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Carolyn S. Calfee, M.D.

Pulmonologist

Dr. Carolyn Calfee cares for patients in the intensive care units at UCSF Medical Center. She is also a member of UCSF's Center for Tobacco Control Research and Education and an associate member of the UCSF Cancer Center.

Calfee's primary research focus is the prevention, diagnosis, prognosis and treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Her current research projects include the role of biomarkers in investigating ALI/ARDS pathogenesis, early diagnosis, treatment and prognosis; the role of cigarette smoke exposure in susceptibility to lung injury; and novel treatments for acute lung injury.

Calfee received her undergraduate degree from Yale University and her medical degree from the University of Pennsylvannia School of Medicine. She came to UCSF for residency in internal medicine, and stayed to complete her chief residency and pulmonary/critical care medicine fellowship. She also completed a master's degree in clinical research at UCSF in 2009. After research training with Dr Michael Matthay and Dr. Mark Eisnere, she joined the UCSF faculty in 2007. She is an associate professor in residence of medicine and anesthesia.

More about Carolyn S. Calfee

Additional Languages

French

Education

University of Pensylvannia School of Medicine 1999

Residencies

UCSF Medical Center, Internal Medicine 2002

Fellowships

UCSF Medical Center, Pulmonary Medicine 2007

Selected Research and Publications

  1. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB. Distinct Molecular Phenotypes of Direct vs Indirect ARDS in Single-Center and Multicenter Studies. Chest. 2015 Jun 1; 147(6):1539-48.
  2. Howard BM, Kornblith LZ, Hendrickson CM, Redick BJ, Conroy AS, Nelson MF, Callcut RA, Calfee CS, Cohen MJ. Differences in degree, differences in kind: Characterizing lung injury in trauma. J Trauma Acute Care Surg. 2015 Apr; 78(4):735-41.
  3. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers AJ, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. Increased Expression Of Neutrophil-Related Genes In Patients With Early Sepsis-Induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 20; ajplung.00380.2014.
  4. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. Erratum to: Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574.
  5. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8.
  6. Moazed F, Calfee CS. Clearing the air. Smoking and incident asthma in adults. Am J Respir Crit Care Med. 2015 Jan 15; 191(2):123-4.
  7. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Jan; 3(1):24-32.
  8. Ware LB, Bastarache JA, Calfee CS. ARDS: New Mechanistic Insights, New Therapeutic Directions. Clin Chest Med. 2014 Dec; 35(4):xv-xvi.
  9. Moazed F, Calfee CS. Environmental risk factors for acute respiratory distress syndrome. Clin Chest Med. 2014 Dec; 35(4):625-37.
  10. Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS. Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Crit Care Med. 2014 Sep; 42(9):2058-68.
  11. Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS. Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs. Am J Transplant. 2014 Oct; 14(10):2295-302.
  12. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK. Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L435-48.
  13. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22.
  14. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS. Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. J Intensive Care. 2014; 2:40.
  15. Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM. Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1520-9.
  16. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med. 2014 Aug; 2(8):611-20.
  17. Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. J Crit Care. 2014 Oct; 29(5):718-22.
  18. Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB. Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Ann Intensive Care. 2014; 4(1):4.
  19. Kornblith LZ, Kutcher ME, Redick BJ, Calfee CS, Vilardi RF, Cohen MJ. Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis. J Trauma Acute Care Surg. 2014 Feb; 76(2):255-6; discussion 262-3.
  20. Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med. 2014 Mar; 40(3):388-96.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.