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Wade Smith, Ph.D., M.D.

Director of Neurovascular Services

Dr. Wade Smith, director of the UCSF Neurovascular Service, specializes in stroke prevention, the management of acute stroke, critical care medicine, cerebral blood-flow monitoring with transcranial Doppler techniques and the medical management of patients after stroke. As a neurointensivist trained in both critical care and neurology, he directs the UCSF Neurological Intensive Care Unit, a 16-bed ICU dedicated to the care and resuscitation of patients with neurological injury. Many of the patients he evaluates are referred for a second or third opinion, but he also sees patients on primary referral.

Smith earned a medical degree along with a doctorate in neurophysiology from the University of Washington. He completed a residency as well as a fellowship in critical care medicine at the University of California, San Francisco.


Neurovascular Disease and Stroke Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-8897
Fax: (415) 353-8705

Hours: Monday to Friday
8:30 a.m. – 5 p.m.

Vascular Laboratories at Parnassus
505 Parnassus Ave., Eighth Floor, Room M-830A
San Francisco, CA 94143
Phone: (415) 353-1286
Fax: (415) 353-8706

Hours: Monday to Friday
9 a.m. – 5:30 p.m.

Conditions & Treatments

More about Wade Smith


University of Washington 1989


UCSF, Neurology 1993


UCSF, Critical Care 1994

Selected Research and Publications

  1. Flint AC, Rao VA, Chan SL, Cullen SP, Faigeles BS, Smith WS, Bath PM, Wahlgren N, Ahmed N, Donnan GA, Johnston SC. Improved ischemic stroke outcome prediction using model estimation of outcome probability: The THRIVE-c calculation. Int J Stroke. 2015 Aug; 10(6):815-21.
  2. Smith WS, Browne JL, Ko NU. Cranial Accelerometry Can Detect Cerebral Vasospasm Caused by Subarachnoid Hemorrhage. Neurocrit Care. 2015 Mar 12.
  3. Auerbach PS, Baine JG, Schott ML, Greenhaw A, Acharya MG, Smith WS. Detection of concussion using cranial accelerometry. Clin J Sport Med. 2015 Mar; 25(2):126-32.
  4. Zaidat OO, Fitzsimmons BF, Woodward BK, Wang Z, Killer-Oberpfalzer M, Wakhloo A, Gupta R, Kirshner H, Megerian JT, Lesko J, Pitzer P, Ramos J, Castonguay AC, Barnwell S, Smith WS, Gress DR. Effect of a balloon-expandable intracranial stent vs medical therapy on risk of stroke in patients with symptomatic intracranial stenosis: the VISSIT randomized clinical trial. JAMA. 2015 Mar 24-31; 313(12):1240-8.
  5. Chan S, Josephson SA, Rosow L, Smith WS. A quality assurance initiative targeting radiation exposure to neuroscience patients in the intensive care unit. Neurohospitalist. 2015 Jan; 5(1):9-14.
  6. Guterman EL, Kamel H, Azran C, Shah MP, Claude Hemphill J, Smith WS, Navi BB. Time from onset of SIRS to antibiotic administration and outcomes after subarachnoid hemorrhage. Neurocrit Care. 2014 Aug; 21(1):85-90.
  7. Flint AC, Gupta R, Smith WS, Kamel H, Faigeles BS, Cullen SP, Rao VA, Bath PM, Wahlgren N, Ahmed N, Donnan GA. The THRIVE score predicts symptomatic intracerebral hemorrhage after intravenous tPA administration in SITS-MOST. Int J Stroke. 2014 Aug; 9(6):705-10.
  8. Shi ZS, Liebeskind DS, Xiang B, Ge SG, Feng L, Albers GW, Budzik R, Devlin T, Gupta R, Jansen O, Jovin TG, Killer-Oberpfalzer M, Lutsep HL, Macho J, Nogueira RG, Rymer M, Smith WS, Wahlgren N, Duckwiler GR. Predictors of functional dependence despite successful revascularization in large-vessel occlusion strokes. Stroke. 2014 Jul; 45(7):1977-84.
  9. Liebeskind DS, Flint AC, Budzik RF, Xiang B, Smith WS, Duckwiler GR, Nogueira RG. Carotid I's, L's and T's: collaterals shape the outcome of intracranial carotid occlusion in acute ischemic stroke. J Neurointerv Surg. 2015 Jun; 7(6):402-7.
  10. Alexander MD, Meyers PM, English JD, Stradford TR, Sung S, Smith WS, Halbach VV, Higashida RT, Dowd CF, Cooke DL, Hetts SW. Symptom differences and pretreatment asymptomatic interval affect outcomes of stenting for intracranial atherosclerotic disease. AJNR Am J Neuroradiol. 2014 Jun; 35(6):1157-62.
  11. Lima FO, Furie KL, Silva GS, Lev MH, Camargo EC, Singhal AB, Harris GJ, Halpern EF, Koroshetz WJ, Smith WS, Nogueira RG. Prognosis of untreated strokes due to anterior circulation proximal intracranial arterial occlusions detected by use of computed tomography angiography. JAMA Neurol. 2014 Feb; 71(2):151-7.
  12. Saver JL, Jovin TG, Smith WS, Albers GW, Baron JC, Boltze J, Broderick JP, Davis LA, Demchuk AM, DeSena S, Fiehler J, Gorelick PB, Hacke W, Holt B, Jahan R, Jing H, Khatri P, Kidwell CS, Lees KR, Lev MH, Liebeskind DS, Luby M, Lyden P, Megerian JT, Mocco J, Muir KW, Rowley HA, Ruedy RM, Savitz SI, Sipelis VJ, Shimp SK, Wechsler LR, Wintermark M, Wu O, Yavagal DR, Yoo AJ. Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices. Stroke. 2013 Dec; 44(12):3596-601.
  13. Flint AC, Faigeles BS, Cullen SP, Kamel H, Rao VA, Gupta R, Smith WS, Bath PM, Donnan GA. THRIVE score predicts ischemic stroke outcomes and thrombolytic hemorrhage risk in VISTA. Stroke. 2013 Dec; 44(12):3365-9.
  14. Flint AC, Xiang B, Gupta R, Nogueira RG, Lutsep HL, Jovin TG, Albers GW, Liebeskind DS, Sanossian N, Smith WS. THRIVE score predicts outcomes with a third-generation endovascular stroke treatment device in the TREVO-2 trial. Stroke. 2013 Dec; 44(12):3370-5.
  15. González RG, Furie KL, Goldmacher GV, Smith WS, Kamalian S, Payabvash S, Harris GJ, Halpern EF, Koroshetz WJ, Camargo EC, Dillon WP, Lev MH. Good outcome rate of 35% in IV-tPA-treated patients with computed tomography angiography confirmed severe anterior circulation occlusive stroke. Stroke. 2013 Nov; 44(11):3109-13.
  16. Morgenstern LB, Smith WS. Setting priorities for stroke care and research. Int J Stroke. 2013 Aug; 8(6):445-6.
  17. Zaidat OO, Castonguay AC, Fitzsimmons BF, Woodward BK, Wang Z, Killer-Oberpfalzer M, Wakhloo A, Gupta R, Kirshner H, Eliasziw M, Thomas Megerian J, Shetty S, Yoklavich Guilhermier M, Barnwell S, Smith WS, Gress DR. Design of the Vitesse Intracranial Stent Study for Ischemic Therapy (VISSIT) trial in symptomatic intracranial stenosis. J Stroke Cerebrovasc Dis. 2013 Oct; 22(7):1131-9.
  18. Navi BB, Kamel H, Hemphill JC, Smith WS. Trajectory of functional recovery after hospital discharge for subarachnoid hemorrhage. Neurocrit Care. 2012 Dec; 17(3):343-7.
  19. Kamel H, Navi BB, Elijovich L, Josephson SA, Yee AH, Fung G, Johnston SC, Smith WS. Pilot randomized trial of outpatient cardiac monitoring after cryptogenic stroke. Stroke. 2013 Feb; 44(2):528-30.
  20. Kamel H, Patel N, Rao VA, Cullen SP, Faigeles BS, Smith WS, Flint AC. The totaled health risks in vascular events (THRIVE) score predicts ischemic stroke outcomes independent of thrombolytic therapy in the NINDS tPA trial. J Stroke Cerebrovasc Dis. 2013 Oct; 22(7):1111-6.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.