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James Smith, M.D., M.S.

Director, UCSF Male Reproductive Health

Dr. James Smith directs the team providing male fertility preservation counseling and treatment, and evaluates and treats men with general fertility problems, low testosterone, erectile dysfunction and Peyronie's disease. He specializes in the use of microsurgical vasovasostomy, vasoepididymostomy, sperm retrieval and varicocelectomy. In addition to serving as director of Male Reproductive Health, Smith is an assistant professor of urology and of obstetrics, gynecology and reproductive sciences at the UCSF School of Medicine.

Smith's primary research focus seeks to improve understanding of clinical, translational and basic mechanisms of male reproductive biology. Smith is an active member of the American Urological Association, the American Society for Reproductive Medicine, the Society of Reproductive Surgeons, the Society for Male Reproduction and Urology, and the Sexual Medicine Society of North America.

Smith received his master's degree in health and medical science, and his medical degree, from the University of California's Joint Medical Program (UC Berkeley and UCSF). He did his general surgery and urology training at the University of Utah in Salt Lake City, returning to UCSF to complete a fellowship in andrology.


Center for Reproductive Health at Mission Bay
499 Illinois St., Sixth Floor
San Francisco, CA 94158
Phone: (415) 353-7475
Fax: (415) 353-7744

Hours: Monday to Friday
8 a.m. – 4:45 p.m.
Saturday and Sunday apts. available for patients undergoing treatment

Center for Reproductive Health at Mount Zion
2356 Sutter St., Seventh Floor
San Francisco, CA 94115
Phone: (415) 353-7475
Fax: (415) 353-7744

Hours: Monday to Friday
8 a.m. – 4:45 p.m.
Saturday and Sunday apts. available for patients undergoing treatment

Fertility Preservation Center
2356 Sutter St., Seventh Floor
San Francisco, CA 94115
Phone: (415) 353-9115
Fax: (415) 353-3064

Hours: Monday to Friday
8 a.m. – 5 p.m.

Male Reproductive Health Center
2356 Sutter St., Third Floor
San Francisco, CA 94115
Phone: (415) 353-3076
Fax: (415) 885-3663

Hours: Monday to Friday
8 a.m. – 5 p.m.

Urology Practice
400 Parnassus Ave., Sixth Floor, Suite A610
San Francisco, CA 94143
Phone: (415) 353-2200
Fax: (415) 353-2641

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

More about James Smith


UCSF School of Medicine 2002


University of Utah, Surgery and Urology 2007


UCSF Medical Center, Male Reproductive Health 2009

Selected Research and Publications

  1. Qiu ZJ, Lu YX, Li CQ, Dong Y, Smith JF, Wang YZ. Origin and evolution of Petrocosmea (Gesneriaceae) inferred from both DNA sequence and novel findings in morphology with a test of morphology-based hypotheses. BMC Plant Biol. 2015; 15:167.
  2. Schulte LJ, Clark JL, Novak SJ, Jeffries SK, Smith JF. Speciation within Columnea section Angustiflora (Gesneriaceae): Islands, pollinators and climate. Mol Phylogenet Evol. 2015 Mar; 84:125-44.
  3. Montgomery JI, Smith JF, Tomaras AP, Zaniewski R, McPherson CJ, McAllister LA, Hartman-Neumann S, Arcari JT, Lescoe M, Gutierrez J, Yuan Y, Limberakis C, Miller AA. Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors. J Antibiot (Tokyo). 2015 Jun; 68(6):361-7.
  4. Yango P, Altman E, Smith JF, Klatsky PC, Tran ND. Optimizing cryopreservation of human spermatogonial stem cells: comparing the effectiveness of testicular tissue and single cell suspension cryopreservation. Fertil Steril. 2014 Nov; 102(5):1491-1498.e1.
  5. Smith JF, Yango P, Altman E, Choudhry S, Poelzl A, Zamah AM, Rosen M, Klatsky PC, Tran ND. Testicular niche required for human spermatogonial stem cell expansion. Stem Cells Transl Med. 2014 Sep; 3(9):1043-54.
  6. Altman E, Yango P, Moustafa R, Smith JF, Klatsky PC, Tran ND. Characterization of human spermatogonial stem cell markers in fetal, pediatric, and adult testicular tissues. Reproduction. 2014 Oct; 148(4):417-27.
  7. Wang Y, Tretter ED, Johnson EM, Kandel P, Lichtwardt RW, Novak SJ, Smith JF, White MM. Using a five-gene phylogeny to test morphology-based hypotheses of Smittium and allies, endosymbiotic gut fungi (Harpellales) associated with arthropods. Mol Phylogenet Evol. 2014 Oct; 79:23-41.
  8. Odisho AY, Nangia AK, Katz PP, Smith JF. Temporal and geospatial trends in male factor infertility with assisted reproductive technology in the United States from 1999-2010. Fertil Steril. 2014 Aug; 102(2):469-75.
  9. Tretter ED, Johnson EM, Benny GL, Lichtwardt RW, Wang Y, Kandel P, Novak SJ, Smith JF, White MM. An eight-gene molecular phylogeny of the Kickxellomycotina, including the first phylogenetic placement of Asellariales. Mycologia. 2014 Sep-Oct; 106(5):912-35.
  10. Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC. Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol. 2014 Jul; 88(13):7221-34.
  11. Carter KA, Smith JF, White MM, Serpe MD. Assessing the diversity of arbuscular mycorrhizal fungi in semiarid shrublands dominated by Artemisia tridentata ssp. wyomingensis. Mycorrhiza. 2014 May; 24(4):301-14.
  12. Mannowetz N, Naidoo NM, Choo SA, Smith JF, Lishko PV. Slo1 is the principal potassium channel of human spermatozoa. Elife. 2013; 2:e01009.
  13. Gaskin JF, Schwarzländer M, Kinter CL, Smith JF, Novak SJ. Propagule pressure, genetic structure, and geographic origins of Chondrilla juncea (Asteraceae): an apomictic invader on three continents. Am J Bot. 2013 Sep; 100(9):1871-82.
  14. Wu AK, Odisho AY, Washington SL, Katz PP, Smith JF. Out-of-pocket fertility patient expense: data from a multicenter prospective infertility cohort. J Urol. 2014 Feb; 191(2):427-32.
  15. Smith JF, Syritsyna O, Fellous M, Serres C, Mannowetz N, Kirichok Y, Lishko PV. Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6823-8.
  16. Mitton-Fry MJ, Brickner SJ, Hamel JC, Brennan L, Casavant JM, Chen M, Chen T, Ding X, Driscoll J, Hardink J, Hoang T, Hua E, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Plotkin M, Reilly U, Robinson S, Schafer J, Shepard RM, Smith JF, Stone GG, Subramanyam C, Yoon K, Yuan W, Zaniewski RP, Zook C. Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett. 2013 May 15; 23(10):2955-61.
  17. Wu AK, Elliott P, Katz PP, Smith JF. Time costs of fertility care: the hidden hardship of building a family. Fertil Steril. 2013 Jun; 99(7):2025-30.
  18. Clay DL, Novak SJ, Serpe MD, Tank DC, Smith JF. Homoploid hybrid speciation in a rare endemic Castilleja from Idaho (Castilleja christii, Orobanchaceae). Am J Bot. 2012 Dec; 99(12):1976-90.
  19. Letourneau JM, Smith JF, Ebbel EE, Craig A, Katz PP, Cedars MI, Rosen MP. Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer. Cancer. 2012 Sep 15; 118(18):4579-88.
  20. Smith JF, Breyer BN, Shindel AW. Predictors of sexual bother in a population of male North American medical students. J Sex Med. 2011 Dec; 8(12):3363-9.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.