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Paul S. Larson, M.D.

Neurosurgeon

Dr. Paul S. Larson is a neurosurgeon who specializes in the surgical treatment of movement disorders including Parkinson's disease and essential tremor, and psychiatric disorders including obsessive compulsive disorder and Tourette's syndrome. Larson sees patients in the UCSF Movement Disorders Clinic.

Larson earned a medical degree at the University of Arizona School of Medicine in 1995 and completed an internship and residency at the University of Louisville in Kentucky. His areas of research include the use of interventional MRI in deep brain stimulation surgery, the use of gene therapy to treat Parkinson's disease and the role of the basal ganglia in hearing. He is an associate professor of Neurological Surgery at UCSF, and chief of Neurosurgery and director of the Center for Advanced Neurosurgical Operative Procedures at the Veteran Affairs Medical Center in San Francisco. Larson has received two teaching awards at UCSF, authored numerous publications and edited two textbooks on functional neurosurgery.

Clinics

Surgical Movement Disorders Center
1635 Divisadero St., Suite 520
San Francisco, CA 94115
Neurology: (415) 353-2311
Neurosurgery: (415) 353-2071
Fax: (415) 353-9060

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

More about Paul S. Larson

Education

University of Arizona Medical School 1995

Residencies

University of Louisville, School of Medicine, Neurological Surgery 2001

Fellowships

University of Louisville, Surgery 1996

Selected Research and Publications

  1. Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA. Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Stereotact Funct Neurosurg. 2013; 91(2):92-103.
  2. Larson PS, Cheung SW. A stroke of silence: tinnitus suppression following placement of a deep brain stimulation electrode with infarction in area LC. J Neurosurg. 2013 Jan; 118(1):192-4.
  3. Potts MB, Larson PS. Securing Dual Ipsilateral Leads through a Single Burr Hole in Deep Brain Stimulation Surgery: Technical Note. Stereotact Funct Neurosurg. 2012; 90(6):361-4.
  4. Arjona V, Abosch A, Das P, Morton R, Hebb AO, Larson P. Comments. Neurosurgery. 2012 Jul; 71(1):192-3.
  5. Air EL, Ryapolova-Webb E, de Hemptinne C, Ostrem JL, Galifianakis NB, Larson PS, Chang EF, Starr PA. Acute effects of thalamic deep brain stimulation and thalamotomy on sensorimotor cortex local field potentials in essential tremor. Clin Neurophysiol. 2012 Nov; 123(11):2232-8.
  6. Larson PS, Starr PA, Bates G, Tansey L, Richardson RM, Martin AJ. An optimized system for interventional magnetic resonance imaging-guided stereotactic surgery: preliminary evaluation of targeting accuracy. Neurosurgery. 2012 Mar; 70(1 Suppl Operative):95-103; discussion 103.
  7. Larson PS, Cheung SW. Deep brain stimulation in area LC controllably triggers auditory phantom percepts. Neurosurgery. 2012 Feb; 70(2):398-405; discussion 405-6.
  8. Englot DJ, Glastonbury CM, Larson PS. Abnormal T2-weighted MRI signal surrounding leads in a subset of deep brain stimulation patients. Stereotact Funct Neurosurg. 2011; 89(5):311-7.
  9. Englot DJ, Chang EF, Larson PS. Lead cap localization using ultrasound in deep brain stimulation surgery: technical note. Minim Invasive Neurosurg. 2011 Feb; 54(1):48-9.
  10. Richardson RM, Kells AP, Martin AJ, Larson PS, Starr PA, Piferi PG, Bates G, Tansey L, Rosenbluth KH, Bringas JR, Berger MS, Bankiewicz KS. Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain. Stereotact Funct Neurosurg. 2011; 89(3):141-51.
  11. Shahlaie K, Larson PS, Starr PA. Intraoperative computed tomography for deep brain stimulation surgery: technique and accuracy assessment. Neurosurgery. 2011 Mar; 68(1 Suppl Operative):114-24; discussion 124.
  12. Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS. Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. Mol Ther. 2011 Jun; 19(6):1048-57.
  13. Chang EF, Cheng JS, Richardson RM, Lee C, Starr PA, Larson PS. Incidence and management of venous air embolisms during awake deep brain stimulation surgery in a large clinical series. Stereotact Funct Neurosurg. 2011 Apr; 89(2):76-82.
  14. Fiandaca MS, Salegio EA, Yin D, Richardson RM, Valles FE, Larson PS, Starr PA, Lonser RR, Bankiewicz KS. Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements. J Neurosci Methods. 2011 Mar 15; 196(1):124-30.
  15. Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson RM, Su X, Aminoff MJ, Bankiewicz KS. Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease. Neurosurgery. 2010 Nov; 67(5):1377-85.
  16. Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 2010 Dec; 9(12):1164-72.
  17. Larson PS. Minimally invasive surgery for movement disorders. Neurosurg Clin N Am. 2010 Oct; 21(4):691-8, vii.
  18. Cheung SW, Larson PS. Tinnitus modulation by deep brain stimulation in locus of caudate neurons (area LC). Neuroscience. 2010 Sep 15; 169(4):1768-78.
  19. Starr PA, Martin AJ, Ostrem JL, Talke P, Levesque N, Larson PS. Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy. J Neurosurg. 2010 Mar; 112(3):479-90.
  20. Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ. Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology. 2009 Nov 17; 73(20):1662-9.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.

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