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Rajni Sethi, M.D.

Radiation cancer specialist

Dr. Rajni A. Sethi is a radiation oncologist who treats patients with breast and gynecologic cancer. She specializes in the use of radiation treatments such as intensity-modulated radiation therapy (IMRT), stereotactic radiosurgery, stereotactic body radiotherapy, intraoperative radiation therapy (IORT), brachytherapy and hyperthermia.

In her research, she is interested in developing treatments to combine targeted biologic agents with radiotherapy as a form of personalized radiotherapy for women with breast cancer and gynecologic malignancies. She has studied the use of advanced radiotherapy with alternative patient positioning and treatment schedules to optimize radiation delivery, reduce side effects and improve the patient experience. Sethi earned a medical degree at UC San Diego School of Medicine and completed a residency in radiation oncology at New York University. She is an assistant adjunct professor of clinical radiation oncology at UCSF.


Carol Franc Buck Breast Care Center
1600 Divisadero St., Second Floor
San Francisco, CA 94115
Phone: (415) 353-7070
Surgery Fax: (415) 353-7050
Oncology Fax: (415) 353-7692

Hours: Monday to Friday
8 a.m. – 5 p.m.

Radiation Oncology at Mount Zion
1600 Divisadero St., Basement Level
San Francisco, CA 94143-1708
Main Phone: (415) 353-7175
New Patient Appointments: (415) 353-9807
Fax: (415) 353-9884

Hours: Monday to Friday
7 a.m. – 6 p.m.

Conditions & Treatments

More about Rajni Sethi


University of California San Diego School of Medicine 2007


New York University Medical Center, Radiation Oncology 2012

Selected Research and Publications

  1. Cunha JA, Mellis K, Sethi R, Siauw T, Sudhyadhom A, Garg A, Goldberg K, Hsu IC, Pouliot J. Evaluation of PC-ISO for Customized, 3D Printed, Gynecologic 192-Ir HDR Brachytherapy Applicators. J Appl Clin Med Phys. 2015; 16(1):5168.
  2. Sethi R, Park C, Fowble B. Postmastectomy radiotherapy in patients with breast cancer. Lancet. 2014 Nov 22; 384(9957):1845.
  3. Rocchi L, Pacilli A, Sethi R, Penzo M, Schneider RJ, Treré D, Brigotti M, Montanaro L. Dyskerin depletion increases VEGF mRNA internal ribosome entry site-mediated translation. Nucleic Acids Res. 2013 Sep; 41(17):8308-18.
  4. Sethi RA, Jozsef G, Grew D, Marciscano A, Pennell R, Babcock M, McCarthy A, Curtin J, Schiff PB. Is there a role for an external beam boost in cervical cancer radiotherapy? Front Oncol. 2013; 3:3.
  5. Sethi RA, No HS, Jozsef G, Ko JP, Formenti SC. Comparison of three-dimensional versus intensity-modulated radiotherapy techniques to treat breast and axillary level III and supraclavicular nodes in a prone versus supine position. Radiother Oncol. 2012 Jan; 102(1):74-81.
  6. Simpson DR, Einck JP, Nath SK, Sethi RA, Wang JZ, Mundt AJ, Sandhu AP. Comparison of daily cone-beam computed tomography and kilovoltage planar imaging for target localization in prostate cancer patients following radical prostatectomy. Pract Radiat Oncol. 2011 Jul-Sep; 1(3):156-62.
  7. Sethi R, Allen J, Donahue B, Karajannis M, Gardner S, Wisoff J, Kunnakkat S, Mathew J, Zagzag D, Newman K, Narayana A. Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma. J Neurooncol. 2011 Mar; 102(1):121-7.
  8. Sethi RA, Stamell EF, Price L, DeLacure M, Sanfilippo N. Head and neck radiotherapy compliance in an underserved patient population. Laryngoscope. 2010 Jul; 120(7):1336-41.
  9. Sethi R, Sanfilippo N. Six-month depot formulation of leuprorelin acetate in the treatment of prostate cancer. Clin Interv Aging. 2009; 4:259-67.
  10. Sandhu A, Sethi R, Rice R, Wang JZ, Marcus L, Salem C, Downs T, Parsons JK, Millard F, Pawlicki T, Mundt A. Prostate bed localization with image-guided approach using on-board imaging: reporting acute toxicity and implications for radiation therapy planning following prostatectomy. Radiother Oncol. 2008 Jul; 88(1):20-5.
  11. Sethi R, Barshop B, Stucky ER. Vomiting-again? J Hosp Med. 2007 May; 2(3):189-93.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.