James Smith, MD, MS

Director, UCSF Male Reproductive Health

Dr. James Smith directs the team providing male fertility preservation counseling and treatment, and evaluates and treats men with general fertility problems, low testosterone, erectile dysfunction and Peyronie's disease. He specializes in the use of microsurgical vasovasostomy, vasoepididymostomy, sperm retrieval and varicocelectomy. In addition to serving as director of Male Reproductive Health, Smith is an associate professor of urology and of obstetrics, gynecology and reproductive sciences at the UCSF School of Medicine.

Smith's primary research focus seeks to improve understanding of clinical, translational and basic mechanisms of male reproductive biology. Smith is an active member of the American Urological Association, the American Society for Reproductive Medicine, the Society of Reproductive Surgeons, the Society for Male Reproduction and Urology, and the Sexual Medicine Society of North America.

Smith received his master's degree in health and medical science, and his medical degree, from the University of California's Joint Medical Program (UC Berkeley and UCSF). He did his general surgery and urology training at the University of Utah in Salt Lake City, returning to UCSF to complete a fellowship in andrology.

Clinics

Center for Reproductive Health at Mission Bay
499 Illinois St., Sixth Floor
San Francisco, CA 94158
Phone: (415) 353-7475
Fax: (415) 353-7744

Hours: Monday to Friday
8 a.m. – 4:45 p.m.
Saturday and Sunday apts. available for patients undergoing treatment

Center for Reproductive Health at Mount Zion
2356 Sutter St., Seventh Floor
San Francisco, CA 94115
Phone: (415) 353-7475
Fax: (415) 353-7744

Hours: Monday to Friday
8 a.m. – 4:45 p.m.
Saturday and Sunday apts. available for patients undergoing treatment

Fertility Preservation Program
499 Illinois St., Sixth Floor
San Francisco, CA 94158
Hotline: (415) 353-9115
Fax: (415) 353-7744

Hours: Monday to Friday
8 a.m. – 5 p.m.

Gastrointestinal Oncology Survivorship Program
1825 Fourth St., Fourth Floor
San Francisco, CA 94143
Phone: (415) 353-9888
Fax: (415) 353-9931

Male Reproductive Health Center
2356 Sutter St., Third Floor
San Francisco, CA 94115
Phone: (415) 353-3076
Fax: (415) 885-3663

Hours: Monday to Friday
8 a.m. – 5 p.m.

Urology Practice
400 Parnassus Ave., Sixth Floor, Suite A610
San Francisco, CA 94143
Phone: (415) 353-2200
Fax: (415) 353-2641

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

Board Certification

Urology, American Board of Urology

Academic Title

Associate Professor

More about James Smith

Education

UCSF School of Medicine 2002

Residencies

University of Utah, Surgery and Urology 2007

Fellowships

UCSF Medical Center, Male Reproductive Health 2009

Selected Research and Publications

  1. Salomo K, Smith JF, Feild TS, Samain MS, Bond L, Davidson C, Zimmers J, Neinhuis C, Wanke S. The Emergence of Earliest Angiosperms may be Earlier than Fossil Evidence Indicates. Syst Bot. 2017 Dec; 42(4):607-619.
  2. Gilbert K, Nangia AK, Dupree JM, Smith JF, Mehta A. Fertility preservation for men with testicular cancer: Is sperm cryopreservation cost effective in the era of assisted reproductive technology? Urol Oncol. 2018 Mar; 36(3):92.e1-92.e9.
  3. Hall J, Ralph EC, Shanker S, Wang H, Byrnes LJ, Horst R, Wong J, Brault A, Dumlao D, Smith JF, Dakin LA, Schmitt DC, Trujillo J, Vincent F, Griffor M, Aulabaugh AE. The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition. Protein Sci. 2017 Dec; 26(12):2367-2380.
  4. Ramstein JJ, Tsai KK, Smith JF. Tyrosine Kinase Inhibitors and Male Reproductive Health. Clin Pharmacol Ther. 2017 Nov; 102(5):754-756.
  5. Swallow JG, Kim JJ, Maloney JM, Chen D, Smith JF, Bishop SR, Tuller HL, Van Vliet KJ. Dynamic chemical expansion of thin-film non-stoichiometric oxides at extreme temperatures. Nat Mater. 2017 Jul; 16(7):749-754.
  6. Ho JR, Hoffman JR, Aghajanova L, Smith JF, Cardenas M, Herndon CN. Demographic analysis of a low resource, socioculturally diverse urban community presenting for infertility care in a United States public hospital. Contracept Reprod Med. 2017; 2:17.
  7. Smith JF. Maternal fetal medicine. Curr Opin Obstet Gynecol. 2017 Apr; 29(2):65.
  8. Reynolds NK, Smith ME, Tretter ED, Gause J, Heeney D, Cafaro MJ, Smith JF, Novak SJ, Bourland WA, White MM. Resolving relationships at the animal-fungal divergence: A molecular phylogenetic study of the protist trichomycetes (Ichthyosporea, Eccrinida). Mol Phylogenet Evol. 2017 04; 109:447-464.
  9. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 Feb; 13(2):e1006163.
  10. Selvaraj V, Hour S, Gunasekar P, Gray C, Smith JF. Escitalopram-Induced Amenorrhea and False Positive Urine Pregnancy Test. Korean J Fam Med. 2017 Jan; 38(1):40-42.
  11. Hussein AA, Yango P, Ezz Y, Smith JF, Tran ND. Fertility preservation options for prepubertal boys facing gonadotoxic therapies. Minerva Ginecol. 2016 Dec; 68(6):668-74.
  12. Smith JF, Clark JL, Amaya-Márquez M, Marín-Gómez OH. Resolving incongruence: Species of hybrid origin in Columnea (Gesneriaceae). Mol Phylogenet Evol. 2017 01; 106:228-240.
  13. Winkelman WD, Katz PP, Smith JF, Rowen TS. The Sexual Impact of Infertility Among Women Seeking Fertility Care. Sex Med. 2016 Sep; 4(3):e190-7.
  14. Mehta A, Nangia AK, Dupree JM, Smith JF. Limitations and barriers in access to care for male factor infertility. Fertil Steril. 2016 05; 105(5):1128-1137.
  15. Moline HR, Smith JF. The continuing threat of syphilis in pregnancy. Curr Opin Obstet Gynecol. 2016 Apr; 28(2):101-4.
  16. Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science. 2016 Apr 29; 352(6285):555-9.
  17. Smith JF, Tran ND. Freezing and thawing testicular cells may not affect growth of cultured testicular cells. Fertil Steril. 2015 Nov; 104(5):1129.
  18. Singer ST, Killilea D, Suh JH, Wang ZJ, Yuan Q, Ivani K, Evans P, Vichinsky E, Fischer R, Smith JF. Fertility in transfusion-dependent thalassemia men: effects of iron burden on the reproductive axis. Am J Hematol. 2015 Sep; 90(9):E190-2.
  19. Hussein AA, Tran ND, Smith JF. Fertility preservation for boys and adolescents facing sterilizing medical therapy. Transl Androl Urol. 2014 Dec; 3(4):382-90.
  20. Yango P, Altman E, Smith JF, Klatsky PC, Tran ND. Optimizing cryopreservation of human spermatogonial stem cells: comparing the effectiveness of testicular tissue and single cell suspension cryopreservation. Fertil Steril. 2014 Nov; 102(5):1491-1498.e1.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.