John Kane, PhD, MD

Director of the adult Lipid Clinic

Dr. John Kane is the director of the adult Lipid Clinic. He earned his medical degree at the University of Oregon School of Medicine. He completed an internship and residency in internal medicine at Stanford and UCSF; and a fellowship in endocrinology at UCSF. His research in lipoprotein metabolism, the management of disorders of lipoproteins, and the genetic basis of heart disease and stroke is known worldwide through his publications in refereed journals and book chapters. Kane is professor of medicine and professor of biochemistry and biophysics, and is an associate director of the Cardiovascular Research Institute at UCSF. He was an Established Investigator and is a fellow of the American Heart Association. He is a recent recipient of an Outstanding Achievement Award in the Genetics of Lipoprotein Metabolism and Atherosclerosis from the International Atherosclerosis Society. He is a diplomate of the American Board of Clinical Lipidology.


Endocrinology Clinic at Parnassus
400 Parnassus Ave., Suite A-550
San Francisco, CA 94143
Phone: (415) 353–2350
Fax: (415) 353–2337

Hours: Monday to Friday, 8:30 a.m. – 5 pm.

Lipid Practice
400 Parnassus Ave., Suite A-550
San Francisco, CA 94143
Phone: (415) 353–2350
Fax: (415) 353–2337

Hours: Monday to Friday, 8:30 a.m. – 5 p.m.

More about John Kane

Additional Languages



University of Oregon 1957


Stanford University Hospital and UCSF
Stanford University Hospitals


UCSF, Endocrinology

Selected Research and Publications

  1. Quinn AG, Schwemberger R, Stock EO, Movsesyan I, Axtell A, Chang S, Ishida BY, Malloy MJ, Kane JP, Pullinger CR. Moderate statin treatment reduces prebeta-1 high-density lipoprotein levels in dyslipidemic patients. J Clin Lipidol. 2017 Jul - Aug; 11(4):908-914.
  2. Hayne CK, Lafferty MJ, Eglinger BJ, Kane JP, Neher SB. Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake. Biochemistry. 2017 Jan 24; 56(3):525-533.
  3. Kane JP, Malloy MJ. Lipoproteins and amyloid vascular disease. Curr Opin Lipidol. 2016 Dec; 27(6):640-641.
  4. Versmissen J, Vongpromek R, Yahya R, van der Net JB, van Vark-van der Zee L, Blommesteijn-Touw J, Wattimena D, Rietveld T, Pullinger CR, Christoffersen C, Dahlbäck B, Kane JP, Mulder M, Sijbrands EJ. Familial hypercholesterolaemia: cholesterol efflux and coronary disease. Eur J Clin Invest. 2016 Jul; 46(7):643-50.
  5. Kane JP, Malloy MJ. In memoriam: Richard J. Havel (1925-2016). J Lipid Res. 2016 May 12.
  6. Kane JP. Infectious basophilia? Am J Hematol. 2016 Feb; 91(2):E8.
  7. Kane JP, Malloy MJ. Emerging molecular strategies for management of dyslipidemias. Curr Opin Lipidol. 2015 Dec; 26(6):601-2.
  8. Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ. Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. J Am Coll Cardiol. 2015 Nov 17; 66(20):2201-2210.
  9. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406.
  10. Pullinger CR, Stock EO, Movsesyan I, Malloy MJ, Frost PH, Tripuraneni R, Quinn AG, Ishida BY, Schaefer EJ, Asztalos BF, Kane JP. Identification and metabolic profiling of patients with lysosomal acid lipase deficiency. J Clin Lipidol. 2015 Sep-Oct; 9(5):716-26.e1.
  11. Kane JP, Malloy MJ, Pullinger CR. HDL cholesterol efflux capacity and cardiovascular events. N Engl J Med. 2015 May 07; 372(19):1871.
  12. Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet. 2015 Apr; 8(2):343-50.
  13. Malloy MJ, Kane JP. Congenital absence of apolipoprotein E and neurological function-reply. JAMA Neurol. 2014 Dec; 71(12):1579.
  14. Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol. 2014 Oct; 71(10):1228-36.
  15. Sharma V, Witkowski A, Witkowska HE, Dykstra A, Simonsen JB, Nelbach L, Beckstead JA, Pullinger CR, Kane JP, Malloy MJ, Watson G, Forte TM, Ryan RO. Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291). Arterioscler Thromb Vasc Biol. 2014 Oct; 34(10):2254-60.
  16. Valayannopoulos V, Malinova V, Honzík T, Balwani M, Breen C, Deegan PB, Enns GM, Jones SA, Kane JP, Stock EO, Tripuraneni R, Eckert S, Schneider E, Hamilton G, Middleton MS, Sirlin C, Kessler B, Bourdon C, Boyadjiev SA, Sharma R, Twelves C, Whitley CB, Quinn AG. Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency. J Hepatol. 2014 Nov; 61(5):1135-42.
  17. Arndt C, Leclercq I, Nazeyrollas P, Durlach A, Ducasse A, Movesayan I, Socquard E, Clavel C, Malloy MM, Pullinger CR, Kane JP, Durlach V. Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients. Diabetes Metab. 2014 Dec; 40(6):452-8.
  18. Rowland CM, Pullinger CR, Luke MM, Shiffman D, Green L, Movsesyan I, Devlin JJ, Malloy MJ, Kane JP, Undas A. Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties. Thromb Res. 2014 May; 133(5):863-7.
  19. Pullinger CR, Goldfine ID, Tanyolaç S, Movsesyan I, Faynboym M, Durlach V, Chiefari E, Foti DP, Frost PH, Malloy MJ, Brunetti A, Kane JP. Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population. Metab Syndr Relat Disord. 2014 Feb; 12(1):25-30.
  20. Kane JP, Malloy MJ. Needed: a better understanding of the antiatherogenic properties of HDL. Curr Opin Lipidol. 2013 Oct; 24(5):453-4.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.