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Home > Doctors > Ronald I. Clyman

Ronald I. Clyman, M.D.

Neonatologist

Dr. Ronald Clyman is a neonatologist and an expert in the treatment of extremely premature infants. He is internationally renowned for his basic and clinical studies of the ductus arteriousus, a blood vessel that transports blood from the right side of the heart to the aorta, which is the large blood vessel that distributes blood to a baby's body while still in the womb. He has helped define the role of oxygen and prostaglandins in ductus patency and is currently studying the mechanisms leading to irreversible ductal closure. Clyman is a professor of pediatrics at the University of California, San Francisco and a member of the Cardiovascular Research Institute. He earned his medical degree at Columbia University and is board certified in pediatrics and neonatal and perinatal medicine.

More about Ronald I. Clyman

Education

Columbia University School of Medicine 1971

Selected Research and Publications

  1. Clyman RI. The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia. Semin Perinatol. 2013 Apr; 37(2):102-7.
  2. Clyman RI. Surgical ligation of the patent ductus arteriosus: treatment or morbidity? J Pediatr. 2012 Oct; 161(4):583-4.
  3. Wickremasinghe AC, Rogers EE, Piecuch RE, Johnson BC, Golden S, Moon-Grady AJ, Clyman RI. Neurodevelopmental outcomes following two different treatment approaches (early ligation and selective ligation) for patent ductus arteriosus. J Pediatr. 2012 Dec; 161(6):1065-72.
  4. Clyman RI, Couto J, Murphy GM. Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? Semin Perinatol. 2012 Apr; 36(2):123-9.
  5. Sutherland MR, Yoder BA, McCurnin D, Seidner S, Gubhaju L, Clyman RI, Black MJ. Effects of ibuprofen treatment on the developing preterm baboon kidney. Am J Physiol Renal Physiol. 2012 May 15; 302(10):F1286-92.
  6. Waleh N, Seidner S, McCurnin D, Giavedoni L, Hodara V, Goelz S, Liu BM, Roman C, Clyman RI. Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation. Pediatr Res. 2011 Oct; 70(4):332-8.
  7. Waleh N, McCurnin DC, Yoder BA, Shaul PW, Clyman RI. Patent ductus arteriosus ligation alters pulmonary gene expression in preterm baboons. Pediatr Res. 2011 Mar; 69(3):212-6.
  8. Shah NA, Hills NK, Waleh N, McCurnin D, Seidner S, Chemtob S, Clyman R. Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment. J Pediatr. 2011 Jun; 158(6):919-923.e1-2.
  9. Waleh N, Hodnick R, Jhaveri N, McConaghy S, Dagle J, Seidner S, McCurnin D, Murray JC, Ohls R, Clyman RI. Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency. Pediatr Res. 2010 Oct; 68(4):292-7.
  10. Loeliger M, Shields A, McCurnin D, Clyman RI, Yoder B, Inder TE, Rees SM. Ibuprofen treatment for closure of patent ductus arteriosus is not associated with increased risk of neuropathology. Pediatr Res. 2010 Oct; 68(4):298-302.
  11. Jhaveri N, Moon-Grady A, Clyman RI. Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment. J Pediatr. 2010 Sep; 157(3):381-7, 387.e1.
  12. Chen S, Tacy T, Clyman R. How useful are B-type natriuretic peptide measurements for monitoring changes in patent ductus arteriosus shunt magnitude? J Perinatol. 2010 Dec; 30(12):780-5.
  13. Jhaveri N, Soll RF, Clyman RI. Feeding practices and patent ductus arteriosus ligation preferences-are they related? Am J Perinatol. 2010 Sep; 27(8):667-74.
  14. Clyman R, Chemtob S. Vessel remodeling in the newborn: platelets fill the gap. Nat Med. 2010 Jan; 16(1):33-5.
  15. Reese J, Waleh N, Poole SD, Brown N, Roman C, Clyman RI. Chronic in utero cyclooxygenase inhibition alters PGE2-regulated ductus arteriosus contractile pathways and prevents postnatal closure. Pediatr Res. 2009 Aug; 66(2):155-61.
  16. Clyman R, Cassady G, Kirklin JK, Collins M, Philips JB. The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial. J Pediatr. 2009 Jun; 154(6):873-6.
  17. Waleh N, Reese J, Kajino H, Roman C, Seidner S, McCurnin D, Clyman RI. Oxygen-induced tension in the sheep ductus arteriosus: effects of gestation on potassium and calcium channel regulation. Pediatr Res. 2009 Mar; 65(3):285-90.
  18. Loeliger M, Inder TE, Dalitz PA, Cain S, Camm EJ, Yoder B, McCurnin D, Shaul PW, Clyman R, Rees SM. Developmental and neuropathological consequences of ductal ligation in the preterm baboon. Pediatr Res. 2009 Feb; 65(2):209-14.
  19. McCurnin DC, Pierce RA, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard PL, Clyman RI, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW. Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):492-500.
  20. Aranda JV, Clyman R, Cox B, Van Overmeire B, Wozniak P, Sosenko I, Carlo WA, Ward RM, Shalwitz R, Baggs G, Seth A, Darko L. A randomized, double-blind, placebo-controlled trial on intravenous ibuprofen L-lysine for the early closure of nonsymptomatic patent ductus arteriosus within 72 hours of birth in extremely low-birth-weight infants. Am J Perinatol. 2009 Mar; 26(3):235-45.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.

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