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Signs & Symptoms Endocrinology

Signs and Symptoms

In acromegaly, elevated growth hormone causes an abnormal increase in shoe and ring size, enlargement of the lower jaw bone and separation of teeth, and enlargement of the nose. These developments usually occur gradually and may not be noticed for years.

Other tissue in the body also can become enlarged, causing symptoms such as:

  • Carpal tunnel syndrome
  • Deepening of the voice
  • Diabetes
  • Excessive sweating and changes in body odor
  • Increased risk of colon polyps
  • Joint pain and stiffness
  • Sleep apnea and snoring due to obstruction of the airway
  • Thickening of the heart muscles

UCSF Health medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your provider.