Andrew Krystal, MD


Dr. Andrew Krystal is a neurologist who cares for adults with all types of sleep disorders, with particular expertise in insomnia. He also treats patients who have mood and anxiety spectrum disorders in addition to sleep disorders. An internationally renowned expert on sleep and mood disorders, he has more than 25 years of experience in patient care and research.

Krystal's research focuses on understanding insomnia's causes and how insomnia may be related to psychiatric or other medical conditions. He also studies new treatments for insomnia and other sleep disorders, as well as how sleep maintains and restores normal human functions.

After completing a master's degree in biomedical engineering at the Massachusetts Institute of Technology, Krystal earned his medical degree at Duke University School of Medicine. He then completed a residency in psychiatry at Duke, followed by fellowships in sleep medicine and clinical neurophysiology, which studies the nervous system through recording the body's electrical activity. In addition to holding various leadership positions, he served as a faculty member and physician at Duke University Medical Center for more than two decades before joining UCSF in 2016.

Krystal is president of the Sleep Research Society and a member of the American Academy of Sleep Medicine, American Psychiatric Association and American College of Neuropsychopharmacology. He is also on the examination committee of the American Board of Sleep Medicines, which allows medical professionals to pursue certification in sleep medicine.


Neuro/Psych Sleep Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2273
Fax: (415) 353-2898

Hours: Monday to Friday
8:30 a.m. – 5 p.m.

Academic Title


More about Andrew Krystal


MIT, MS, Biomedical Engineering 1983
Duke University School of Medicine 1987


Duke University School of Medicine, Psychiatry 1991


Duke University School of Medicine, Sleep Medicine and Clinical Neurophysiology 1993

Selected Research and Publications

  1. Bei B, Asarnow LD, Krystal A, Edinger JD, Buysse DJ, Manber R. Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories. J Consult Clin Psychol. 2018 Mar; 86(3):282-293.
  2. McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal AD, Sampson SM, Morales O, Nelson BG, Latoussakis V, George MS, Lisanby SH. Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression. J Clin Psychiatry. 2018 Jan/Feb; 79(1).
  3. McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal A, Sampson S, Morales O, Nelson BG, George MS, Lisanby SH. Dr McClintock and Colleagues Reply. J Clin Psychiatry. 2018 Jan/Feb; 79(1).
  4. Rumble ME, Dickson D, McCall WV, Krystal AD, Case D, Rosenquist PB, Benca RM. The relationship of person-specific eveningness chronotype, greater seasonality, and less rhythmicity to suicidal behavior: A literature review. J Affect Disord. 2018 Feb; 227:721-730.
  5. Goucher Miranda H, Krystal AD, Fierro MA. Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation? Anesthesiology. 2017 08; 127(2):397-398.
  6. Connor KM, Ceesay P, Hutzelmann J, Snavely D, Krystal AD, Trivedi MH, Thase M, Lines C, Herring WJ, Michelson D. Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. Int J Neuropsychopharmacol. 2017 Aug 01; 20(8):613-618.
  7. Carney CE, Edinger JD, Kuchibhatla M, Lachowski AM, Bogouslavsky O, Krystal AD, Shapiro CM. Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial. Sleep. 2017 04 01; 40(4).
  8. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials. Am J Geriatr Psychiatry. 2017 Jul; 25(7):791-802.
  9. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data. Psychopharmacology (Berl). 2017 Jun; 234(11):1703-1711.
  10. Nadler JW, Evans JL, Fang E, Preud'Homme XA, Daughtry RL, Chapman JB, Bolognesi MP, Attarian DE, Wellman SS, Krystal AD. A randomised trial of peri-operative positive airway pressure for postoperative delirium in patients at risk for obstructive sleep apnoea after regional anaesthesia with sedation or general anaesthesia for joint arthroplasty. Anaesthesia. 2017 Jun; 72(6):729-736.
  11. Edinger JD, Manber R, Buysse DJ, Krystal AD, Thase ME, Gehrman P, Fairholme CP, Luther J, Wisniewski S. Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study. J Clin Sleep Med. 2017 Feb 15; 13(2):205-213.
  12. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017 Feb 15; 13(2):307-349.
  13. Samson DR, Manus MB, Krystal AD, Fakir E, Yu JJ, Nunn CL. Segmented sleep in a nonelectric, small-scale agricultural society in Madagascar. Am J Hum Biol. 2017 Jul 08; 29(4).
  14. Krystal AD, Preud'homme XA. Double-Blind, Placebo-Controlled, Crossover Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia. Sleep. 2017 01 01; 40(1).
  15. Bathgate CJ, Edinger JD, Krystal AD. Insomnia Patients With Objective Short Sleep Duration Have a Blunted Response to Cognitive Behavioral Therapy for Insomnia. Sleep. 2017 01 01; 40(1).
  16. Krystal AD, Prather AA. Should Internet Cognitive Behavioral Therapy for Insomnia Be the Primary Treatment Option for Insomnia?: Toward Getting More SHUTi. JAMA Psychiatry. 2017 Jan 01; 74(1):15-16.
  17. Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, Vitiello MV. National Sleep Foundation's sleep quality recommendations: first report. Sleep Health. 2017 Feb; 3(1):6-19.
  18. Ptáoek LJ, Fu YH, Krystal AD. Sleep and Mood: Chicken or Egg? Biol Psychiatry. 2016 12 01; 80(11):810-811.
  19. Lunsford-Avery JR, Krystal AD, Kollins SH. Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research. Clin Psychol Rev. 2016 Oct 23; 50:159-174.
  20. Manber R, Buysse DJ, Edinger J, Krystal A, Luther JF, Wisniewski SR, Trockel M, Kraemer HC, Thase ME. Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial. J Clin Psychiatry. 2016 Oct; 77(10):e1316-e1323.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.