Daniel Lowenstein, MD

Executive Vice Chancellor and Provost

Dr. Daniel H. Lowenstein, executive vice chancellor and provost of UCSF, is focused on expanding epilepsy care and services for UCSF Medical Center patients. An internationally known epileptologist, he was recently appointed director of the Epilepsy Center after serving as Dean of Medical Education at Harvard Medical School, of which he is a graduate. He also is currently president-elect of the American Epilepsy Society. Lowenstein spent many years at UCSF as professor of neurology and director of the Epilepsy Research Laboratory in the School of Medicine. A prolific writer and scholar, he has received virtually every teaching award given by UCSF's School of Medicine. His interests include the molecular and cellular changes in neural networks following seizure activity and injury, the genetic basis of epilepsy, and therapy for abnormally prolonged seizures known as status epilepticus.

Conditions & Treatments

More about Daniel Lowenstein

Education

Harvard University 1983

Residencies

UCSF, Neurology 1987

Selected Research and Publications

  1. Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia. 2018 Jan; 59(1):37-66.
  2. Zhu X, Padmanabhan R, Copeland B, Bridgers J, Ren Z, Kamalakaran S, O'Driscoll-Collins A, Berkovic SF, Scheffer IE, Poduri A, Mei D, Guerrini R, Lowenstein DH, Allen AS, Heinzen EL, Goldstein DB. A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations. PLoS Genet. 2017 Nov; 13(11):e1007104.
  3. Myers CT, Stong N, Mountier EI, Helbig KL, Freytag S, Sullivan JE, Ben Zeev B, Nissenkorn A, Tzadok M, Heimer G, Shinde DN, Rezazadeh A, Regan BM, Oliver KL, Ernst ME, Lippa NC, Mulhern MS, Ren Z, Poduri A, Andrade DM, Bird LM, Bahlo M, Berkovic SF, Lowenstein DH, Scheffer IE, Sadleir LG, Goldstein DB, Mefford HC, Heinzen EL. De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures. Am J Hum Genet. 2017 Oct 05; 101(4):516-524.
  4. Goldenholz DM, Goldenholz SR, Moss R, French J, Lowenstein D, Kuzniecky R, Haut S, Cristofaro S, Detyniecki K, Hixson J, Karoly P, Cook M, Strashny A, Theodore WH, Pieper C. Does accounting for seizure frequency variability increase clinical trial power? Epilepsy Res. 2017 Nov; 137:145-151.
  5. Bramswig NC, Lüdecke HJ, Hamdan FF, Altmüller J, Beleggia F, Elcioglu NH, Freyer C, Gerkes EH, Demirkol YK, Knupp KG, Kuechler A, Li Y, Lowenstein DH, Michaud JL, Park K, Stegmann APA, Veenstra-Knol HE, Wieland T, Wollnik B, Engels H, Strom TM, Kleefstra T, Wieczorek D. Heterozygous HNRNPU variants cause early onset epilepsy and severe intellectual disability. Hum Genet. 2017 07; 136(7):821-834.
  6. Kleen JK, Lowenstein DH. Progress in Epilepsy: Latest Waves of Discovery. JAMA Neurol. 2017 Feb 01; 74(2):139-140.
  7. Feldman WB, Kim AS, Josephson SA, Lowenstein DH, Chiong W. Effect of waivers of consent on recruitment in acute stroke trials: A systematic review. Neurology. 2016 04 19; 86(16):1543-51.
  8. Robbins NM, Larimer P, Bourgeois JA, Lowenstein DH. Number of patient-reported allergies helps distinguish epilepsy from psychogenic nonepileptic seizures. Epilepsy Behav. 2016 Feb; 55:174-7.
  9. Glauser T, Shinnar S, Gloss D, Alldredge B, Arya R, Bainbridge J, Bare M, Bleck T, Dodson WE, Garrity L, Jagoda A, Lowenstein D, Pellock J, Riviello J, Sloan E, Treiman DM. Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr. 2016 Jan-Feb; 16(1):48-61.
  10. Tan NC, Lowenstein DH. Improving your genetic literacy in epilepsy-A new series. Epilepsia. 2015 Nov; 56(11):1696-9.
  11. Lowenstein DH. Decade in review-epilepsy: edging toward breakthroughs in epilepsy diagnostics and care. Nat Rev Neurol. 2015 11; 11(11):616-7.
  12. Trinka E, Cock H, Hesdorffer D, Rossetti AO, Scheffer IE, Shinnar S, Shorvon S, Lowenstein DH. A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015 Oct; 56(10):1515-23.
  13. Rao VR, Lowenstein DH. Epilepsy. Curr Biol. 2015 Aug 31; 25(17):R742-6.
  14. Betjemann JP, Josephson SA, Lowenstein DH, Burke JF. Trends in Status Epilepticus-Related Hospitalizations and Mortality: Redefined in US Practice Over Time. JAMA Neurol. 2015 Jun; 72(6):650-5.
  15. Betjemann JP, Lowenstein DH. Status epilepticus in adults. Lancet Neurol. 2015 Jun; 14(6):615-24.
  16. Haenisch S, Zhao Y, Chhibber A, Kaiboriboon K, Do LV, Vogelgesang S, Barbaro NM, Alldredge BK, Lowenstein DH, Cascorbi I, Kroetz DL. SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients. Neurobiol Dis. 2015 May; 77:127-40.
  17. Welch RD, Nicholas K, Durkalski-Mauldin VL, Lowenstein DH, Conwit R, Mahajan PV, Lewandowski C, Silbergleit R. Intramuscular midazolam versus intravenous lorazepam for the prehospital treatment of status epilepticus in the pediatric population. Epilepsia. 2015 Feb; 56(2):254-62.
  18. EuroEPINOMICS-RES Consortium; Epilepsy Phenome/Genome Project; Epi4K Consortium. De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies. Am J Hum Genet. 2014; 4(95):360-70.
  19. Lowenstein DH, Walker M, Waterhouse E. Status epilepticus in the setting of acute encephalitis. Epilepsy Curr. 2014 Jan; 14(1 Suppl):43-9.
  20. Hegde M, Lowenstein DH. The search for circulating epilepsy biomarkers. Biomark Med. 2014; 8(3):413-27.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.