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Spencer Yost, M.D.

Medical director of intensive care at Mount Zion

Dr. Spencer Yost is chief of Anesthesia at UCSF Medical Center at Mount Zion and medical director of the six-bed Intensive Care Unit at the Mount Zion hospital.

Yost earned a medical degree at UCSF and completed an anesthesia residency at Harbor-UCLA Medical Center, an affiliate of the UCLA School of Medicine. He completed a fellowship in critical care medicine at Presbyterian Hospital, an affiliate of the University of Pittsburgh School of Medicine. Yost is a professor and vice chair of Anesthesia and Perioperative Care at UCSF.

More about Spencer Yost


UCSF 1983


Harbor-UCLA Medical Center, Anesthesiology 1986


Presbyterian Hospital, University of Pittsburgh, Critical Care Medicine 1987

Selected Research and Publications

  1. Chae YJ, Zhang J, Au P, Sabbadini M, Xie GX, Yost CS. Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK. Anesthesiology. 2010 Dec; 113(6):1326-37.
  2. Anderson A, Eilers H, Yost CS. Anaphylaxis complicating graft reperfusion during orthotopic liver transplantation: a case report. Transplant Proc. 2010 Jun; 42(5):1967-9.
  3. Kopp Lugli A, Yost CS, Kindler CH. Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia. Eur J Anaesthesiol. 2009 Oct; 26(10):807-20.
  4. Yoo S, Liu J, Sabbadini M, Au P, Xie GX, Yost CS. Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system. Neurosci Lett. 2009 Nov 6; 465(1):79-84.
  5. Sabbadini M, Yost CS. Molecular biology of background K channels: insights from K(2P) knockout mice. J Mol Biol. 2009 Feb 6; 385(5):1331-44.
  6. Yost CS, Gropper MA. The curse of the drinking class. Crit Care Med. 2008 Jun; 36(6):1958-9.
  7. Yost CS, Oh I, Eger EI, Sonner JM. Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity. Behav Brain Res. 2008 Nov 21; 193(2):192-6.
  8. Yost CS. A new look at the respiratory stimulant doxapram. CNS Drug Rev. 2006 Fall-Winter; 12(3-4):236-49.
  9. Brosnan R, Gong D, Cotten J, Keshavaprasad B, Yost CS, Eger EI, Sonner JM. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Anesth Analg. 2006 Jul; 103(1):86-91, table of contents.
  10. Cotten JF, Keshavaprasad B, Laster MJ, Eger EI, Yost CS. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg. 2006 Mar; 102(3):779-85.
  11. Keshavaprasad B, Liu C, Au JD, Kindler CH, Cotten JF, Yost CS. Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK. Anesth Analg. 2005 Oct; 101(4):1042-9, table of contents.
  12. Paul M, Callahan R, Au J, Kindler CH, Yost CS. Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors. Anesth Analg. 2005 Sep; 101(3):715-21, table of contents.
  13. Kindler CH, Yost CS. Two-pore domain potassium channels: new sites of local anesthetic action and toxicity. Reg Anesth Pain Med. 2005 May-Jun; 30(3):260-74.
  14. Liu C, Cotten JF, Schuyler JA, Fahlman CS, Au JD, Bickler PE, Yost CS. Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress. Brain Res. 2005 Jan 21; 1031(2):164-73.
  15. Liu C, Au JD, Zou HL, Cotten JF, Yost CS. Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics. Anesth Analg. 2004 Dec; 99(6):1715-22, table of contents.
  16. Cotten JF, Zou HL, Liu C, Au JD, Yost CS. Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2). Brain Res Mol Brain Res. 2004 Sep 28; 128(2):112-20.
  17. Callahan R, Labunskiy DA, Logvinova A, Abdallah M, Liu C, Cotten JF, Yost CS. Immunolocalization of TASK-3 (KCNK9) to a subset of cortical neurons in the rat CNS. Biochem Biophys Res Commun. 2004 Jun 25; 319(2):525-30.
  18. Callahan RJ, Au JD, Paul M, Liu C, Yost CS. Functional inhibition by methadone of N-methyl-D-aspartate receptors expressed in Xenopus oocytes: stereospecific and subunit effects. Anesth Analg. 2004 Mar; 98(3):653-9, table of contents.
  19. Mhatre AN, Li J, Chen AF, Yost CS, Smith RJ, Kindler CH, Lalwani AK. Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4. J Neurosci Res. 2004 Jan 1; 75(1):25-31.
  20. Yost CS. Update on tandem pore (2P) domain K+ channels. Curr Drug Targets. 2003 May; 4(4):347-51.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.