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Home > Doctors > Manish Kumar Aghi

Manish Kumar Aghi, Ph.D., M.D.

Neurosurgeon

Dr. Manish Aghi is a neurosurgeon specializing in adult brain tumors at UCSF Medical Center. He cares for patients with a wide range of conditions, including astrocytomas, oligodendrogliomas, anaplastic astrocytomas, glioblastomas, meningiomas, and pituitary adenomas. As principal investigator at the UCSF Brain Tumor Research Center, his research interests include glioblastoma angiogenesis, mechanisms of glioblastoma resistance to anti-angiogenic therapy, and experimental glioblastoma therapies like oncolytic viruses.

Aghi earned a medical degree and a doctoral degree in neurosciences from Harvard Medical School and completed a neurosurgery residency at Massachusetts General Hospital. He is a member of the Society for Neuro-oncology, American Association of Neurological Surgeons, Congress of Neurologic Surgeons and Pituitary Network Association. Among his honors are the Ronald L. Bittner Award; Preuss Award and Mahaley Award from the American Association of Neurological Surgeons; and the Synthes Skull Base Award and the Integra Foundation Award from the Congress of Neurological Surgeons. He is an assistant professor in residence in neurological surgery at UCSF.

Conditions & Treatments

Clinics

California Center for Pituitary Disorders
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (866) 559-5543

Fax: (415) 353-2939

Hours: Monday to Friday
8 a.m. – 5 p.m.

Neuro-Oncology Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2966
Fax: (415) 353-2167

Hours: Monday to Friday
8 a.m. – 5 p.m.

Neurosurgery Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-7500
Fax: (415) 353-2939

Hours: Monday to Friday
8 a.m. – 4:30 p.m.

More about Manish Kumar Aghi

Education

Harvard Medical School 2000

Residencies

Massachusetts General Hospital, Neurosurgery 2007

Selected Research and Publications

  1. Hu YL, Delay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, Aghi MK. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 2012 Apr 1; 72(7):1773-83.
  2. Jahangiri A, Aghi MK. Pseudoprogression and treatment effect. Neurosurg Clin N Am. 2012 Apr; 23(2):277-87.
  3. Clark AJ, Lamborn KR, Butowski NA, Chang SM, Prados MD, Clarke JL, McDermott MW, Parsa AT, Berger MS, Aghi MK. Neurosurgical management and prognosis of patients with glioblastoma that progresses during bevacizumab treatment. Neurosurgery. 2012 Feb; 70(2):361-70.
  4. Agarwalla PK, Aghi MK. Oncolytic herpes simplex virus engineering and preparation. Methods Mol Biol. 2012; 797:1-19.
  5. Vogelbaum MA, Jost S, Aghi MK, Heimberger AB, Sampson JH, Wen PY, Macdonald DR, Van den Bent MJ, Chang SM. Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group. Neurosurgery. 2012 Jan; 70(1):234-43; discussion 243-4.
  6. Potts MB, Jahangiri A, Lamborn KR, Blevins LS, Kunwar S, Aghi MK. Suprasellar Rathke cleft cysts: clinical presentation and treatment outcomes. Neurosurgery. 2011 Nov; 69(5):1058-68; discussion 1068-7.
  7. Jahangiri A, Aghi MK. Biomarkers predicting tumor response and evasion to anti-angiogenic therapy. Biochim Biophys Acta. 2012 Jan; 1825(1):86-100.
  8. Sughrue ME, Chang EF, Gabriel RA, Aghi MK, Blevins LS. Excess mortality for patients with residual disease following resection of pituitary adenomas. Pituitary. 2011 Sep; 14(3):276-83.
  9. Kaur G, Bloch O, Jian BJ, Kaur R, Sughrue ME, Aghi MK, McDermott MW, Berger MS, Chang SM, Parsa AT. A critical evaluation of cystic features in primary glioblastoma as a prognostic factor for survival. J Neurosurg. 2011 Oct; 115(4):754-9.
  10. Aghi MK, Walcott BP, Nahed BV, Cvetanovich GL, Kahle KT, Redjal N, Coumans JV. Determinants of initial bone graft volume loss in posterolateral lumbar fusion. J Clin Neurosci. 2011 Sep; 18(9):1193-6.
  11. Jahangiri A, Lamborn KR, Blevins L, Kunwar S, Aghi MK. Factors associated with delay to pituitary adenoma diagnosis in patients with visual loss. J Neurosurg. 2012 Feb; 116(2):283-9.
  12. Jahangiri A, Molinaro AM, Tarapore PE, Blevins L, Auguste KI, Gupta N, Kunwar S, Aghi MK. Rathke cleft cysts in pediatric patients: presentation, surgical management, and postoperative outcomes. Neurosurg Focus. 2011 Jul; 31(1):E3.
  13. Oh MC, Aghi MK. Dopamine agonist-resistant prolactinomas. J Neurosurg. 2011 May; 114(5):1369-79.
  14. Clark AJ, Butowski NA, Chang SM, Prados MD, Clarke J, Polley MY, Sughrue ME, McDermott MW, Parsa AT, Berger MS, Aghi MK. Impact of bevacizumab chemotherapy on craniotomy wound healing. J Neurosurg. 2011 Jun; 114(6):1609-16.
  15. Rowland NC, Aghi MK. Radiation treatment strategies for acromegaly. Neurosurg Focus. 2010 Oct; 29(4):E12.
  16. Zlotnick D, Kalkanis SN, Quinones-Hinojosa A, Chung K, Linskey ME, Jensen RL, DeMonte F, Barker FG, Racine CA, Berger MS, Black PM, Cusimano M, Sekhar LN, Parsa A, Aghi M, McDermott MW. FACT-MNG: tumor site specific web-based outcome instrument for meningioma patients. J Neurooncol. 2010 Sep; 99(3):423-31.
  17. Tate MC, Jahangiri A, Blevins L, Kunwar S, Aghi MK. Infected Rathke cleft cysts: distinguishing factors and factors predicting recurrence. Neurosurgery. 2010 Sep; 67(3):762-9; discussion 769.
  18. Sughrue ME, Aghi MK. Reconstruction of dural defects of the endonasal skull base. Neurosurg Clin N Am. 2010 Oct; 21(4):637-41, vi.
  19. Nahed BV, Walcott BP, Ortman AJ, Kahle KT, Aghi M, Peterfreund RA, Coumans JV. Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis. J Clin Neurosci. 2010 Aug; 17(8):1085-8.
  20. Chahal M, Xu Y, Lesniak D, Graham K, Famulski K, Christensen JG, Aghi M, Jacques A, Murray D, Sabri S, Abdulkarim B. MGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib. Neuro Oncol. 2010 Aug; 12(8):822-33.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.

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