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William Marks, M.D.

Director of Surgical Treatment of Movement Disorders

Dr. William Marks, a specialist in epilepsy and movement disorders, has extensive experience in treating Parkinson's disease and other movement disorders with brain stimulators. He earned a medical degree at Johns Hopkins University and completed a residency and a fellowship in neurology at UCSF Medical Center. He currently is medical director of the UCSF Center for the Surgical Treatment of Movement Disorders. At the Veterans Affairs Medical Center in San Francisco, he is director of the Parkinson's Disease Research, Education and Clinical Center and the Comprehensive Epilepsy Center.

Clinics

Epilepsy Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2437
Fax: (415) 353-2837

Hours: Monday to Friday
8 a.m. – 5 p.m.

Surgical Movement Disorders Center
1635 Divisadero St., Suite 520
San Francisco, CA 94115
Neurology: (415) 353-2311
Neurosurgery: (415) 353-2071
Fax: (415) 353-9060

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

More about William Marks

Additional Languages

German

Education

Johns Hopkins University 1991

Residencies

UCSF Medical Center, Neurology 1995

Fellowships

UCSF Medical Center, Neurology

Selected Research and Publications

  1. Markun LC, Starr PA, Air EL, Marks WJ, Volz MM, Ostrem JL. Shorter disease duration correlates with improved long-term deep brain stimulation outcomes in young-onset DYT1 dystonia. Neurosurgery. 2012 Aug; 71(2):325-30.
  2. Weaver FM, Follett KA, Stern M, Luo P, Harris CL, Hur K, Marks WJ, Rothlind J, Sagher O, Moy C, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein JM, Stoner G, Starr PA, Simpson R, Baltuch G, De Salles A, Huang GD, Reda DJ. Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes. Neurology. 2012 Jul 3; 79(1):55-65.
  3. Christine CW, Marks WJ, Ostrem JL. Development of Parkinson's disease in patients with Narcolepsy. J Neural Transm. 2012 Jun; 119(6):697-9.
  4. Zhan W, Kang GA, Glass GA, Zhang Y, Shirley C, Millin R, Possin KL, Nezamzadeh M, Weiner MW, Marks WJ, Schuff N. Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging. Mov Disord. 2012 Jan; 27(1):90-7.
  5. Witt J, Marks WJ. An update on gene therapy in Parkinson's disease. Curr Neurol Neurosci Rep. 2011 Aug; 11(4):362-70.
  6. Bronte-Stewart H, Taira T, Valldeoriola F, Merello M, Marks WJ, Albanese A, Bressman S, Moro E. Inclusion and exclusion criteria for DBS in dystonia. Mov Disord. 2011 Jun; 26 Suppl 1:S5-16.
  7. Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 2010 Dec; 9(12):1164-72.
  8. Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ, Moro E, Vitek JL, Weaver FM, Gross RE, DeLong MR. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol. 2011 Feb; 68(2):165.
  9. Follett KA, Weaver FM, Stern M, Hur K, Harris CL, Luo P, Marks WJ, Rothlind J, Sagher O, Moy C, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein JM, Stoner G, Starr PA, Simpson R, Baltuch G, De Salles A, Huang GD, Reda DJ. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. N Engl J Med. 2010 Jun 3; 362(22):2077-91.
  10. Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, DeSalles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010 May; 51(5):899-908.
  11. Berman BD, Starr PA, Marks WJ, Ostrem JL. Induction of bradykinesia with pallidal deep brain stimulation in patients with cranial-cervical dystonia. Stereotact Funct Neurosurg. 2009; 87(1):37-44.
  12. Weaver FM, Follett K, Stern M, Hur K, Harris C, Marks WJ, Rothlind J, Sagher O, Reda D, Moy CS, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein J, Stoner G, Heemskerk J, Huang GD. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA. 2009 Jan 7; 301(1):63-73.
  13. Stanslaski S, Cong P, Carlson D, Santa W, Jensen R, Molnar G, Marks WJ, Shafquat A, Denison T. An implantable bi-directional brain-machine interface system for chronic neuroprosthesis research. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:5494-7.
  14. Marks WJ, Ostrem JL, Verhagen L, Starr PA, Larson PS, Bakay RA, Taylor R, Cahn-Weiner DA, Stoessl AJ, Olanow CW, Bartus RT. Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial. Lancet Neurol. 2008 May; 7(5):400-8.
  15. Ostrem JL, Marks WJ, Volz MM, Heath SL, Starr PA. Pallidal deep brain stimulation in patients with cranial-cervical dystonia (Meige syndrome). Mov Disord. 2007 Oct 15; 22(13):1885-91.
  16. Nakamura K, Christine CW, Starr PA, Marks WJ. Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease. Mov Disord. 2007 Apr 15; 22(5):619-26.
  17. Khandhar SM, Marks WJ. Epidemiology of Parkinson's disease. Dis Mon. 2007 Apr; 53(4):200-5.
  18. Rothlind JC, Cockshott RW, Starr PA, Marks WJ. Neuropsychological performance following staged bilateral pallidal or subthalamic nucleus deep brain stimulation for Parkinson's disease. J Int Neuropsychol Soc. 2007 Jan; 13(1):68-79.
  19. Starr PA, Turner RS, Rau G, Lindsey N, Heath S, Volz M, Ostrem JL, Marks WJ. Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes. J Neurosurg. 2006 Apr; 104(4):488-501.
  20. Follett K, Weaver F, Stern M, Marks W, Hogarth P, Holloway K, Bronstein J, Duda J, Horn S, Lai E, Samii A. Multisite randomized trial of deep brain stimulation. Arch Neurol. 2005 Oct; 62(10):1643-4; author reply 1644-5.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.

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