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Maria L. Wei, M.D., Ph.D.

Dermatologist

Dr. Maria L. Wei is a dermatologist who specializes in melanoma and disorders of pigmentation (acquired and inherited). She is Director of the UCSF Melanoma Surveillance clinic that sees individuals with melanoma, or those at high risk for developing melanoma such as those with a family history of melanoma, positive genetic testing showing a risk of melanoma, or those with many moles or large congenital moles.

Wei leads a research laboratory that studies melanoma and melanocyte biology and how melanomas become resistant to treatment. The laboratory also studies why there is a gender disparity in melanoma outcomes, men having worse outcomes, and in addition is investigating novel biomarkers for melanoma.

Clinics

Dermatology Clinic
1701 Divisadero St., Third and Fourth Floors
San Francisco, CA 94115
Phone: (415) 353–7800
Fax: (415) 353–7870

Hours: Monday to Friday, 8 a.m. – 5 p.m.

Melanoma Center
1600 Divisadero St.,
San Francisco, CA 94115
Phone: (415) 353-9900
Fax: (415) 885-3802

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

More about Maria L. Wei

Education

Duke University School of Medicine 1992

Residencies

Brigham and Woman's Hospital, Internal Medicine 1993
UCSF Medical Center, Dermatology 1997

Fellowships

UCSF Medical Center, Biochemistry and Biophysics 2002

Selected Research and Publications

  1. Man MQ, Lin TK, Santiago JL, Celli A, Zhong L, Huang ZM, Roelandt T, Hupe M, Sundberg JP, Silva KA, Crumrine D, Martin-Ezquerra G, Trullas C, Sun R, Wakefield JS, Wei ML, Feingold KR, Mauro TM, Elias PM. Basis for enhanced barrier function of pigmented skin. J Invest Dermatol. 2014 Sep; 134(9):2399-407.
  2. Huang ZM, Chinen M, Chang PJ, Xie T, Zhong L, Demetriou S, Patel MP, Scherzer R, Sviderskaya EV, Bennett DC, Millhauser GL, Oh DH, Cleaver JE, Wei ML. Targeting protein-trafficking pathways alters melanoma treatment sensitivity. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):553-8.
  3. Agarwal P, Verzi MP, Nguyen T, Hu J, Ehlers ML, McCulley DJ, Xu SM, Dodou E, Anderson JP, Wei ML, Black BL. The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development. 2011 Jun; 138(12):2555-65.
  4. Xie T, Nguyen T, Hupe M, Wei ML. Multidrug resistance decreases with mutations of melanosomal regulatory genes. Cancer Res. 2009 Feb 1; 69(3):992-9.
  5. Nguyen T, Wei ML. Hermansky-Pudlak HPS1/pale ear gene regulates epidermal and dermal melanocyte development. J Invest Dermatol. 2007 Feb; 127(2):421-8.
  6. Wei ML. Hermansky-Pudlak syndrome: a disease of protein trafficking and organelle function. Pigment Cell Res. 2006 Feb; 19(1):19-42.
  7. Nguyen T, Wei ML. Characterization of melanosomes in murine Hermansky-Pudlak syndrome: mechanisms of hypopigmentation. J Invest Dermatol. 2004 Feb; 122(2):452-60.
  8. Nguyen T, Novak EK, Kermani M, Fluhr J, Peters LL, Swank RT, Wei ML. Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development. J Invest Dermatol. 2002 Nov; 119(5):1156-64.
  9. Wei ML, Bonzelius F, Scully RM, Kelly RB, Herman GA. GLUT4 and transferrin receptor are differentially sorted along the endocytic pathway in CHO cells. J Cell Biol. 1998 Feb 9; 140(3):565-75.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.