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William Hoffman, M.D.

Chief of Plastic and Reconstructive Surgery

Dr. William Hoffman, chief of Plastic and Reconstructive Surgery at UCSF Medical Center and UCSF Benioff Children's Hospital, is a specialist in pediatric plastic surgery. His area of expertise includes the treatment of children with congenital and acquired deformities, such as cleft lip and palate, craniosynostosis and other craniofacial syndromes, hemangioma and vascular anomalies, and giant nevi. His research interests include fetal cleft repairs, gene expression in hemangioma and outcomes of specific procedures for cleft palate.

Hoffman is a graduate of Yale University and earned a medical degree at the University of Rochester School of Medicine and Dentistry. He trained in general surgery and plastic surgery at the University of California, San Francisco and completed a fellowship in craniofacial surgery at the Institute of Reconstructive Plastic Surgery at New York University. Hoffman is a professor of clinical surgery at UCSF.


Birthmarks & Vascular Anomalies Center
1701 Divisadero St.
San Francisco, CA 94115
Appointments: (415) 353–7823
Clinic: (415) 353–7800
Fax: (415) 353–7478

Hours: First Friday of the month, 8 a.m. – noon

Plastic and Reconstructive (Cosmetic) Surgery
350 Parnassus Ave., Suite 509
San Francisco, CA 94143-0932
Phone: (415) 353-4201
Fax: (415) 353-4622

Hours: Monday to Friday
8 a.m. – 5 p.m.

Plastic and Reconstructive (Non-Cosmetic) Surgery
400 Parnassus Ave., Suite A-655
San Francisco, CA 94143-0932
Phone: (415) 353-4201
Fax: (415) 353-4330

Hours: Monday to Friday
8 a.m. – 4:30 p.m.

Conditions & Treatments

More about William Hoffman


University of Rochester School of Medicine 1977


UCSF Medical Center, General Surgery 1983
UCSF Medical Center, Plastic Surgery 1985


Institute of Reconstructive Plastic Surgery, New York University, Craniofacial Surgery 1986

Selected Research and Publications

  1. Xu X, Wilschut KJ, Kouklis G, Tian H, Hesse R, Garland C, Sbitany H, Hansen S, Seth R, Knott PD, Hoffman WY, Pomerantz JH. Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles. Stem Cell Reports. 2015 Sep 8; 5(3):419-34.
  2. Koo KS, Dowd CF, Mathes EF, Rosbe KW, Hoffman WY, Frieden IJ, Hess CP. MRI phenotypes of localized intravascular coagulopathy in venous malformations. Pediatr Radiol. 2015 Oct; 45(11):1690-5.
  3. Patel AS, Schulman JM, Ruben BS, Hoffman WY, Dowd CF, Frieden IJ, Hess CP. Atypical MRI features in soft-tissue arteriovenous malformation: a novel imaging appearance with radiologic-pathologic correlation. Pediatr Radiol. 2015 Sep; 45(10):1515-21.
  4. Daniels KM, Yu EY, Maine RG, Corlew S, Bing S, Hoffman WY, Gregory GA. Palatal fistula risk after primary palatoplasty: a retrospective comparison of humanitarian operations and tertiary hospitals. Lancet. 2015 Apr 27; 385 Suppl 2:S37.
  5. Wang ED, Conkling N, Xu X, Chern H, Finlayson E, Varma MG, Hansen SL, Foster RD, Hoffman WY, Sbitany H. Perineal Flap Reconstruction following Oncologic Anorectal Extirpation: An Outcomes Assessment. Plast Reconstr Surg. 2015 Jan; 135(1):176e-84e.
  6. Nguyen JT, Koerper MA, Hess CP, Dowd CF, Hoffman WY, Dickman M, Frieden IJ. Aspirin therapy in venous malformation: a retrospective cohort study of benefits, side effects, and patient experiences. Pediatr Dermatol. 2014 Sep-Oct; 31(5):556-60.
  7. Sbitany H, Xu X, Hansen SL, Young DM, Hoffman WY. The effects of immunosuppressive medications on outcomes in microvascular free tissue transfer. Plast Reconstr Surg. 2014 Apr; 133(4):552e-8e.
  8. Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD. Memory regulatory T cells reside in human skin. J Clin Invest. 2014 Mar 3; 124(3):1027-36.
  9. Vogel SA, Hess CP, Dowd CF, Hoffman WY, Kane AJ, Rajaii R, Frieden IJ. Early versus later presentations of venous malformations: where and why? Pediatr Dermatol. 2013 Sep-Oct; 30(5):534-40.
  10. Oberoi S, Hoffman WY, Chigurupati R, Vargervik K. Frequency of surgical correction for maxillary hypoplasia in cleft lip and palate. J Craniofac Surg. 2012 Nov; 23(6):1665-7.
  11. Ohtani J, Hoffman WY, Vargervik K, Oberoi S. Team management and treatment outcomes for patients with hemifacial microsomia. Am J Orthod Dentofacial Orthop. 2012 Apr; 141(4 Suppl):S74-81.
  12. Oberoi S, Hoffman WY, Vargervik K. Craniofacial team management in Apert syndrome. Am J Orthod Dentofacial Orthop. 2012 Apr; 141(4 Suppl):S82-7.
  13. Maine RG, Hoffman WY, Palacios-Martinez JH, Corlew DS, Gregory GA. Comparison of fistula rates after palatoplasty for international and local surgeons on surgical missions in Ecuador with rates at a craniofacial center in the United States. Plast Reconstr Surg. 2012 Feb; 129(2):319e-326e.
  14. Chang EI, Leon P, Hoffman WY, Schmidt BL. Quality of life for patients requiring surgical resection and reconstruction for mandibular osteoradionecrosis: 10-year experience at the University of California San Francisco. Head Neck. 2012 Feb; 34(2):207-12.
  15. Chang EI, Galvez MG, Padilla BE, Freise CE, Foster RD, Hoffman WY. Ten-year retrospective analysis of incisional herniorrhaphy following renal transplantation. Arch Surg. 2011 Jan; 146(1):21-5.
  16. Maguiness SM, Hoffman WY, McCalmont TH, Frieden IJ. Early white discoloration of infantile hemangioma: a sign of impending ulceration. Arch Dermatol. 2010 Nov; 146(11):1235-9.
  17. Oberoi S, Gill P, Chigurupati R, Hoffman WY, Hatcher DC, Vargervik K. Three-dimensional assessment of the eruption path of the canine in individuals with bone-grafted alveolar clefts using cone beam computed tomography. Cleft Palate Craniofac J. 2010 Sep; 47(5):507-12.
  18. Paydar KZ, Hansen SL, Chang DS, Hoffman WY, Leon P. Implantable venous Doppler monitoring in head and neck free flap reconstruction increases the salvage rate. Plast Reconstr Surg. 2010 Apr; 125(4):1129-34.
  19. Vargervik K, Oberoi S, Hoffman WY. Team care for the patient with cleft: UCSF protocols and outcomes. J Craniofac Surg. 2009 Sep; 20 Suppl 2:1668-71.
  20. Oberoi S, Chigurupati R, Gill P, Hoffman WY, Vargervik K. Volumetric assessment of secondary alveolar bone grafting using cone beam computed tomography. Cleft Palate Craniofac J. 2009 Sep; 46(5):503-11.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.