Dean Sheppard, MD


Dr. Dean Sheppard is a pulmonologist who treats patients with lung disease while in the hospital, particularly those with asthma, chronic obstructive pulmonary disease (COPD), interstitial lung diseases and pulmonary infections. In his research, he studies the molecular mechanisms underlying common lung diseases and the development of targeted therapies for pulmonary fibrosis, acute lung injury and asthma.

Sheppard earned a medical degree at State University of New York in Stony Brook. He completed a residency in internal medicine at the University of Washington, followed by a pulmonary fellowship at UCSF. He is the recipient of numerous awards, including the American Thoracic Society's Lifetime Scientific Achievement Award, and the American Thoracic Society's Amberson Lecturer, bestowed to an individual with a career of major contributions to pulmonary science or clinical practice. He is a member of the American Thoracic Society, American Society of Clinical Investigation and Association of American Physicians. Sheppard is the founding director of the UCSF Lung Biology Center and chief of Pulmonary, Critical Care, Allergy and Sleep Medicine at UCSF Medical Center. He is a professor of medicine at UCSF.

Academic Title


More about Dean Sheppard


State University of New York at Stony Brook School of Medicine 1975


University of Washington Medical Center 1978


UCSF Medical Center 1980

Selected Research and Publications

  1. Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K. Cell Division Cycle 7-Kinase is a negative regulator of cell-mediated collagen degradation. Am J Physiol Lung Cell Mol Physiol. 2018 May 24.
  2. Kim KK, Sheppard D, Chapman HA. TGF-▀1 Signaling and Tissue Fibrosis. Cold Spring Harb Perspect Biol. 2018 Apr 02; 10(4).
  3. Stockis J, LiÚnart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S. Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin aV▀8. Proc Natl Acad Sci U S A. 2017 Nov 21; 114(47):E10161-E10168.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.