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Jim Sonner, M.D.



Harvard School of Medicine 1988

Selected Research and Publications

  1. Sonner JM, Cantor RS. Molecular mechanisms of drug action: an emerging view. Annu Rev Biophys. 2013; 42:143-67.
  2. Hsu TT, Leiske DL, Rosenfeld L, Sonner JM, Fuller GG. 3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness. Langmuir. 2013 Feb 12; 29(6):1948-55.
  3. Rau V, Oh I, Liao M, Bodarky C, Fanselow MS, Homanics GE, Sonner JM, Eger EI. Gamma-aminobutyric acid type A receptor 3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg. 2011 Sep; 113(3):500-4.
  4. Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ. Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12143-8.
  5. Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, Changeux JP, Sonner JM, Delarue M, Corringer PJ. X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature. 2011 Jan 20; 469(7330):428-31.
  6. Werner DF, Swihart A, Rau V, Jia F, Borghese CM, McCracken ML, Iyer S, Fanselow MS, Oh I, Sonner JM, Eger EI, Harrison NL, Harris RA, Homanics GE. Inhaled anesthetic responses of recombinant receptors and knockin mice harboring a2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane. J Pharmacol Exp Ther. 2011 Jan; 336(1):134-44.
  7. Speca DJ, Chihara D, Ashique AM, Bowers MS, Pierce-Shimomura JT, Lee J, Rabbee N, Speed TP, Gularte RJ, Chitwood J, Medrano JF, Liao M, Sonner JM, Eger EI, Peterson AS, McIntire SL. Conserved role of unc-79 in ethanol responses in lightweight mutant mice. PLoS Genet. 2010 Aug; 6(8).
  8. Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI, Fanselow MS, Homanics GE, Sonner JM. Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg. 2009 Dec; 109(6):1816-22.
  9. Weng Y, Yang L, Corringer PJ, Sonner JM. Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel. Anesth Analg. 2010 Jan 1; 110(1):59-63.
  10. Weng Y, Hsu TT, Zhao J, Nishimura S, Fuller GG, Sonner JM. Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine. Anesth Analg. 2009 May; 108(5):1538-45.
  11. Milutinovic PS, Zhao J, Sonner JM. Tolerance to isoflurane does not occur in developing Xenopus laevis tadpoles. Anesth Analg. 2009 Jan; 108(1):176-80.
  12. Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM. Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 2008 Sep; 107(3):832-48.
  13. Yang L, Sonner JM. Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia. Anesth Analg. 2008 Sep; 107(3):868-74.
  14. Sonner JM. A hypothesis on the origin and evolution of the response to inhaled anesthetics. Anesth Analg. 2008 Sep; 107(3):849-54.
  15. Hendrickx JF, Eger EI, Sonner JM, Shafer SL. Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility. Anesth Analg. 2008 Aug; 107(2):494-506.
  16. Eger EI, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM. Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats. Anesth Analg. 2008 Aug; 107(2):479-85.
  17. Shafer SL, Hendrickx JF, Flood P, Sonner J, Eger EI. Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms. Anesth Analg. 2008 Aug; 107(2):507-24.
  18. Yost CS, Oh I, Eger EI, Sonner JM. Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity. Behav Brain Res. 2008 Nov 21; 193(2):192-6.
  19. Zhao J, Zhang Y, Eger EI, Sonner J. Intrathecal glycine significantly decreases the minimum alveolar concentration of isoflurane in rats. Chin Med Sci J. 2008 Mar; 23(1):16-8.
  20. Yang L, Sonner JM. The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors. Anesth Analg. 2008 Mar; 106(3):838-45, table of contents.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.