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Mark Schumacher, M.D.

Anesthesiologist

Additional Languages

French
Spanish

Education

Univ. of California San Diego 1990

Residencies

UCSF, Anesthesiology 1993

Fellowships

Cedars-Sinai Med. Ctr., Internal Medicine 1991

Selected Research and Publications

  1. Wilhelmsen K, Khakpour S, Tran A, Sheehan K, Schumacher M, Xu F, Hellman J. The Endocannabinoid/Endovanilloid N-Arachidonoyl Dopamine (NADA) and Synthetic Cannabinoid WIN55,212-2 Abate the Inflammatory Activation of Human Endothelial Cells. J Biol Chem. 2014 May 9; 289(19):13079-100.
  2. Zavala K, Lee J, Chong J, Sharma M, Eilers H, Schumacher MA. The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons. Neurosci Lett. 2014 Aug 22; 578:211-6.
  3. Schumacher MA. Back pain and the mineralocorticoid receptor: is there a connection? Anesthesiology. 2012 Nov; 117(5):951-2.
  4. Chu C, Zavala K, Fahimi A, Lee J, Xue Q, Eilers H, Schumacher MA. Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons. Mol Pain. 2011; 7:44.
  5. Turnbull JH, Gebauer SL, Miller BL, Barbaro NM, Blanc PD, Schumacher MA. Cutaneous nerve transection for the management of intractable upper extremity pain caused by invasive squamous cell carcinoma. J Pain Symptom Manage. 2011 Jul; 42(1):126-33.
  6. Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW. Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction. Anesthesiology. 2010 Jun; 112(6):1452-63.
  7. Schumacher MA, Eilers H. TRPV1 splice variants: structure and function. Front Biosci (Landmark Ed). 2010; 15:872-82.
  8. Schumacher MA. Transient receptor potential channels in pain and inflammation: therapeutic opportunities. Pain Pract. 2010 May-Jun; 10(3):185-200.
  9. Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP. The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. J Neurosci. 2009 Feb 18; 29(7):2177-87.
  10. Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA. The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation. Neuroreport. 2007 Jul 2; 18(10):969-73.
  11. Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP. Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis. J Biol Chem. 2007 Jul 20; 282(29):20977-90.
  12. Xue Q, Jong B, Chen T, Schumacher MA. Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor. J Neurochem. 2007 Apr; 101(1):212-22.
  13. Eilers H, Trilk SL, Lee SY, Xue Q, Jong BE, Moff I, Levine JD, Schumacher MA. Isolation of an mRNA binding protein homologue that is expressed in nociceptors. Eur J Neurosci. 2004 Nov; 20(9):2283-93.
  14. Eilers H, Schumacher MA. Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure? Mol Interv. 2004 Aug; 4(4):197-9.
  15. Ständer S, Moormann C, Schumacher M, Buddenkotte J, Artuc M, Shpacovitch V, Brzoska T, Lippert U, Henz BM, Luger TA, Metze D, Steinhoff M. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol. 2004 Mar; 13(3):129-39.
  16. Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA. The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. Genomics. 2001 Aug; 76(1-3):14-20.
  17. Eilers H, Philip LA, Bickler PE, McKay WR, Schumacher MA. The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine. Anesth Analg. 2001 Jul; 93(1):213-4.
  18. Schumacher MA, Jong BE, Frey SL, Sudanagunta SP, Capra NF, Levine JD. The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat. Neurosci Lett. 2000 Jun 30; 287(3):215-8.
  19. Schumacher MA, Moff I, Sudanagunta SP, Levine JD. Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes. J Biol Chem. 2000 Jan 28; 275(4):2756-62.
  20. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997 Oct 23; 389(6653):816-24.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.