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Daniel Lowenstein, M.D.

Epilepsy specialist and director of the Epilepsy Center

Dr. Daniel H. Lowenstein, director of the Epilepsy Center, is focused on expanding epilepsy care and services for UCSF Medical Center patients. An internationally known epileptologist, he was recently appointed director of the Epilepsy Center after serving as Dean of Medical Education at Harvard Medical School, of which he is a graduate. He also is currently president-elect of the American Epilepsy Society. Lowenstein spent many years at UCSF as professor of neurology and director of the Epilepsy Research Laboratory in the School of Medicine. A prolific writer and scholar, he has received virtually every teaching award given by UCSF's School of Medicine. His interests include the molecular and cellular changes in neural networks following seizure activity and injury, the genetic basis of epilepsy, and therapy for abnormally prolonged seizures known as status epilepticus.


Epilepsy Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2437
Fax: (415) 353-2837

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

More about Daniel Lowenstein


Harvard University 1983


UCSF, Neurology 1987

Selected Research and Publications

  1. Hegde M, Lowenstein DH. The search for circulating epilepsy biomarkers. Biomark Med. 2014 Mar; 8(3):413-27.
  2. Lowenstein DH, Walker M, Waterhouse E. Status epilepticus in the setting of acute encephalitis. Epilepsy Curr. 2014 Jan; 14(1 Suppl):43-9.
  3. Hauser SL, Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg JR. Quo vadis? - peering into the future. Ann Neurol. 2013 Dec; 74(6):A5-7.
  4. Aggarwal AK, Thompson M, Falik R, Shaw A, O'Sullivan P, Lowenstein DH. Mental illness among us: a new curriculum to reduce mental illness stigma among medical students. Acad Psychiatry. 2013 Nov 1; 37(6):385-91.
  5. Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J, Stewart A, Hauser SL. Have the Annals editors added value? Ann Neurol. 2013 Nov; 74(5):A7-9.
  6. Bleck T, Cock H, Chamberlain J, Cloyd J, Connor J, Elm J, Fountain N, Jones E, Lowenstein D, Shinnar S, Silbergleit R, Treiman D, Trinka E, Kapur J. The established status epilepticus trial 2013. Epilepsia. 2013 Sep; 54 Suppl 6:89-92.
  7. Silbergleit R, Lowenstein D, Durkalski V, Conwit R. Lessons from the RAMPART study--and which is the best route of administration of benzodiazepines in status epilepticus. Epilepsia. 2013 Sep; 54 Suppl 6:74-7.
  8. De novo mutations in epileptic encephalopathies. Nature. 2013 Sep 12; 501(7466):217-21.
  9. Fox CK, Glass HC, Sidney S, Lowenstein DH, Fullerton HJ. Acute seizures predict epilepsy after childhood stroke. Ann Neurol. 2013 Aug; 74(2):249-56.
  10. Hirose S, Scheffer IE, Marini C, De Jonghe P, Andermann E, Goldman AM, Kauffman M, Tan NC, Lowenstein DH, Sisodiya SM, Ottman R, Berkovic SF. SCN1A testing for epilepsy: application in clinical practice. Epilepsia. 2013 May; 54(5):946-52.
  11. Helbig I, Lowenstein DH. Genetics of the epilepsies: where are we and where are we going? Curr Opin Neurol. 2013 Apr; 26(2):179-85.
  12. Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, Barsan W. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012 Feb 16; 366(7):591-600.
  13. Stewart AF, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg JR, Johnston SC, Hauser SL. Fighting decision fatigue. Ann Neurol. 2012 Jan; 71(1):A5-A15.
  14. Rossetti AO, Lowenstein DH. Management of refractory status epilepticus in adults: still more questions than answers. Lancet Neurol. 2011 Oct; 10(10):922-30.
  15. Silbergleit R, Lowenstein D, Durkalski V, Conwit R. RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. Epilepsia. 2011 Oct; 52 Suppl 8:45-7.
  16. Lowenstein DH. Interview: the National Institute of Neurological Diseases and Stroke/American Epilepsy Society benchmarks and research priorities for epilepsy research. Biomark Med. 2011 Oct; 5(5):531-5.
  17. Mateen FJ, Carone M, Nyce S, Ghosn J, Mutuerandu T, Al-Saedy H, Lowenstein DH, Burnham G. Neurological disorders in Iraqi refugees in Jordan: data from the United Nations Refugee Assistance Information System. J Neurol. 2012 Apr; 259(4):694-701.
  18. Durkalski V, Silbergleit R, Lowenstein D. Challenges in the design and analysis of non-inferiority trials: a case study. Clin Trials. 2011 Oct; 8(5):601-8.
  19. Josephson SA, Lowenstein DH. Medical student learning in the preclinical curriculum: many steps behind a rapidly moving world. Ann Neurol. 2011 Jul; 70(1):A9-A10.
  20. Loring DW, Lowenstein DH, Barbaro NM, Fureman BE, Odenkirchen J, Jacobs MP, Austin JK, Dlugos DJ, French JA, Gaillard WD, Hermann BP, Hesdorffer DC, Roper SN, Van Cott AC, Grinnon S, Stout A. Common data elements in epilepsy research: development and implementation of the NINDS epilepsy CDE project. Epilepsia. 2011 Jun; 52(6):1186-91.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.