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Bruce L. Miller, M.D.

Behavioral neurologist

Dr. Bruce L. Miller, a behavioral neurologist, is clinical director of the UCSF Memory and Aging Center, which treats patients with diseases that cause dementia such as Alzheimer's disease, corticobasal degeneration, Creutzfeldt-Jakob disease and frontotemporal dementia. Miller directs a program that links comprehensive patient evaluations to basic research in neuropsychology, neuropsychiatry, neuroimaging and genetics. The UCSF Memory and Aging Center sees about 400 new patients a year and follows many of these patients for the rest of their lives.

Miller has more than a decade of experience with pharmaceutical trials for Alzheimer's disease. He has a special interest in frontotemporal dementia and has organized research studies into a large resource of information involving these patients. Miller is the author of a book titled "The Human Frontal Lobes." His work has been published in many journals including Neurology, Archives of Neurology, Journal of International Neuropsychological Society, Brain and Lancet. He is a professor of neurology and psychiatry at the University of California, San Francisco, where he holds the A.W. & Mary Margaret Clausen Distinguished Chair.

Conditions & Treatments

Clinics

Memory and Aging Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 476-6880
Fax: (415) 476-4800

Hours: Monday to Friday
8 a.m. – 5 p.m.

More about Bruce L. Miller

Additional Languages

French
Spanish

Education

University of British Columbia 1978

Residencies

Vancouver General Hospital, Internal Medicine 1980

Fellowships

University of Western Ontario, Neurology 1981

Selected Research and Publications

  1. Tartaglia MC, Johnson DY, Thai JN, Cattaruzza T, Wong K, Garcia P, Dearmond SJ, Miller BL, Geschwind MD. Clinical Overlap between Jakob-Creutzfeldt Disease and Lewy Body Disease. Can J Neurol Sci. 2012 May; 39(3):304-10.
  2. Boxer AL, Garbutt S, Seeley WW, Jafari A, Heuer HW, Mirsky J, Hellmuth J, Trojanowski JQ, Huang E, Dearmond S, Neuhaus J, Miller BL. Saccade abnormalities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer disease. Arch Neurol. 2012 Apr; 69(4):509-17.
  3. Khan BK, Yokoyama JS, Takada LT, Sha SJ, Rutherford NJ, Fong JC, Karydas AM, Wu T, Ketelle RS, Baker MC, Hernandez MD, Coppola G, Geschwind DH, Rademakers R, Lee SE, Rosen HJ, Rabinovici GD, Seeley WW, Rankin KP, Boxer AL, Miller BL. Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion. J Neurol Neurosurg Psychiatry. 2012 Apr; 83(4):358-64.
  4. Zhou J, Gennatas ED, Kramer JH, Miller BL, Seeley WW. Predicting regional neurodegeneration from the healthy brain functional connectome. Neuron. 2012 Mar 22; 73(6):1216-27.
  5. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 6; 109(10):3985-90.
  6. Khan BK, Woolley JD, Chao S, See T, Karydas AM, Miller BL, Rankin KP. Schizophrenia or neurodegenerative disease prodrome? Outcome of a first psychotic episode in a 35-year-old woman. Psychosomatics. 2012 May; 53(3):280-4.
  7. Eckart JA, Sturm VE, Miller BL, Levenson RW. Diminished disgust reactivity in behavioral variant frontotemporal dementia. Neuropsychologia. 2012 Apr; 50(5):786-90.
  8. Rabinovici GD, Miller BL. Corticobasal syndrome: overcoming the artificial divide between disorders of cognition and movement. J Neurol Neurosurg Psychiatry. 2012 Apr; 83(4):404.
  9. Olney NT, Goodkind MS, Lomen-Hoerth C, Whalen PK, Williamson CA, Holley DE, Verstaen A, Brown LM, Miller BL, Kornak J, Levenson RW, Rosen HJ. Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis. Brain. 2011 Dec; 134(Pt 12):3455-66.
  10. Wilson SM, Galantucci S, Tartaglia MC, Rising K, Patterson DK, Henry ML, Ogar JM, DeLeon J, Miller BL, Gorno-Tempini ML. Syntactic processing depends on dorsal language tracts. Neuron. 2011 Oct 20; 72(2):397-403.
  11. Tosun D, Rosen H, Miller BL, Weiner MW, Schuff N. MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia. Neuroimage. 2012 Feb 1; 59(3):2098-109.
  12. DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, Seeley WW, Josephs KA, Coppola G, Geschwind DH, Wszolek ZK, Feldman H, Knopman DS, Petersen RC, Miller BL, Dickson DW, Boylan KB, Graff-Radford NR, Rademakers R. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 2011 Oct 20; 72(2):245-56.
  13. Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M. Perioperative cognitive decline in the aging population. Mayo Clin Proc. 2011 Sep; 86(9):885-93.
  14. Rankin KP, Mayo MC, Seeley WW, Lee S, Rabinovici G, Gorno-Tempini ML, Boxer AL, Weiner MW, Trojanowski JQ, Dearmond SJ, Miller BL. Behavioral Variant Frontotemporal Dementia with Corticobasal Degeneration Pathology: Phenotypic Comparison to bvFTD with Pick's Disease. J Mol Neurosci. 2011 Nov; 45(3):594-608.
  15. Heflin LH, Laluz V, Jang J, Ketelle R, Miller BL, Kramer JH. Let's inhibit our excitement: the relationships between Stroop, behavioral disinhibition, and the frontal lobes. Neuropsychology. 2011 Sep; 25(5):655-65.
  16. Damoiseaux JS, Prater KE, Miller BL, Greicius MD. Functional connectivity tracks clinical deterioration in Alzheimer's disease. Neurobiol Aging. 2012 Apr; 33(4):828.e19-30.
  17. Bettcher BM, Wilheim R, Rigby T, Green R, Miller JW, Racine CA, Yaffe K, Miller BL, Kramer JH. C-reactive protein is related to memory and medial temporal brain volume in older adults. Brain Behav Immun. 2012 Jan; 26(1):103-8.
  18. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011 Sep; 134(Pt 9):2456-77.
  19. Lee SE, Rabinovici GD, Mayo MC, Wilson SM, Seeley WW, DeArmond SJ, Huang EJ, Trojanowski JQ, Growdon ME, Jang JY, Sidhu M, See TM, Karydas AM, Gorno-Tempini ML, Boxer AL, Weiner MW, Geschwind MD, Rankin KP, Miller BL. Clinicopathological correlations in corticobasal degeneration. Ann Neurol. 2011 Aug; 70(2):327-40.
  20. Douglas VC, Neuhaus J, Johnson JK, Racine CA, Miller BL, Josephson SA. Dementia=(MC)2: a 4-item screening test for mild cognitive impairment and dementia. Alzheimer Dis Assoc Disord. 2011 Jul-Sep; 25(3):220-4.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.