Bryce Mendelsohn, MD, PhD

Medical geneticist

Dr. Bryce Mendelsohn is a clinical geneticist who provides evaluations and testing for pediatric and adult patients with suspected genetic conditions. He sees patients at the Medical Genetics and Genomics Clinic at Mission Bay, UCSF Medical Center at Parnassus and UCSF Benioff Children's Hospital Oakland.

Mendelsohn's areas of research include metabolic and mitochondrial diseases, which result from problems with cellular energy production that can eventually lead to complex dysfunction of multiple different organ systems. He is also interested in understanding how new genetic technologies impact health and costs in medicine, particularly for healthy people.

Mendelsohn received his medical degree from the Washington University School of Medicine in St. Louis, where he also completed a doctoral degree in molecular genetics and genomics. He completed post-doctoral work at the University of California, San Diego, and Gladstone Institutes in San Francisco. He also completed residencies in pediatrics and medical genetics at UCSF.

Mendelsohn is the author of "Precision Medicine: A Guide to Genomics in Clinical Practice," published by McGraw-Hill in 2016.


Biochemical Genetic Medicine Clinic
1825 Fourth St., Sixth Floor
San Francisco, CA 94158
Phone: (415) 476-9997
Fax: (415) 476-9976

Hours: Monday to Friday
8 a.m. – 5 p.m.

Lysosomal Disease Center
1825 Fourth St., Sixth Floor
San Francisco, CA 94158
Phone: (866) 476-9997
Fax: (415) 476-9976

Hours: Monday to Friday
9 a.m. – 5 p.m.

Medical Genetics and Genomics Clinic
1825 Fourth Street, Sixth Floor
San Francisco, CA 94158
Phone: (415) 476-2757
Fax: (415) 476-9305

Hours: Mondays, Tuesdays and Wednesdays

Preventive Genomics Clinic
2330 Post St., Suite 219
San Francisco, CA 94115
Phone: (415) 476-2757
Fax: (415) 476-9305
Email: Bryce.M

Academic Title

Assistant Professor

More about Bryce Mendelsohn


Washington University School of Medicine 2010


UCSF Medical Center 2016

Selected Research and Publications

  1. Hirabayashi KE, Moore AT, Mendelsohn BA, Taft RJ, Chawla A, Perry D, Henry D, Slavotinek A. Congenital sodium diarrhea and chorioretinal coloboma with optic disc coloboma in a patient with biallelic SPINT2 mutations, including p.(Tyr163Cys). Am J Med Genet A. 2018 Apr; 176(4):997-1000.
  2. Slavotinek A, Risolino M, Losa M, Cho MT, Monaghan KG, Schneidman-Duhovny D, Parisotto S, Herkert JC, Stegmann APA, Miller K, Shur N, Chui J, Muller E, DeBrosse S, Szot JO, Chapman G, Pachter NS, Winlaw DS, Mendelsohn BA, Dalton J, Sarafoglou K, Karachunski PI, Lewis JM, Pedro H, Dunwoodie SL, Selleri L, Shieh J. De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects. Hum Mol Genet. 2017 Dec 15; 26(24):4849-4860.
  3. Eppley S, Hopkin RJ, Mendelsohn B, Slavotinek AM. Clinical Report: Warsaw Breakage Syndrome with small radii and fibulae. Am J Med Genet A. 2017 Nov; 173(11):3075-3081.
  4. Punwani D, Zhang Y, Yu J, Cowan MJ, Rana S, Kwan A, Adhikari AN, Lizama CO, Mendelsohn BA, Fahl SP, Chellappan A, Srinivasan R, Brenner SE, Wiest DL, Puck JM. Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B. N Engl J Med. 2016 12 01; 375(22):2165-2176.
  5. Petty EL, Lafon A, Tomlinson SL, Mendelsohn BA, Pillus L. Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae. Genetics. 2016 08; 203(4):1693-707.
  6. Scott AI, Mendelsohn BA, Le A, Cowan TM. The antibiotic cefepime interferes with amino acid analysis by ion-exchange chromatography. Clin Chim Acta. 2016 May 01; 456:149-150.
  7. Pathak D, Shields LY, Mendelsohn BA, Haddad D, Lin W, Gerencser AA, Kim H, Brand MD, Edwards RH, Nakamura K. The role of mitochondrially derived ATP in synaptic vesicle recycling. J Biol Chem. 2015 Sep 11; 290(37):22325-36.
  8. Slavotinek AM, Garcia ST, Chandratillake G, Bardakjian T, Ullah E, Wu D, Umeda K, Lao R, Tang PL, Wan E, Madireddy L, Lyalina S, Mendelsohn BA, Dugan S, Tirch J, Tischler R, Harris J, Clark MJ, Chervitz S, Patwardhan A, West JM, Ursell P, de Alba Campomanes A, Schneider A, Kwok PY, Baranzini S, Chen RO. Exome sequencing in 32 patients with anophthalmia/microphthalmia and developmental eye defects. Clin Genet. 2015 Nov; 88(5):468-73.
  9. Mendelsohn BA, Pronold M, Long R, Smaoui N, Slavotinek AM. Advanced bone age in a girl with Wiedemann-Steiner syndrome and an exonic deletion in KMT2A (MLL). Am J Med Genet A. 2014 Aug; 164A(8):2079-83.
  10. Mendelsohn BA, Jeng LL, Oberoi S, Klein OD. Dental findings in 14q terminal deletion syndrome. Clin Dysmorphol. 2014 Apr; 23(2):60-2.
  11. Mendelsohn BA, Mehta N, Hameed B, Pekmezci M, Packman S, Ralph J. Adult-Onset Fatal Neurohepatopathy in a Woman Caused by MPV17 Mutation. JIMD Rep. 2014; 13:37-41.
  12. Mendelsohn BA. A piece of my mind. What is natural? JAMA. 2013 May 01; 309(17):1783-4.
  13. Mendelsohn BA, Malone JP, Townsend RR, Gitlin JD. Proteomic analysis of anoxia tolerance in the developing zebrafish embryo. Comp Biochem Physiol Part D Genomics Proteomics. 2009 Mar; 4(1):21-31.
  14. Mendelsohn BA, Gitlin JD. Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo. Dev Dyn. 2008 Jul; 237(7):1789-98.
  15. Mendelsohn BA, Kassebaum BL, Gitlin JD. The zebrafish embryo as a dynamic model of anoxia tolerance. Dev Dyn. 2008 Jul; 237(7):1780-8.
  16. Madsen EC, Morcos PA, Mendelsohn BA, Gitlin JD. In vivo correction of a Menkes disease model using antisense oligonucleotides. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3909-14.
  17. Gansner JM, Mendelsohn BA, Hultman KA, Johnson SL, Gitlin JD. Essential role of lysyl oxidases in notochord development. Dev Biol. 2007 Jul 15; 307(2):202-13.
  18. Mendelsohn BA, Yin C, Johnson SL, Wilm TP, Solnica-Krezel L, Gitlin JD. Atp7a determines a hierarchy of copper metabolism essential for notochord development. Cell Metab. 2006 Aug; 4(2):155-62.
  19. Mendelsohn BA, Li AM, Vargas CA, Riehman K, Watson A, Fridovich-Keil JL. Genetic and biochemical interactions between SCP160 and EAP1 in yeast. Nucleic Acids Res. 2003 Oct 15; 31(20):5838-47.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.