May 02, 2008
News Office: Kirsten Michener (415) 502-6397
Exposure to secondhand smoke even for a brief period is injurious to health, a new study by researchers at the University of California, San Francisco has found.
According to the study, a 30-minute exposure to the level of secondhand smoke that one might normally inhale in an average bar setting was enough to result in blood vessel injury in young and otherwise healthy lifelong nonsmokers. Compounding the injury to the blood vessels themselves, the exposure to smoke impedes the function of the body's natural repair mechanisms that are activated in the face of the blood vessels' injury, the researchers reported. Many of these effects persisted 24 hours later.
Study findings are reported in the online edition of the Journal of the American College of Cardiology and will appear in the journal's May 6 print issue.
The results showed that brief exposure to real-world levels of passive smoke have strong and persistent consequences on the body's vascular system, the researchers conclude.
For the study, subjects were exposed to carefully controlled levels of secondhand smoke in a research setting. The smoke was equivalent to being in a bar where smoking is allowed — as it still is for 51 percent of the U.S. population and in other countries, such as Germany — 30 minutes. As a control, the same subjects were exposed to clean air on a different day.
In both settings, the researchers evaluated the subjects' blood vessel health through ultrasound to measure blood flow and analysis of blood samples. In the exposure environment, this was done before exposure to establish baseline measures, immediately after exposure, and then one hour, 2.5 hours, and 24 hours after exposure. The study involved 10 young adult subjects between the ages of 29 and 31.
The study is the first of its kind to link injury to blood vessels with the decreased efficacy of the body's own repair mechanism, namely the endothelial progenitor cells (EPCs). EPCs are circulating stem cells in the blood that play a key role in the repair mechanism of injured blood vessels.
The researchers examined three effects of secondhand smoke exposure:
Dr. Yerem Yeghiazarians, a cardiologist at UCSF Medical Center and director of the Translational Cardiac Stem Cell Program, said, "We wanted to study whether even a brief 30 minutes of exposure to second hand smoke in otherwise healthy subjects would result in blood vessel injury and how the body's own repair mechanisms — the EPCs — would be affected by such an exposure."
The secondhand smoke's effect on all measures was profound, he says.
"Even brief secondhand smoke exposure not only resulted in blood vessel injury, but it also interfered with the body's ability to repair itself by making the EPCs dysfunctional. It is quite amazing that only 30 minutes of exposure could cause such demonstrable effects," he said. The study also showed that the deleterious effects of the exposure remain in the body for at least 24 hours, much longer than previously thought.
Study results showed that smoke exposure made EPCs less functional.
"So it's a double hit. Not only does a person develop blood vessel injury, but the cells that are supposed to help repair this damage are themselves also dysfunctional, compounding the injury," he said.
The public health implications of the study findings are significant, Yeghiazarians said. "Our study helps explain why there is about a 20 percent drop in hospital admissions for heart attacks when cities and states pass laws mandating smoke-free workplaces, restaurants and bars."
The study suggests that there is no safe level of exposure to secondhand smoke, he said.
The study was supported by awards from the Flight Attendant Medical Research Institute, American Heart Association, Wayne and Gladys Valley Foundation and UCSF Cardiac Stem Cell Foundation.
In addition to Yeghiazarians, other lead investigators on the study are Dr. Christian Heiss and Dr. Nicolas Amabile, who contributed to the work as fellows in the Division of Cardiology, Department of Medicine, at UCSF.
Other investigators in the study are Dr. Andrew C. Lee; Wendy May Real, B.S.; Suzaynn F. Schick, Ph.D.; Dr. David Lao; Maelene L. Wong, B.S.; Sarah Jahn, M.B.; Dr. Franca S. Angeli; Petros Minasi, B.A.; Matthew L. Springer, Ph.D.; Stanton Glantz, Ph.D., F.A.C.C.; Dr. William Grossman; and Dr. John Balmes all of the Department of Medicine at UCSF. S. Katharine Hammond, Ph.D., of the Division of Environmental Health Sciences, School of Public Health at UC Berkeley, also contributed to the study.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.
This news release has been modified for the website