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Randall James Lee, Ph.D., M.D.

Cardiologist and electrophysiologist

Dr. Randall J. Lee graduated from UCLA Medical School in 1984 where he also obtained his doctorate in pharmacology. After completing an internal medicine residency at Harbor-UCLA Medical Center in Torrance, Calif., he completed a cardiology fellowship and postdoctoral fellowship in biochemistry and molecular biology at Stanford University, where he earned a Physician Scientist Award and the Upjohn Young Investigator Award in cardiology. Lee subspecialized in cardiac electrophysiology during his second fellowship at UCSF.

His research focuses on cellular and molecular aspects of cardiac arrhythmias and vascular regeneration. He is investigating the cellular and molecular derangements that occur during cardiac arrhythmias and myocardial infarctions. Lee uses genetic engineering techniques to investigate derangements during cardiac arrhythmias and myocardial infarctions and as possible therapeutic tools. Lee also is interested in cardiac development of the conduction system and the means to alter conduction, which then may be applied to diseased states.

Clinics

Asian Heart and Vascular Center
1600 Divisadero St., Second Floor, Suite C-244
San Francisco, CA 94115
Appointments: (415) 885-3678
Events: (415) 885-3678
Fax: (415) 885-3676

Cardiac Electrophysiology and Arrhythmia Service
400 Parnassus Ave., Floor B1, Room 094
San Francisco, CA 94143
Phone: (415) 353-2554
Fax: (415) 353-2528

Hours: Monday to Friday
8 a.m. – 5 p.m.

Cardiovascular Genetics Program
400 Parnassus Avenue, Plaza Level, Room 94
San Francisco, CA 94143
Phone: (415) 353-2873
Fax: (415) 476-5355

Hours: Monday
noon – 4 p.m

Conditions & Treatments

More about Randall James Lee

Education

UCLA School of Medicine 1984

Residencies

Harbor-UCLA Medical Center, Internal Medicine 1988

Fellowships

Stanford University Medical Center, Cardiovascular Diseases 1991

Selected Research and Publications

  1. Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML. Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants. PLoS One. 2013; 8(4):e61413.
  2. Mandyam MC, Vedantham V, Scheinman MM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Gerstenfeld EP, Olgin JE, Marcus GM. Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation. Am J Cardiol. 2012 Aug 1; 110(3):364-8.
  3. Lee RJ, Hinson A, Helgerson S, Bauernschmitt R, Sabbah HN. Polymer-based restoration of left ventricular mechanics. Cell Transplant. 2013; 22(3):529-33.
  4. Hsu JC, Friday J, Lee BK, Azadani PN, Lee RJ, Badhwar N, Tseng ZH, Olgin JE, Marcus GM. Predictors of axillary vein location for vascular access during pacemaker and defibrillator lead implantation. Pacing Clin Electrophysiol. 2011 Dec; 34(12):1585-92.
  5. Hoffmayer KS, Yang Y, Joseph S, McCabe JM, Bhave P, Hsu J, Ng RK, Lee BK, Badhwar N, Lee RJ, Tseng ZH, Olgin JE, Narayan SM, Marcus GM, Scheinman MM. Predictors of unusual ECG characteristics in cavotricuspid isthmus-dependent atrial flutter ablation. Pacing Clin Electrophysiol. 2011 Oct; 34(10):1251-7.
  6. Iwai S, Badhwar N, Markowitz SM, Stambler BS, Keung E, Lee RJ, Chung JH, Olgin JE, Scheinman MM, Lerman BB. Electrophysiologic properties of para-Hisian atrial tachycardia. Heart Rhythm. 2011 Aug; 8(8):1245-53.
  7. Mihardja SS, Yu J, Lee RJ. Extracellular matrix-derived peptides and myocardial repair. Cell Adh Migr. 2011 Mar-Apr; 5(2):111-3.
  8. Shih H, Lee B, Lee RJ, Boyle AJ. The aging heart and post-infarction left ventricular remodeling. J Am Coll Cardiol. 2011 Jan 4; 57(1):9-17.
  9. Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, Lee RJ, Bernstein HS. An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors. PLoS One. 2011; 6(1):e16004.
  10. Huang NF, Kurpinski K, Fang Q, Lee RJ, Li S. Proteomic identification of biomarkers of vascular injury. Am J Transl Res. 2011 Feb; 3(2):139-48.
  11. Bartus K, Bednarek J, Myc J, Kapelak B, Sadowski J, Lelakowski J, Yakubov SJ, Lee RJ. Feasibility of closed-chest ligation of the left atrial appendage in humans. Heart Rhythm. 2011 Feb; 8(2):188-93.
  12. Yang Y, Varma N, Badhwar N, Tanel RE, Sundara S, Lee RJ, Lee BK, Tseng ZH, Marcus GM, Kim AM, Olgin JE, Scheinman MM. Prospective observations in the clinical and electrophysiological characteristics of intra-isthmus reentry. J Cardiovasc Electrophysiol. 2010 Oct; 21(10):1099-106.
  13. Yu J, Du KT, Fang Q, Gu Y, Mihardja SS, Sievers RE, Wu JC, Lee RJ. The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials. 2010 Sep; 31(27):7012-20.
  14. Huang NF, Chu J, Lee RJ, Li S. Biophysical and chemical effects of fibrin on mesenchymal stromal cell gene expression. Acta Biomater. 2010 Oct; 6(10):3947-56.
  15. Lee RJ, Bartus K, Yakubov SJ. Catheter-based left atrial appendage (LAA) ligation for the prevention of embolic events arising from the LAA: initial experience in a canine model. Circ Cardiovasc Interv. 2010 Jun 1; 3(3):224-9.
  16. Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ. Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PLoS One. 2010; 5(4):e10384.
  17. Ding C, Gepstein L, Nguyen DT, Wilson E, Hulley G, Beaser A, Lee RJ, Olgin J. High-resolution optical mapping of ventricular tachycardia in rats with chronic myocardial infarction. Pacing Clin Electrophysiol. 2010 Jun 1; 33(6):687-95.
  18. Lee RJ. Stem cells for myocardial repair and regeneration: where are we today? Methods Mol Biol. 2010; 660:1-6.
  19. Huang NF, Lee RJ, Li S. Engineering of aligned skeletal muscle by micropatterning. Am J Transl Res. 2010; 2(1):43-55.
  20. Marcus GM, Smith LM, Ordovas K, Scheinman MM, Kim AM, Badhwar N, Lee RJ, Tseng ZH, Lee BK, Olgin JE. Intracardiac and extracardiac markers of inflammation during atrial fibrillation. Heart Rhythm. 2010; 7(2):149-54.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.