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Linda Giudice, Ph.D., M.D.

Obstetrician, gynecologist and reproductive endocrinologist

Dr. Linda Giudice is an obstetrician, gynecologist and reproductive endocrinologist at UCSF Medical Center. She specializes in endometriosis, implantation and ovulatory disorders, infertility and assisted reproduction. She also is professor and chair of Obstetrics, Gynecology and Reproductive Sciences at the UCSF School of Medicine. In her research, she focuses on endometrial biology and placental-uterine interactions as well as environmental impacts on reproductive health.

Giudice earned a Ph.D. in biochemistry at UCLA and completed a postdoctoral fellowship at Rockefeller University, working under Nobel Laureate Gunter Blobel. She earned a medical degree at Stanford University and completed a residency in obstetrics and gynecology at Stanford and Washington University in St. Louis as well as a fellowship in reproductive endocrinology and infertility at Stanford. She served as director of the reproductive endocrinology and infertility division at Stanford before joining UCSF in 2005. Giudice is president-elect of the American Society for Reproductive Medicine and a member of the Institute of Medicine of the National Academy of Sciences.

Clinics

Center for Reproductive Health at Mission Bay
499 Illinois St., Sixth Floor
San Francisco, CA 94158
Phone: (415) 353-7475
Fax: (415) 353-7744

Hours: Monday to Friday
8 a.m. – 4:45 p.m.
Saturday and Sunday apts. available for patients undergoing treatment

Center for Reproductive Health at Mount Zion
2356 Sutter St., Seventh Floor
San Francisco, CA 94115
Phone: (415) 353-7475
Fax: (415) 353-7744

Hours: Monday to Friday
8 a.m. – 4:45 p.m.
Saturday and Sunday apts. available for patients undergoing treatment

Conditions & Treatments

More about Linda Giudice

Education

Stanford School of Medicine 1982

Residencies

Stanford University Medical Center, Obstetrics & Gynecology 1984
Barnes-Jewish Hospital, Obstetrics & Gynecology 1986

Fellowships

Stanford University Medical Center, Reproductive Endocrinology and Infertility

Selected Research and Publications

  1. Smith-McCune K, Chen JC, Greenblatt RM, Shanmugasundaram U, Shacklett BL, Hilton JF, Johnson B, Irwin JC, Giudice LC. Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study. PLoS One. 2015; 10(7):e0129769.
  2. Fassbender A, Burney RO, O DF, D'Hooghe T, Giudice L. Update on Biomarkers for the Detection of Endometriosis. Biomed Res Int. 2015; 2015:130854.
  3. Vercellini P, Giudice LC, Evers JL, Abrao MS. Reducing low-value care in endometriosis between limited evidence and unresolved issues: a proposal. Hum Reprod. 2015 Sep; 30(9):1996-2004.
  4. Heard ME, Velarde MC, Giudice LC, Simmen FA, Simmen RC. Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis. Biol Reprod. 2015 Jun; 92(6):140.
  5. Piltonen TT, Chen JC, Khatun M, Kangasniemi M, Liakka A, Spitzer T, Tran N, Huddleston H, Irwin JC, Giudice LC. Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro. Hum Reprod. 2015 May; 30(5):1203-15.
  6. Goldfien GA, Barragan F, Chen J, Takeda M, Irwin JC, Perry J, Greenblatt RM, Smith-McCune KK, Giudice LC. Progestin-Containing Contraceptives Alter Expression of Host Defense-Related Genes of the Endometrium and Cervix. Reprod Sci. 2015 Jul; 22(7):814-28.
  7. Williams KE, Miroshnychenko O, Johansen EB, Niles RK, Sundaram R, Kannan K, Albertolle M, Zhou Y, Prasad N, Drake PM, Giudice LC, Hall SC, Witkowska HE, Buck Louis GM, Fisher SJ. Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals. J Proteomics. 2015 Jan 15; 113:194-205.
  8. Tamaresis JS, Irwin JC, Goldfien GA, Rabban JT, Burney RO, Nezhat C, DePaolo LV, Giudice LC. Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology. 2014 Dec; 155(12):4986-99.
  9. Vitonis AF, Vincent K, Rahmioglu N, Fassbender A, Buck Louis GM, Hummelshoj L, Giudice LC, Stratton P, Adamson GD, Becker CM, Zondervan KT, Missmer SA. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: II. Clinical and covariate phenotype data collection in endometriosis research. Fertil Steril. 2014 Nov; 102(5):1223-32.
  10. Rahmioglu N, Fassbender A, Vitonis AF, Tworoger SS, Hummelshoj L, D'Hooghe TM, Adamson GD, Giudice LC, Becker CM, Zondervan KT, Missmer SA. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research. Fertil Steril. 2014 Nov; 102(5):1233-43.
  11. Fassbender A, Rahmioglu N, Vitonis AF, Viganò P, Giudice LC, D'Hooghe TM, Hummelshoj L, Adamson GD, Becker CM, Missmer SA, Zondervan KT. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research. Fertil Steril. 2014 Nov; 102(5):1244-53.
  12. Houshdaran S, Zelenko Z, Irwin JC, Giudice LC. Human endometrial DNA methylome is cycle-dependent and is associated with gene expression regulation. Mol Endocrinol. 2014 Jul; 28(7):1118-35.
  13. Alvarez P, Giudice LC, Levine JD. Impact of surgical excision of lesions on pain in a rat model of endometriosis. Eur J Pain. 2015 Jan; 19(1):103-10.
  14. Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR. Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod. 2014 Jun; 29(6):1255-70.
  15. Shanmugasundaram U, Critchfield JW, Pannell J, Perry J, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett BL. Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women. Am J Reprod Immunol. 2014 Feb; 71(2):95-108.
  16. Alvarez P, Bogen O, Chen X, Giudice LC, Levine JD. Ectopic endometrium-derived leptin produces estrogen-dependent chronic pain in a rat model of endometriosis. Neuroscience. 2014 Jan 31; 258:111-20.
  17. Altmäe S, Esteban FJ, Stavreus-Evers A, Simón C, Giudice L, Lessey BA, Horcajadas JA, Macklon NS, D'Hooghe T, Campoy C, Fauser BC, Salamonsen LA, Salumets A. Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium. Hum Reprod Update. 2014 Jan-Feb; 20(1):12-28.
  18. Bergman Å, Andersson AM, Becher G, van den Berg M, Blumberg B, Bjerregaard P, Bornehag CG, Bornman R, Brandt I, Brian JV, Casey SC, Fowler PA, Frouin H, Giudice LC, Iguchi T, Hass U, Jobling S, Juul A, Kidd KA, Kortenkamp A, Lind M, Martin OV, Muir D, Ochieng R, Olea N, Norrgren L, Ropstad E, Ross PS, Rudén C, Scheringer M, Skakkebaek NE, Söder O, Sonnenschein C, Soto A, Swan S, Toppari J, Tyler CR, Vandenberg LN, Vinggaard AM, Wiberg K, Zoeller RT. Science and policy on endocrine disrupters must not be mixed: a reply to a "common sense" intervention by toxicology journal editors. Environ Health. 2013; 12:69.
  19. Hess AP, Talbi S, Hamilton AE, Baston-Buest DM, Nyegaard M, Irwin JC, Barragan F, Kruessel JS, Germeyer A, Giudice LC. The human oviduct transcriptome reveals an anti-inflammatory, anti-angiogenic, secretory and matrix-stable environment during embryo transit. Reprod Biomed Online. 2013 Oct; 27(4):423-35.
  20. Chen JC, Erikson DW, Piltonen TT, Meyer MR, Barragan F, McIntire RH, Tamaresis JS, Vo KC, Giudice LC, Irwin JC. Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production. Fertil Steril. 2013 Oct; 100(4):1132-43.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.