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Geoffrey Manley, M.D., Ph.D.


Dr. Geoffrey T. Manley, a trauma neurosurgeon and an internationally recognized expert in neurotrauma, specializes in brain and spinal cord injury and neurocritical care. He is a leader in the rapidly growing field of advanced neuromonitoring and clinical informatics for critical care.

Manley is a graduate of the Medical Scientist Training Program at Cornell University Medical College, where he earned a medical degree and doctorate in neuroscience. He completed a residency in neurosurgery and a postdoctoral fellowship in molecular biophysics at UCSF. Manley is a member of the California Institute for Quantitative Biosciences and the UCSF Center for Clinical and Translational Informatics. He has published over 120 manuscripts that reflect a wide range of research interests from molecular aspects of brain injury to the clinical care of head trauma patients. He has helped to define new molecular mechanisms of injury to the nervous system that may lead to new treatments for these devastating injuries. His many honors include the General Motors Trauma Research Award and Trauma Research Award from the American College of Surgeons. He has served as a consultant for the Prehospital Guidelines Committee for the World Health Organization and on a number of committees for the National Institutes of Health. He is chief of Neurosurgery at San Francisco General Hospital and a professor of neurosurgery at UCSF.


Concussion and Brain Injury Program
1500 Owens St., Second Floor
San Francisco, CA 94158
Phone: (415) 353-1915
Fax: (415) 514-6075

Hours: Monday to Friday
8 a.m. – 5 p.m.

More about Geoffrey Manley


Cornell University Medical College 1995


UCSF Medical Center 2001

Selected Research and Publications

  1. Yue JK, Winkler EA, McAllister TW, Temkin N, Ferguson A, Lingsma HF, Yuh E, Tarapore PE, Sharma S, Puccio A, Wang K, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley GT. 178 COMT Val158Met is Associated With Domain-Specific Cognitive Impairment Following Mild Traumatic Brain Injury. Neurosurgery. 2015 Aug; 62 Suppl 1:225.
  2. Hawryluk GW, Phan N, Ferguson A, Morabito D, Derugin N, Stewart C, Knudson M, Manley GT, Rosenthal G. 179 Brain Tissue Oxygen Tension and Its Response to Physiological Manipulations Is Dependent on Distance From Injury Site in a Swine Model of Traumatic Brain Injury. Neurosurgery. 2015 Aug; 62 Suppl 1:225.
  3. Yao X, Smith AJ, Jin BJ, Zador Z, Manley GT, Verkman AS. Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice. Glia. 2015 Oct; 63(10):1860-9.
  4. Yue JK, Pronger AM, Ferguson AR, Temkin NR, Sharma S, Rosand J, Sorani MD, McAllister TW, Barber J, Winkler EA, Burchard EG, Hu D, Lingsma HF, Cooper SR, Puccio AM, Okonkwo DO, Diaz-Arrastia R, Manley GT. Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury. Neurogenetics. 2015 Jan 30.
  5. Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): A Prospective Longitudinal Observational Study. Neurosurgery. 2015 Jan; 76(1):67-80.
  6. Hawryluk GW, Manley GT. Classification of traumatic brain injury: past, present, and future. Handb Clin Neurol. 2015; 127:15-21.
  7. Sorani MD, Yue JK, Sharma S, Manley GT, Ferguson AR. Genetic data sharing and privacy. Neuroinformatics. 2015 Jan; 13(1):1-6.
  8. Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, Goldstein FC, Caveney AF, Howlett-Smith H, Bengelink EM, Manley GT, Merck LH, Janis LS, Barsan WG. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014 Dec 25; 371(26):2457-66.
  9. Lingsma HF, Yue JK, Maas AI, Steyerberg EW, Manley GT, Cooper SR, Dams-O'Connor K, Gordon WA, Menon DK, Mukherjee P, Okonkwo DO, Puccio AM, Schnyer DM, Valadka AB, Vassar MJ, Yuh EL. Outcome Prediction after Mild and Complicated Mild Traumatic Brain Injury: External Validation of Existing Models and Identification of New Predictors Using the TRACK-TBI Pilot Study. J Neurotrauma. 2015 Jan 15; 32(2):83-94.
  10. Rosenthal G, Ng I, Moscovici S, Lee KK, Lay T, Martin C, Manley GT. Polyetheretherketone implants for the repair of large cranial defects: a 3-center experience. Neurosurgery. 2014 Nov; 75(5):523-9; discussion 528-9.
  11. Yao X, Derugin N, Manley GT, Verkman AS. Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia. Neurosci Lett. 2015 Jan 1; 584:368-72.
  12. Yuh EL, Hawryluk GW, Manley GT. Imaging concussion: a review. Neurosurgery. 2014 Oct; 75 Suppl 4:S50-63.
  13. McMahon PJ, Panczykowski D, Yue JK, Puccio AM, Inoue T, Sorani MD, Lingsma H, Maas A, Valadka A, Yuh EL, Mukherjee P, Manley GT, Okonkwo DO. Measurement of the GFAP-BDP Biomarker for the Detection of Traumatic Brain Injury Compared to CT and MRI. J Neurotrauma. 2014 Sep 29.
  14. Yuh EL, Cooper SR, Mukherjee P, Yue JK, Lingsma HF, Gordon WA, Valadka AB, Okonkwo DO, Schnyer DM, Vassar MJ, Maas AI, Manley GT, Casey SS, Cheong M, Dams-O'Connor K, Hricik AJ, Inoue T, Menon DK, Morabito DJ, Pacheco JL, Puccio AM, Sinha TK. Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: a TRACK-TBI study. J Neurotrauma. 2014 Sep 1; 31(17):1457-77.
  15. Ratcliff JJ, Adeoye O, Lindsell CJ, Hart KW, Pancioli A, McMullan JT, Yue JK, Nishijima DK, Gordon WA, Valadka AB, Okonkwo DO, Lingsma HF, Maas AI, Manley GT. ED disposition of the Glasgow Coma Scale 13 to 15 traumatic brain injury patient: analysis of the Transforming Research and Clinical Knowledge in TBI study. Am J Emerg Med. 2014 Aug; 32(8):844-50.
  16. Moore M, Winkelman A, Kwong S, Segal SP, Manley GT, Shumway M. The emergency department social work intervention for mild traumatic brain injury (SWIFT-Acute): a pilot study. Brain Inj. 2014; 28(4):448-55.
  17. Kolias AG, Hutchinson PJ, Menon DK, Manley GT, Gallagher CN, Servadei F. Decompressive craniectomy for acute subdural hematomas. J Neurosurg. 2014 May; 120(5):1247-9; author reply 1249.
  18. Sivaganesan A, Manley GT, Huang MC. Informatics for neurocritical care: challenges and opportunities. Neurocrit Care. 2014 Feb; 20(1):132-41.
  19. Inoue T, Manley GT, Patel N, Whetstone WD. Medical and surgical management after spinal cord injury: vasopressor usage, early surgerys, and complications. J Neurotrauma. 2014 Feb 1; 31(3):284-91.
  20. McMahon P, Hricik A, Yue JK, Puccio AM, Inoue T, Lingsma HF, Beers SR, Gordon WA, Valadka AB, Manley GT, Okonkwo DO. Symptomatology and functional outcome in mild traumatic brain injury: results from the prospective TRACK-TBI study. J Neurotrauma. 2014 Jan 1; 31(1):26-33.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.