Based on your family history, genetic testing results and other cancer risk factors, your counselors and doctors will provide you with an individualized risk management program that includes recommendations for cancer screening, prevention and treatment options.
If you tested positive for Lynch syndrome, but do not have a cancer diagnosis, or your doctor suspects that you have Lynch syndrome, the following cancer screening plan may be recommended.
Colonoscopy every one to two years, starting at the age of 20 to 25 years (age 30 years in families with a certain mutation known as MSH6) or 10 years younger than the youngest age at diagnosis in the family, whichever comes first.
While there is no established screening for endometrial cancer at this time, given the high risk of developing the disease in women with Lynch syndrome, the following may be recommended:
Surgery may be recommended to patients with colorectal cancer who test positive for Lynch syndrome in order to prevent additional cancer. For instance, if you have colorectal cancer and test positive for Lynch syndrome, it may be recommended to remove the majority of your colon at the time of your surgery for colon cancer, which would reduce your risk of developing another primary colorectal cancer tumor from 40 percent to 1 percent. Likewise, female patients with colorectal cancer may also want to consider having their uterus and ovaries removed to prevent the occurrence of endometrial and ovarian cancer associated with Lynch syndrome.
Your counselors and doctors can help you decide which treatment option is the best for you.
Reviewed by health care specialists at UCSF Medical Center.
Cancer Genetics and Prevention Program at Mount Zion
1600 Divisadero St., Second Floor
San Francisco, CA 94143-1714
Phone: (415) 885-7779
Fax: (415) 885-3787