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John P. Kane, Ph.D., M.D.

Director, Adult Lipid Clinic

Dr. John Kane, Ph.D., is the director of the Adult Lipid Clinic. He earned his medical degree at the University of Oregon School of Medicine. He completed an internship and residency in internal medicine at Stanford and UCSF; and a fellowship in endocrinology at UCSF. His research in lipoprotein metabolism, the management of disorders of lipoproteins, and the genetic bases of heart disease and stroke is known worldwide through his publications in refereed journals and book chapters. Kane is professor of medicine and professor of biochemistry and biophysics, and is an associate director of the Cardiovascular Research Institute at UCSF. He is a fellow of the Established Investigator of the American Heart Association. He is a recent recipient of an Outstanding Achievement Award in the Genetics of Lipoprotein Metabolism and Atherosclerosis from the International Atherosclerosis Society. He is a diplomate of the American Board of Clinical Lipidology.

Clinics

Lipid Practice
400 Parnassus Ave., Suite A-550
San Francisco, CA 94143
Phone: (415) 353–2350
Fax: (415) 353–2337

Hours: Monday to Friday, 8:30 a.m. – 5 p.m.

More about John P. Kane

Additional Languages

French
Russian
Spanish

Education

University of Oregon 1957

Residencies

Stanford University Hospitals
UCSF

Fellowships

UCSF, Endocrinology

Selected Research and Publications

  1. Malloy MJ, Kane JP. Hyperlipidemia and cardiovascular disease. Curr Opin Lipidol. 2012 Dec; 23(6):591-2.
  2. Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 2012 Nov 11; 44(12):1341-8.
  3. Kane JP, Malloy MJ. Prebeta-1 HDL and coronary heart disease. Curr Opin Lipidol. 2012 Aug; 23(4):367-71.
  4. Charles MA, Kane JP. New molecular insights into CETP structure and function: a review. J Lipid Res. 2012 Aug; 53(8):1451-8.
  5. Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM. Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet. 2012 May 4; 90(5):796-808.
  6. Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM. Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2012 Jun; 9(6):961-7.
  7. Luke MM, Berger K, Rowland CM, Catanese JJ, Tong CH, Ross DA, Garcia V, Kuhlenbaeumer G, Ringelstein EB, Pullinger CR, Malloy MJ, Deedwania P, Ellis SG, Kane JP, Devlin JJ, Lalouschek W, Mannhalter C. Polymorphisms and noncardioembolic stroke in three case-control studies. Cerebrovasc Dis. 2012; 33(1):80-5.
  8. Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, Fairbrother WG, Neve RL, Kane JP, Malloy MJ, Pullinger CR, Gu HF, Tsatsanis C, Hamilton SP, Gold SJ, Zachariou V, Kovoor A. Association between regulator of G protein signaling 9-2 and body weight. PLoS One. 2011; 6(11):e27984.
  9. Guey LT, Pullinger CR, Ishida BY, O'Connor PM, Zellner C, Francone OL, Laramie JM, Naya-Vigne JM, Siradze KA, Deedwania P, Redberg RF, Frost PH, Seymour AB, Kane JP, Malloy MJ. Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease. Am J Cardiol. 2011 Aug 1; 108(3):360-6.
  10. DuBois SG, Goldsby R, Segal M, Woo J, Copren K, Kane JP, Pullinger CR, Matthay KK, Witte J, Lessnick SL, Robison LL, Bhatia S, Strong LC. Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer. 2012 Jul 15; 59(1):52-6.
  11. Ruaño G, Windemuth A, Wu AH, Kane JP, Malloy MJ, Pullinger CR, Kocherla M, Bogaard K, Gordon BR, Holford TR, Gupta A, Seip RL, Thompson PD. Mechanisms of statin-induced myalgia assessed by physiogenomic associations. Atherosclerosis. 2011 Oct; 218(2):451-6.
  12. Francone OL, Ishida BY, de la Llera-Moya M, Royer L, Happe C, Zhu J, Chalkey RJ, Schaefer P, Cox C, Burlingame A, Kane JP, Rothblat GH. Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels. J Lipid Res. 2011 Nov; 52(11):1974-83.
  13. Chiefari E, Tanyolaç S, Paonessa F, Pullinger CR, Capula C, Iiritano S, Mazza T, Forlin M, Fusco A, Durlach V, Durlach A, Malloy MJ, Kane JP, Heiner SW, Filocamo M, Foti DP, Goldfine ID, Brunetti A. Functional variants of the HMGA1 gene and type 2 diabetes mellitus. JAMA. 2011 Mar 2; 305(9):903-12.
  14. Durlach V, Durlach A, Movesayan I, Socquard E, Zellner C, Clavel C, Nazeyrollas P, Malloy MJ, Pullinger CR, Kane JP, Ducasse A, Aouizerat BE. Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients. Diabetes Metab. 2011 Feb; 37(1):64-71.
  15. Zhang L, Song J, Cavigiolio G, Ishida BY, Zhang S, Kane JP, Weisgraber KH, Oda MN, Rye KA, Pownall HJ, Ren G. Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy. J Lipid Res. 2011 Jan; 52(1):175-84.
  16. Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Pharmacogenomics. 2010 Jul; 11(7):959-71.
  17. Pullinger CR, Aouizerat BE, Gay C, Coggins T, Movsesyan I, Davis H, Kane JP, Portillo C, Lee KA. Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults. Metab Syndr Relat Disord. 2010 Jun; 8(3):279-86.
  18. Shiffman D, Louie JZ, Rowland CM, Malloy MJ, Kane JP, Devlin JJ. Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus. Atherosclerosis. 2010 Sep; 212(1):193-6.
  19. Pan J, Shilian P, Ishida B, Wu X, Kane JP, Malloy MJ, Charles MA. Effect of niacin on preß-1 high-density lipoprotein levels in diabetes. Metabolism. 2011 Feb; 60(2):292-7.
  20. Fujimoto VY, Kane JP, Ishida BY, Bloom MS, Browne RW. High-density lipoprotein metabolism and the human embryo. Hum Reprod Update. 2010 Jan-Feb; 16(1):20-38.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.

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