, Lee VM, Trojanowski JQ. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. J Comp Neurol. 2013 Dec 15; 521(18):4339-55.
  2. Perry DC, Miller BL. Frontotemporal dementia. Semin Neurol. 2013 Sep; 33(4):336-41.
  3. Gorno-Tempini ML, Miller BL. Primary Progressive Aphasia as a model to study the neurobiology of language. Brain Lang. 2013 Nov; 127(2):105.
  4. Bettcher BM, Walsh CM, Watson C, Miller JW, Green R, Patel N, Miller BL, Neuhaus J, Yaffe K, Kramer JH. Body mass and white matter integrity: the influence of vascular and inflammatory markers. PLoS One. 2013; 8(10):e77741.
  5. Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV, Moore MJ, Shaw CE, Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013; 8(10):e76055.
  6. Geschwind MD, Kuo AL, Wong KS, Haman A, Devereux G, Raudabaugh BJ, Johnson DY, Torres-Chae CC, Finley R, Garcia P, Thai JN, Cheng HQ, Neuhaus JM, Forner SA, Duncan JL, Possin KL, Dearmond SJ, Prusiner SB, Miller BL. Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease. Neurology. 2013 Dec 3; 81(23):2015-23.
  7. Guo CC, Gorno-Tempini ML, Gesierich B, Henry M, Trujillo A, Shany-Ur T, Jovicich J, Robinson SD, Kramer JH, Rankin KP, Miller BL, Seeley WW. Anterior temporal lobe degeneration produces widespread network-driven dysfunction. Brain. 2013 Oct; 136(Pt 10):2979-91.
  8. Lee SE, Tartaglia MC, Yener G, GenÁ S, Seeley WW, Sanchez-Juan P, Moreno F, Mendez MF, Klein E, Rademakers R, Munain AL, Combarros O, Kramer JH, Kenet RO, Boxer AL, Geschwind MD, Gorno-Tempini ML, Karydas AM, Rabinovici GD, Coppola G, Geschwind DH, Miller BL. Neurodegenerative Disease Phenotypes in Carriers of MAPT p.A152T, A Risk Factor for Frontotemporal Dementia Spectrum Disorders and Alzheimer Disease. Alzheimer Dis Assoc Disord. 2013 Oct-Dec; 27(4):302-9.
  9. Freedman M, Binns MA, Black SE, Levine B, Miller BL, Ramirez J, Szilagyi GM, Scott CJ, McNeely AA, Stuss DT. Object alternation: a novel probe of medial frontal function in frontotemporal dementia. Alzheimer Dis Assoc Disord. 2013 Oct-Dec; 27(4):316-23.
  10. Miller ZA, Mandelli ML, Rankin KP, Henry ML, Babiak MC, Frazier DT, Lobach IV, Bettcher BM, Wu TQ, Rabinovici GD, Graff-Radford NR, Miller BL, Gorno-Tempini ML. Handedness and language learning disability differentially distribute in progressive aphasia variants. Brain. 2013 Nov; 136(Pt 11):3461-73.
  11. Leutwyler H, Hubbard EM, Jeste DV, Miller B, Vinogradov S. Associations of schizophrenia symptoms and neurocognition with physical activity in older adults with schizophrenia. Biol Res Nurs. 2014 Jan; 16(1):23-30.
  12. van Blitterswijk M, Baker MC, DeJesus-Hernandez M, Ghidoni R, Benussi L, Finger E, Hsiung GY, Kelley BJ, Murray ME, Rutherford NJ, Brown PE, Ravenscroft T, Mullen B, Ash PE, Bieniek KF, Hatanpaa KJ, Karydas A, Wood EM, Coppola G, Bigio EH, Lippa C, Strong MJ, Beach TG, Knopman DS, Huey ED, Mesulam M, Bird T, White CL, Kertesz A, Geschwind DH, Van Deerlin VM, Petersen RC, Binetti G, Miller BL, Petrucelli L, Wszolek ZK, Boylan KB, Graff-Radford NR, Mackenzie IR, Boeve BF, Dickson DW, Rademakers R. C9ORF72 repeat expansions in cases with previously identified pathogenic mutations. Neurology. 2013 Oct 8; 81(15):1332-41.
  13. Miller BL. Refining the clinical presentation of the C9ORF72 hexanucleotide repeat expansion. Biol Psychiatry. 2013 Sep 1; 74(5):320.
  14. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013 Sep 1; 70(9):1158-66.
  15. Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y. Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(3):226-34.
  16. Heuer HW, Mirsky JB, Kong EL, Dickerson BC, Miller BL, Kramer JH, Boxer AL. Antisaccade task reflects cortical involvement in mild cognitive impairment. Neurology. 2013 Oct 1; 81(14):1235-43.
  17. Henry ML, Rising K, Demarco AT, Miller BL, Gorno-Tempini ML, Beeson PM. Examining the value of lexical retrieval treatment in primary progressive aphasia: Two positive cases. Brain Lang. 2013 Nov; 127(2):145-56.
  18. Possin KL, Kang GA, Guo C, Fine EM, Trujillo AJ, Racine CA, Wilheim R, Johnson ET, Witt JL, Seeley WW, Miller BL, Kramer JH. Rivastigmine is associated with restoration of left frontal brain activity in Parkinson's disease. Mov Disord. 2013 Sep; 28(10):1384-90.
  19. Almeida S, Gascon E, Tran H, Chou HJ, Gendron TF, Degroot S, Tapper AR, Sellier C, Charlet-Berguerand N, Karydas A, Seeley WW, Boxer AL, Petrucelli L, Miller BL, Gao FB. Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons. Acta Neuropathol. 2013 Sep; 126(3):385-99.
  20. Lykou E, Rankin KP, Chatziantoniou L, Boulas C, Papatriantafyllou O, Tsaousis I, Neuhaus J, Karageorgiou C, Miller BL, Papatriantafyllou JD. Big 5 personality changes in Greek bvFTD, AD, and MCI patients. Alzheimer Dis Assoc Disord. 2013 Jul-Sep; 27(3):258-64.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.