David Rowitch, MD, PhD

Chief of Neonatology

Dr. David Rowitch is chief of Neonatology and professor of pediatrics and neurosurgery at UCSF. In addition to caring for patients, he leads a laboratory that is investigating genetic factors that determine cellular development in the brain and its response to injury. Rowitch is also interested in neurological problems and brain cancer in premature infants.

Rowitch earned a medical degree at the University of California, Los Angeles and a doctorate in biochemistry at the University of Cambridge in England. He completed an internship and residency in pediatrics and a fellowship in newborn medicine at Children's Hospital in Boston. Rowitch participated in a postdoctoral fellowship at Harvard College in Cambridge. His work in neurobiology has earned him numerous awards, including the National Institute of Health Clinical Investigator Award, Kimmel Foundation Scholar Award and the James S. McDonnell Foundation Research Award. In 2008, Rowitch was appointed a Howard Hughes Medical Institute investigator.

Academic Title

Professor

More about David Rowitch

Education

University of Cambridge, U.K., Biochemistry 1988
UCLA School of Medicine 1989

Residencies

Children's Hospital, Boston, MA, Pediatrics 1992

Fellowships

Children's Hospital, Boston, MA, Neonatology 1995

Selected Research and Publications

  1. Nguyen V, Sabeur K, Maltepe E, Ameri K, Bayraktar O, Rowitch DH. Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury. Cerebellum. 2018 Apr; 17(2):213-227.
  2. Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH. Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron. 2018 Mar 28.
  3. Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM. Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Stem Cell Reports. 2017 Dec 12; 9(6):1745-1753.
  4. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7.
  5. Pla R, Stanco A, Howard MA, Rubin AN, Vogt D, Mortimer N, Cobos I, Potter GB, Lindtner S, Price JD, Nord AS, Visel A, Schreiner CE, Baraban SC, Rowitch DH, Rubenstein JLR. Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis. Cereb Cortex. 2017 Sep 28; 1-19.
  6. Shiow LR, Favrais G, Schirmer L, Schang AL, Cipriani S, Andres C, Wright JN, Nobuta H, Fleiss B, Gressens P, Rowitch DH. Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury. Glia. 2017 Dec; 65(12):2024-2037.
  7. Smith GC, Rowitch D, Mol BW. The role of prenatal steroids at 34-36 weeks of gestation. Arch Dis Child Fetal Neonatal Ed. 2017 Jul; 102(4):F284-F285.
  8. Sabo JK, Heine V, Silbereis JC, Schirmer L, Levison SW, Rowitch DH. Olig1 is required for noggin-induced neonatal myelin repair. Ann Neurol. 2017 Apr; 81(4):560-571.
  9. Zhou J, Tien AC, Alberta JA, Ficarro SB, Griveau A, Sun Y, Deshpande JS, Card JD, Morgan-Smith M, Michowski W, Hashizume R, James CD, Ligon KL, Snider WD, Sicinski P, Marto JA, Rowitch DH, Stiles CD. A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2. Cell Rep. 2017 03 28; 18(13):3167-3177.
  10. Dawes WJ, Zhang X, Fancy SPJ, Rowitch D, Marino S. Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone. Dev Neurosci. 2016; 38(6):430-444.
  11. Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017 01 26; 541(7638):481-487.
  12. Jablonska B, Gierdalski M, Chew LJ, Hawley T, Catron M, Lichauco A, Cabrera-Luque J, Yuen T, Rowitch D, Gallo V. Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. Nat Commun. 2016 Dec 19; 7:13866.
  13. Ben Haim L, Rowitch DH. Functional diversity of astrocytes in neural circuit regulation. Nat Rev Neurosci. 2017 01; 18(1):31-41.
  14. Osorio MJ, Rowitch DH, Tesar P, Wernig M, Windrem MS, Goldman SA. Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease. Stem Cells. 2017 02; 35(2):311-315.
  15. Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A. Extensive migration of young neurons into the infant human frontal lobe. Science. 2016 Oct 07; 354(6308).
  16. Kupp R, Shtayer L, Tien AC, Szeto E, Sanai N, Rowitch DH, Mehta S. Lineage-Restricted OLIG2-RTK Signaling Governs the Molecular Subtype of Glioma Stem-like Cells. Cell Rep. 2016 09 13; 16(11):2838-2845.
  17. Glass HC, Rowitch DH. The Role of the Neurointensive Care Nursery for Neonatal Encephalopathy. Clin Perinatol. 2016 Sep; 43(3):547-57.
  18. Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 07 27; 36(30):7925-35.
  19. Christou H, Dizon ML, Farrow KN, Jadcherla SR, Leeman KT, Maheshwari A, Rubin LP, Stansfield BK, Rowitch DH. Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies. Pediatr Res. 2016 Nov; 80(5):635-640.
  20. Lindquist RA, Guinto CD, Rodas-Rodriguez JL, Fuentealba LC, Tate MC, Rowitch DH, Alvarez-Buylla A. Identification of proliferative progenitors associated with prominent postnatal growth of the pons. Nat Commun. 2016 May 18; 7:11628.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.