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Karen Smith-McCune, M.D.

Obstetrician and gynecologist

Dr. Karen K. Smith-McCune, an obstetrician and gynecologist, is the director of the Dysplasia Clinic at UCSF. She has a special interest in abnormal pap smears, cervical precancer, cervical cancer screening, human papillomavirus virus and vulvar disease. One of her research goals is to identify drugs that merit clinical testing for treatment of cervical dysplasia or cancer as well as to improve tests used by clinicians to quickly and accurately distinguish low-grade cervical dysplasias from high-grade ones.

In addition to treating patients, Smith-McCune is the John Kerner Endowed Chair of Gynecologic Oncology and an associate professor in the Department of Obstetrics, Gynecology, and Reproductive Sciences. Smith-McCune completed her medical degree at Stanford University and her residency and fellowship at UCSF.


Gynecologic Dysplasia Clinic
1600 Divisadero, Fourth Floor
San Francisco, CA 94115
Phone: (415) 514-0800
Fax: (415) 353- 4298

Hours: Monday to Friday
8 a.m. – 5 p.m.

More about Karen Smith-McCune


Stanford University School of Medicine 1986

Selected Research and Publications

  1. Smith-McCune K. Quadrivalent HPV vaccine administered to women who became pregnant during trials did not appear to adversely affect pregnancy outcome; however, use during pregnancy is not recommended. Evid Based Med. 2010 Jun; 15(3):80-1.
  2. Smith-McCune KK, Shiboski S, Chirenje MZ, Magure T, Tuveson J, Ma Y, Da Costa M, Moscicki AB, Palefsky JM, Makunike-Mutasa R, Chipato T, van der Straten A, Sawaya GF. Type-specific cervico-vaginal human papillomavirus infection increases risk of HIV acquisition independent of other sexually transmitted infections. PLoS One. 2010; 5(4):e10094.
  3. Smith-McCune KK, Tuveson JL, Rubin MM, Da Costa MM, Darragh TM, Shiboski SC, Van Der Pol B, Moscicki AB, Palefsky JM, Sawaya GF. Effect of Replens gel used with a diaphragm on tests for human papillomavirus and other lower genital tract infections. J Low Genit Tract Dis. 2006 Oct; 10(4):213-8.
  4. Ancheta E, Perry J, Bernard-Pearl L, Paul S, Darragh T, Smith-McCune K. Participants at the ASCCP 2000 Biennial Meeting adhere to published guidelines in their management of atypical squamous cells and atypical glandular cells on pap test. J Low Genit Tract Dis. 2003 Oct; 7(4):279-84.
  5. Smith-McCune K, Mancuso V, Contant T, Jackson R. Management of women with atypical Papanicolaou tests of undetermined significance by board-certified gynecologists: discrepancies with published guidelines. Am J Obstet Gynecol. 2001 Sep; 185(3):551-6.
  6. Smith-McCune K, Kalman D, Robbins C, Shivakumar S, Yuschenkoff L, Bishop JM. Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130. Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12):6999-7004.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.