Bone Marrow Transplant

Reduced Intensity Conditioning Regimens

Reduced intensity conditioning refers to a conditioning regimen that uses less chemotherapy and radiation than the standard myeloablative conditioning regimen. Myeloablation is the result of an intensive conditioning regimen in which the bone marrow cells are destroyed. The goal of using a reduced intensity conditioning regimen is to decrease the transplant-related complications, toxicity and mortality. However, since myeloablation may not be achieved with this approach, the risk of rejecting the transplant may be higher compared to a full-intensity (myeloablative) conditioning regimen.

We offer two different reduced-intensity conditioning regimens. One uses busulfan, Fludarabine and anti-thymocyte globulin (ATG), which is an antibody made in rabbits and used to increase the likelihood of engraftment in bone marrow transplant recipients and to treat graft-versus-host disease (GvHD). This regimen is offered to patients with bone marrow failure syndromes, myelodysplastic syndrome, acute and chronic myeloid leukemias or metabolic disorders. The advantage of this conditioning is that it reduces the incidence of disease and eliminates mortality during conditioning regimen. The disadvantage is that the rate of transplant rejection may be higher than with a myeloablative regimen.

The other reduced intensity conditioning regimen uses Fludarabine, Melphalan, rabbit ATG and additional donor lymphocyte infusions post transplant. This regimen is offered to patients with acute leukemias who sustained organ damage from previous therapies. The advantage of this conditioning regimen is that it is safer than the myeloablative conditioning. We are currently investigating if donor lymphocyte infusions can reduce the risk of relapse after reduced intensity conditioning.

Eligibility

These regimes are used for patients with:

• Immune deficiencies or bone marrow failure defects, such as congenital neutropenia, thrombocytopenia and aplastic anemia
• Pre-leukemia syndromes, such as myelodysplastic syndrome and monosomy 7
• Acute myeloid leukemia (AML) in first remission or chronic myeloid leukemia (CML) in the chronic phase
• Metabolic disorders, such as Hurler's disease, metachromatic leukodystrophy and adrenal leukodystrophy
• Acute leukemia and dysfunction of the lung, heart or kidney or previous life-threatening infections or treatment complications

Currently, the non-myeloablative protocol is open to children who have the following:

• A related or unrelated donor including umbilical cord blood
• High-risk for a transplant-related toxic complication
• Leukemia or a non-malignant bone marrow disorder
• High risk leukemia and the inability to withstand a standard transplant using high-dose chemotherapy

Eventually, we hope to be able to offer this potentially safer approach to all bone marrow transplant patients.

• Specific Treatment Options
• Bone Marrow Transplant Process
• Graft-Versus-Host Disease
• More BMT Patient Education
• Bone Marrow Transplant Program Overview

Reviewed by health care specialists at UCSF Children's Hospital.
Last updated May 8, 2007

This information is for educational purposes only and is not intended to replace the advice of your doctor or health care provider. We encourage you to discuss with your doctor any questions or concerns you may have.