University of California San Francisco | About UCSF | UCSF Benioff Children's Hospital San Francisco
Search Site | Find a Doctor

CSF VDRL Test

Definition

The CSF-VDRL test is used to diagnose neurosyphilis. This test looks for antibodies called reagins, which are sometimes produced by the body in reaction to the syphilis-causing bacteria.

See also: VDRL

Alternative Names

Venereal disease research laboratory slide test - CSF

How the test is performed

The test is performed on a CSF sample obtained by lumbar puncture (spinal tap).

How to prepare for the test

Before the procedure, you will be asked to review the risks and sign a consent form.

How the test will feel

Usually, discomfort associated with the lumbar puncture is mild to moderate. The entire procedure usually takes about 30 minutes but may take longer. The actual fluid collection only takes a few minutes.

Why the test is performed

The CSF-VDRL test is used to diagnose syphilis in the brain or spinal cord. Brain and spinal cord involvement usually indicates late stage (tertiary) syphilis.

Blood screening tests, such as VDRL and RPR, are more effective during middle stage (secondary) syphilis.

Normal Values

A negative result is normal.

However, false-negatives can occur. This means you can have syphilis and have a normal CSF-VDRL test result. Therefore, a negative test does not always rule out the disease. Other markers of inflammation, such as elevated protein levels or excess white blood cells, may be used to diagnose neurosyphilis.

What abnormal results mean

A positive result is abnormal and indicates neurosyphilis.

What the risks are

Risks of lumbar puncture include:

  • Hypersensitivity (allergic) reaction to the anesthetic
  • Discomfort during the test
  • Headache after the test
  • Bleeding into the spinal canal
  • Brain herniation (if performed on a person with increased intracranial pressure) which may result in brain damage or death
  • Damage to the spinal cord or nerve roots

References

Hook EW III. Syphilis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 340.

Fletcher JJ, Nathan BR. Cerebrospinal fluid and intracranial pressure. In: Goetz, CG, eds. Textbook of Clinical Neurology. 3rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 26.

Review Date: 7/27/2009

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright ©2010 A.D.A.M., Inc., as modified by University of California San Francisco. Any duplication or distribution of the information contained herein is strictly prohibited.

Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Medical Center. Please discuss with your doctor any questions or concerns you may have.