Given America's aging population, the prevalence of trigeminal neuralgia is likely to increase. And given the pain the condition causes and its resistance to long-term cures, offering patients a full menu of treatment options is critical.
Dr. Edward Chang
It's also helpful for patients to work with experienced clinicians when sorting through their various treatment options. "High volumes matter in that discussion — and in the results patients experience," says UCSF neurosurgeon Edward Chang, M.D.. He notes that UCSF Medical Center manages more than 300 trigeminal neuralgia patients each year.
Medical management at UCSF usually begins with carbamazepine, titrated up from an initial small dose until the patient's pain is relieved. For some patients, gabapentin, baclofen and phenytoin can also be effective.
But medical management is not right for every patient, either because the pain breaks through the medication or because the side effects become too onerous. For such patients, there are multiple surgical options. Each year, physicians at UCSF treat more than 100 trigeminal neuralgia patients using one of the following procedures:
"The key is to tailor the treatment," says Chang. "What are the indications, the risks and the needs of the patient, including their willingness and ability to undergo invasive procedures?"
"Neurovascular conflict" prior to
microvascular decompression of
The most invasive procedure, microvascular decompression, is extremely effective at controlling the pain and has the best long-term results, says Chang. While very safe in experienced hands, it may not be appropriate for a patient who poses a higher surgical risk.
In other cases, the severity of symptoms and expectations of the patient determine what to use. Gamma Knife is a great noninvasive alternative, but it can result in facial numbness, and the biological effect may take some time, so if you need relief right away, it may not be the right choice," says Chang.
Thus, the value of a comprehensive center: If one procedure fails or is inappropriate for a patient's need, there are others. "You need backups and you also need smart care coordination, because even with the best treatment, this is a condition that tends to recur," says Chang. "So we partner closely with our community neurology and internist colleagues for long-term pain management. Together, we figure out how to best relieve these really suffering patients."
Refer for surgery when:
For more information, contact Dr. Edward Chang at (415) 353-2241.
How Selective Hearing Works
The longstanding mystery of how selective hearing works — how people can tune in to a single speaker while tuning out their crowded, noisy environs — was solved by two scientists from UCSF, and others at hospitals in the U.S., Canada and Europe. UCSF neurosurgeon Dr. Edward Chang and postdoctoral fellow Nima Mesgarani worked with three patients who were undergoing brain surgery for severe epilepsy.
Donors Support Neurosciences Research and Patient Care
UCSF received a challenge gift of $20 million from the Sandler Foundation that will support for the university's groundbreaking research and clinical care in neurological diseases. In honor of Herbert and Marion Sandler and the Sandler Foundation, the new neurosciences building at the UCSF Mission Bay campus will be named the Sandler Neurosciences Center.