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William Grossman, M.D.

Cardiologist

Dr. William Grossman is a cardiologist and director of the Center for Prevention of Heart and Vascular Disease at Mission Bay. He specializes in treatments to prevent the development or progression of heart disease and cares for patients with hypertension (high blood pressure), dyslipidemia (abnormal cholesterol), coronary artery disease (previous or recent heart attack and angina), valvular heart disease, atrial fibrillation, cardiomyopathy and heart failure.

Grossman has been a pioneer in research on diastolic function of the left ventricle and is editor of the textbook "Grossman's Cardiac Catheterization, Angiography and Intervention," which remains a standard in the field. He is the Charles and Helen Schwab Endowed Chair in Preventive Cardiology at UCSF and a former chief of Cardiology at UCSF Medical Center.

Clinics

Cardiovascular Care and Prevention Center at Mission Bay
535 Mission Bay Blvd. South
San Francisco, CA 94158
Phone: (415) 353-2873
Fax: (415) 353-2528

Hours: Monday to Friday
8 a.m. – 5 p.m.

Center for Prevention of Heart and Vascular Disease
535 Mission Bay Blvd. South
San Francisco, CA 94158
Phone: (415) 353-2873
Fax: (415) 353-2528
Follow-up: (415) 412-9635

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

More about William Grossman

Education

Yale University School of Medicine 1965

Residencies

Peter Bent Brigham Hospital, Internal Medicine 1969

Fellowships

Peter Bent Brigham Hospital, Cardiology 1971

Selected Research and Publications

  1. Grossman W, Paulus WJ. Myocardial stress and hypertrophy: a complex interface between biophysics and cardiac remodeling. J Clin Invest. 2013 Sep 3; 123(9):3701-3.
  2. Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS One. 2012; 7(1):e30329.
  3. Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, Grayson MH, Verbsky JW. Granzyme B regulates antiviral CD8+ T cell responses. J Immunol. 2011 Dec 15; 187(12):6301-9.
  4. Prochaska JJ, Benowitz NL, Glantz SA, Hudmon KS, Grossman W. Cardiology Rx for Change: improving clinical attention to tobacco use and secondhand smoke exposure in cardiology. Clin Cardiol. 2011 Dec; 34(12):738-43.
  5. Angeli FS, Amabile N, Shapiro M, Mirsky R, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Cytokine combination therapy with erythropoietin and granulocyte colony stimulating factor in a porcine model of acute myocardial infarction. Cardiovasc Drugs Ther. 2010 Dec; 24(5-6):409-20.
  6. Heiss C, Schanz A, Amabile N, Jahn S, Chen Q, Wong ML, Rassaf T, Heinen Y, Cortese-Krott M, Grossman W, Yeghiazarians Y, Springer ML. Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2212-8.
  7. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovasc Pathol. 2011 Jul-Aug; 20(4):204-12.
  8. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010 Jul 13; 56(3):218-24.
  9. Angeli FS, Smith C, Amabile N, Shapiro M, Bartlett L, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction. Cytokine. 2010 Sep; 51(3):278-85.
  10. Tomita-Mitchell A, Mahnke DK, Larson JM, Ghanta S, Feng Y, Simpson PM, Broeckel U, Duffy K, Tweddell JS, Grossman WJ, Routes JM, Mitchell ME. Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease. Physiol Genomics. 2010 Sep; 42A(1):52-60.
  11. Kelly ME, Juern AM, Grossman WJ, Schauer DW, Drolet BA. Immunosuppressive effects in infants treated with corticosteroids for infantile hemangiomas. Arch Dermatol. 2010 Jul; 146(7):767-74.
  12. Yeghiazarians Y, Khan M, Angeli FS, Zhang Y, Jahn S, Prasad M, Mirsky R, Shih H, Minasi P, Boyle A, Grossman W. Cytokine combination therapy with long-acting erythropoietin and granulocyte colony stimulating factor improves cardiac function but is not superior than monotherapy in a mouse model of acute myocardial infarction. J Card Fail. 2010 Aug; 16(8):669-78.
  13. Angeli FS, Amabile N, Burjonroppa S, Shapiro M, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Prolonged therapy with erythropoietin is safe and prevents deterioration of left ventricular systolic function in a porcine model of myocardial infarction. J Card Fail. 2010 Jul; 16(7):579-89.
  14. Amabile N, Heiss C, Chang V, Angeli FS, Damon L, Rame EJ, McGlothlin D, Grossman W, De Marco T, Yeghiazarians Y. Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients. J Heart Lung Transplant. 2009 Oct; 28(10):1081-6.
  15. Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H. Combining angiogenic gene and stem cell therapies for myocardial infarction. J Gene Med. 2009 Sep; 11(9):743-53.
  16. Angeli FS, Shapiro M, Amabile N, Orcino G, Smith CS, Tacy T, Boyle AJ, Chatterjee K, Glantz SA, Grossman W, Yeghiazarians Y. Left ventricular remodeling after myocardial infarction: characterization of a swine model on beta-blocker therapy. Comp Med. 2009 Jun; 59(3):272-9.
  17. Michaels AD, Tacy T, Teitel D, Shapiro M, Grossman W. Invasive left ventricular energetics during enhanced external counterpulsation. Am J Ther. 2009 May-Jun; 16(3):239-46.
  18. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009 Jul; 17(7):1250-6.
  19. Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H. VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun. 2008 Nov 14; 376(2):419-22.
  20. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008 May 6; 51(18):1760-71.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.