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Chronic Sildenafil for Severe Diaphragmatic Hernia

STATUS: Terminated

University of California, San Francisco
Children's Hospital Los Angeles
Ann & Robert H Lurie Children's Hospital of Chicago


The purpose of this study is to test if sildenafil is effective in the treatment of infants with severe congenital diaphragmatic hernia (determined by the presence of prolonged pulmonary hypertension or prolonged oxygen supplementation on mechanical ventilation), as measured by the estimated pulmonary artery systolic pressure following treatment.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Official Title

Chronic Sildenafil for Severe Diaphragmatic Hernia


Ages Eligible for Study: N/A - 42 Days

Genders Eligible for Study


Location and Contact Information

More Information

Study ID Numbers: K23HL79922-01

Date study started: February 2006

For additional information, visit processed this data on November 25, 2015

This directory includes clinical trials that involve researchers at UCSF Medical Center. The information was obtained from, a database of the U.S. National Institutes of Health.