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Home > Doctors > Samuel J. Pleasure

Samuel J. Pleasure, Ph.D., M.D.

Neurologist and epilepsy specialist

Dr. Samuel J. Pleasure is a neurologist and neuroscientist specializing in the care of epilepsy patients. In his research, he studies how early brain development is disturbed leading to structural brain lesions that cause epilepsy in many patients. He has published numerous scientific papers in this area and serves as an ad hoc reviewer for many scientific journals. Pleasure earned his medical degree and doctorate in neuroscience from the University of Pennsylvania. At UCSF, he completed a residency in neurology and served as chief resident for one year, followed by a research fellowship in neuroscience. Pleasure joined the faculty at UCSF as assistant professor in residence and the Robert and Elinor Aird Endowed Chair of Neurology in 2000. He is a member of the American Neurological Association, the American Academy of Neurology, American Epilepsy Society, Society for Neuroscience, Society for Developmental Biology and Cajal Club. He is a John Merck Scholar in the Biology of Developmental Disabilities in Children and is board certified by the American Board of Psychiatry and Neurology.

Clinics

Epilepsy Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2437
Fax: (415) 353-2837

Hours: Monday to Friday
8 a.m. – 5 p.m.

Multiple Sclerosis Center
1500 Owens St., Suite 320
San Francisco, CA 94158
Phone: (415) 353-2069
Fax: (415) 353-2633

Hours: Monday to Friday
8:30 a.m. – 4:30 p.m.

Conditions & Treatments

More about Samuel J. Pleasure

Education

University of Pennsylvania School of Medicine 1993

Residencies

UCSF Medical Center, Neurology 1997

Selected Research and Publications

  1. Choe Y, Kozlova A, Graf D, Pleasure SJ. Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci. 2013 Apr 17; 33(16):6766-75.
  2. Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ. CoupTFI Interacts with Retinoic Acid Signaling during Cortical Development. PLoS One. 2013; 8(3):e58219.
  3. Huilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner RF, Meyer G, Ohshima T, Pleasure SJ, Zhao Y, Tole S. Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nat Neurosci. 2013 Jan 6; 16(2):157-65.
  4. Choe Y, Pleasure SJ. Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression. Dev Neurosci. 2012; 34(6):502-14.
  5. Choe Y, Pleasure SJ. The GAP between axon pruning and repulsion. Dev Cell. 2012 Jul 17; 23(1):3-4.
  6. Harrison-Uy SJ, Pleasure SJ. Wnt signaling and forebrain development. Cold Spring Harb Perspect Biol. 2012 Jul; 4(7):a008094.
  7. Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron. 2012 Mar 22; 73(6):1127-42.
  8. Choe Y, Siegenthaler JA, Pleasure SJ. A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. Neuron. 2012 Feb 23; 73(4):698-712.
  9. Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BS, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):E423-31.
  10. Zarbalis K, Choe Y, Siegenthaler JA, Orosco LA, Pleasure SJ. Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice. Neural Dev. 2012; 7:2.
  11. Gu X, Liu B, Wu X, Yan Y, Zhang Y, Wei Y, Pleasure SJ, Zhao C. Inducible genetic lineage tracing of cortical hem derived Cajal-Retzius cells reveals novel properties. PLoS One. 2011; 6(12):e28653.
  12. Li Y, Tian C, Yang Y, Yan Y, Ni Y, Wei Y, Pleasure SJ, Zhao C. An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis. Genesis. 2011 Dec; 49(12):919-26.
  13. Pino D, Choe Y, Pleasure SJ. Wnt5a controls neurite development in olfactory bulb interneurons. ASN Neuro. 2011; 3(3):e00059.
  14. Li G, Pleasure SJ. Exciting information for inhibitory neurons. Neuron. 2011 Feb 24; 69(4):585-7.
  15. Munji RN, Choe Y, Li G, Siegenthaler JA, Pleasure SJ. Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors. J Neurosci. 2011 Feb 2; 31(5):1676-87.
  16. Siegenthaler JA, Pleasure SJ. We have got you 'covered': how the meninges control brain development. Curr Opin Genet Dev. 2011 Jun; 21(3):249-55.
  17. Wang Y, Li G, Stanco A, Long JE, Crawford D, Potter GB, Pleasure SJ, Behrens T, Rubenstein JL. CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron. 2011 Jan 13; 69(1):61-76.
  18. Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ. Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21795-800.
  19. Langseth AJ, Munji RN, Choe Y, Huynh T, Pozniak CD, Pleasure SJ. Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon. J Neurosci. 2010 Oct 6; 30(40):13367-72.
  20. Hecht JH, Siegenthaler JA, Patterson KP, Pleasure SJ. Primary cellular meningeal defects cause neocortical dysplasia and dyslamination. Ann Neurol. 2010 Oct; 68(4):454-64.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.

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