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Home > Doctors > Anthony Wynshaw-Boris

Anthony Wynshaw-Boris, M.D., Ph.D.

Pediatric medical geneticist

Dr. Anthony Wynshaw-Boris is chief of Medical Genetics at UCSF Benioff Children's Hospital. He specializes in the treatment of genetic and metabolic disorders, including birth defects, mental retardation, familial heart disease, neurologic disorders and cancer.

Wynshaw-Boris earned a medical degree at Case Western Reserve University in Cleveland, Ohio. He completed a residency at the Rainbow Babies and Children's Hospital in Cleveland and a fellowship at Children's Hospital of Boston. In his research, he is interested in developmental neurogenetics and autism. He is a member of medical and scientific organizations including the American Society of Clinical Investigation, American Pediatric Society and Association of American Physicians. He is president of the Association of Professors of Human and Medical Genetics and a member of the board of directors of the American Society of Human Genetics. Wynshaw-Boris is a professor of pediatrics at UCSF.

Clinics

General Genetics Clinic
400 Parnassus Ave., Second Floor
San Francisco, CA 94143
Phone: (415) 476-2757
Fax: (415) 476-9305

Hours: Tuesday and Thursday mornings (except first Tuesday of the month which is an all-day clinic)

Neurometabolic Clinic
400 Parnassus Ave., 2nd Floor
San Francisco, CA 94143-0748
Phone: (415) 476-9997
Fax: (415) 476-9976

Hours: Monday to Friday
8 a.m. – 5 p.m.

More about Anthony Wynshaw-Boris

Education

Case Western Reserve School of Medicine 1987

Residencies

Rainbow Babies and Children's Hospital 1989

Fellowships

Children's Hospital of Boston, Genetics 1994

Selected Research and Publications

  1. Toba S, Tamura Y, Kumamoto K, Yamada M, Takao K, Hattori S, Miyakawa T, Kataoka Y, Azuma M, Hayasaka K, Amamoto M, Tominaga K, Wynshaw-Boris A, Wanibuchi H, Oka Y, Sato M, Kato M, Hirotsune S. Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly. Sci Rep. 2013; 3:1224.
  2. Huang X, McGann JC, Liu BY, Hannoush RN, Lill JR, Pham V, Newton K, Kakunda M, Liu J, Yu C, Hymowitz SG, Hongo JA, Wynshaw-Boris A, Polakis P, Harland RM, Dixit VM. Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. Science. 2013 Mar 22; 339(6126):1441-5.
  3. Sebe JY, Bershteyn M, Hirotsune S, Wynshaw-Boris A, Baraban SC. ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice. J Neurophysiol. 2013 Jan; 109(2):429-36.
  4. Kosaka Y, Cieslik KA, Li L, Lezin G, Maguire CT, Saijoh Y, Toyo-Oka K, Gambello MJ, Vatta M, Wynshaw-Boris A, Baldini A, Yost HJ, Brunelli L. 14-3-3{varepsilon} Plays a Role in Cardiac Ventricular Compaction by Regulating the Cardiomyocyte Cell Cycle. Mol Cell Biol. 2012 Dec; 32(24):5089-102.
  5. Takitoh T, Kumamoto K, Wang CC, Sato M, Toba S, Wynshaw-Boris A, Hirotsune S. Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization. J Neurosci. 2012 Aug 8; 32(32):11050-66.
  6. Sinha T, Wang B, Evans S, Wynshaw-Boris A, Wang J. Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis. Dev Biol. 2012 Oct 1; 370(1):135-44.
  7. Wang J, Sinha T, Wynshaw-Boris A. Wnt signaling in mammalian development: lessons from mouse genetics. Cold Spring Harb Perspect Biol. 2012 May; 4(5).
  8. Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork NJ, Courchesne E. Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet. 2012; 8(3):e1002592.
  9. Kawabata I, Kashiwagi Y, Obashi K, Ohkura M, Nakai J, Wynshaw-Boris A, Yanagawa Y, Okabe S. LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites. Nat Commun. 2012; 3:722.
  10. Chow ML, Winn ME, Li HR, April C, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded Samples. Front Genet. 2012; 3:11.
  11. Wynshaw-Boris A. Dishevelled: in vivo roles of a multifunctional gene family during development. Curr Top Dev Biol. 2012; 101:213-35.
  12. Chow ML, Li HR, Winn ME, April C, Barnes CC, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples. BMC Genomics. 2011; 12:449.
  13. Wynshaw-Boris A, Risch N, Motulsky A. Charles Joseph Epstein, M.D., 1933–2011, in memoriam. Am J Hum Genet. 2011 Jun 10; 88(6):684-8.
  14. Pramparo T, Libiger O, Jain S, Li H, Youn YH, Hirotsune S, Schork NJ, Wynshaw-Boris A. Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects. PLoS Genet. 2011 Mar; 7(3):e1001331.
  15. Hippenmeyer S, Youn YH, Moon HM, Miyamichi K, Zong H, Wynshaw-Boris A, Luo L. Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration. Neuron. 2010 Nov 18; 68(4):695-709.
  16. Wynshaw-Boris A, Pramparo T, Youn YH, Hirotsune S. Lissencephaly: mechanistic insights from animal models and potential therapeutic strategies. Semin Cell Dev Biol. 2010 Oct; 21(8):823-30.
  17. Yamada M, Hirotsune S, Wynshaw-Boris A. A novel strategy for therapeutic intervention for the genetic disease: preventing proteolytic cleavage using small chemical compound. Int J Biochem Cell Biol. 2010 Sep; 42(9):1401-7.
  18. Yamada M, Hirotsune S, Wynshaw-Boris A. The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis. Cell Adh Migr. 2010 Apr-Jun; 4(2):180-4.
  19. Pramparo T, Youn YH, Yingling J, Hirotsune S, Wynshaw-Boris A. Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reduction. J Neurosci. 2010 Feb 24; 30(8):3002-12.
  20. Hashimoto M, Shinohara K, Wang J, Ikeuchi S, Yoshiba S, Meno C, Nonaka S, Takada S, Hatta K, Wynshaw-Boris A, Hamada H. Planar polarization of node cells determines the rotational axis of node cilia. Nat Cell Biol. 2010 Feb; 12(2):170-6.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.

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