Benjamin Cheyette, MD


Dr. Benjamin N.R. Cheyette is an attending psychiatrist in the adult Psychiatry Clinic at Langley Porter Psychiatric Hospital and Clinics. He has supervised residents and medical students in the anxiety disorders specialty clinic, the medication management clinic, the psychotherapy clinic and the Psychiatry Consultation-Liaison service to the hospital at Parnassus.

Cheyette is a graduate of the UCLA School of Medicine and the Psychiatry Residency Training Program at the University of Washington. He joined the UCSF faculty in 2002. He also has a Ph.D. in Molecular Biology from UCLA, and his other roles at UCSF include directing an NIH-funded laboratory that investigates biological origins of major mental illnesses, as well as serving as the co-director of the Pathway to Discovery in Molecular Medicine.


Psychiatry Clinic
401 Parnassus Ave.
San Francisco, CA 94143
Phone: (415) 476-7500
Fax: (415) 502-6361

Board Certification

Psychiatry, American Board of Psychiatry and Neurology

Academic Title


More about Benjamin Cheyette


University of California Los Angeles School of Medicine 1994


University of Washington Medical Center 1999

Selected Research and Publications

  1. Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR. Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation. Cereb Cortex. 2018 Feb 21.
  2. Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR. Sestd1 encodes a developmentally dynamic synapse protein that complexes with BCR Rac1-GAP to regulate forebrain dendrite, spine and synapse formation. Cerebral Cortex. 2017.
  3. Mulligan KA, Cheyette BN. Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry. Mol Neuropsychiatry. 2017 Feb; 2(4):219-246.
  4. Martin PM, Stanley RE, Ross AP, Freitas AE, Moyer CE, Brumback AC, Iafrati J, Stapornwongkul KS, Dominguez S, Kivimäe S, Mulligan KA, Pirooznia M, McCombie WR, Potash JB, Zandi PP, Purcell SM, Sanders SJ, Zuo Y, Sohal VS, Cheyette BNR. DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/ß-catenin signaling. Mol Psychiatry. 2018 Feb; 23(2):467-475.
  5. Cheyette BN, Cheyette SN. Acute exacerbation of irritable bowel syndrome prevented by prn oral triptan. Clin J Gastroenterology. 2016; 6(9):375-378; PMID: 27699640 .
  6. Mulligan K, Cheyette BN. "The Wnt Signaling Pathways." In R. P. Erickson & A. J. Wynshaw-Boris (Eds.) Inborn Errors of Development, 3rd edition. 2016; 323-329.
  7. Okerlund ND, Stanley RE, Cheyette BN. The Planar Cell Polarity Transmembrane Protein Vangl2 Promotes Dendrite, Spine and Glutamatergic Synapse Formation in the Mammalian Forebrain. Mol Neuropsychiatry. 2016 Jul; 2(2):107-14.
  8. Cheyette SR, Johnson P, Cheyette BN. ADHD & The Focused Mind. 2016; 260 pages. Print..
  9. Yang X, Fisher DA, Cheyette BN. SEC14 and Spectrin Domains 1 (Sestd1), Dishevelled 2 (Dvl2) and Dapper Antagonist of Catenin-1 (Dact1) co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian development. Commun Integr Biol. 2013 Nov 01; 6(6):e26834.
  10. Arguello A, Cheyette BN. Dapper Antagonist of Catenin-1 (Dact1) contributes to dendrite arborization in forebrain cortical interneurons. Commun Integr Biol. 2013 Nov 01; 6(6):e26656.
  11. Martin PM, Yang X, Robin N, Lam E, Rabinowitz JS, Erdman CA, Quinn J, Weiss LA, Hamilton SP, Kwok PY, Moon RT, Cheyette BN. A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation. Transl Psychiatry. 2013 Sep 03; 3:e301.
  12. Arguello A, Yang X, Vogt D, Stanco A, Rubenstein JL, Cheyette BN. Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons. PLoS One. 2013; 8(6):e67679.
  13. Yang X, Cheyette BN. SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) four-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic development in mice. J Biol Chem. 2013 Jul 12; 288(28):20111-20.
  14. Mulligan KA, Cheyette BN. Wnt signaling in vertebrate neural development and function. J Neuroimmune Pharmacol. 2012 Dec; 7(4):774-87.
  15. Kivimäe S, Martin PM, Kapfhamer D, Ruan Y, Heberlein U, Rubenstein JL, Cheyette BN. Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1. Transl Psychiatry. 2011 Sep 27; 1:e43.
  16. Kivimäe S, Yang XY, Cheyette BN. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. BMC Biochem. 2011 Jun 30; 12:33.
  17. Okerlund ND, Cheyette BN. Synaptic Wnt signaling-a contributor to major psychiatric disorders? J Neurodev Disord. 2011 Jun; 3(2):162-74.
  18. Okerlund ND, Kivimäe S, Tong CK, Peng IF, Ullian EM, Cheyette BN. Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J Neurosci. 2010 Mar 24; 30(12):4362-8.
  19. Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K. Dact1-3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010 Feb-Mar; 10(2-3):140-3.
  20. Suriben R, Kivimäe S, Fisher DA, Moon RT, Cheyette BN. Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009 Sep; 41(9):977-85.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.