Liviu Klein, MD, MS


Dr. Liviu Klein, a cardiologist at the UCSF Heart and Vascular Center, is director of the Mechanical Circulatory Support and Heart Failure Device Program. He specializes in treating patients with heart failure and arrhythmias, including patients before and after heart transplants. He also has expertise in cardiac resynchronization and mechanical therapies such as ventricular assist devices for heart failure. In his research, he studies the epidemiology of heart failure in women, including those at risk for sudden cardiac death. Together with colleagues in the department of Bioengineering and Therapeutic Sciences at UCSF, he is developing new technologies for monitoring and treating patients with cardiovascular disease (including heart failure), and for those who use ventricular assist devices.

Klein earned a medical degree at the Carol Davila School of Medicine in Bucharest, Romania, and earned a master's of science in clinical investigation at Northwestern University in Evanston, Ill. He completed a residency in internal medicine at the Advocate Illinois Masonic Medical Center in Chicago and a fellowship in cardiovascular epidemiology at Northwestern University's Feinberg School of Medicine. At Northwestern's McGaw Medical Center in Chicago, he completed fellowships in cardiovascular disease, advanced heart failure and transplantation, and clinical cardiac electrophysiology. Klein is a member of the American Heart Association, Heart Failure Society of America and International Society for Lung and Heart Transplant. He has published more than 60 peer-reviewed articles and books. At UCSF, he is an associate professor of clinical medicine.


Advanced Heart Failure Evaluation and Therapies Program
400 Parnassus Ave., Fifth Floor
San Francisco, CA 94143
Phone: (415) 353-4145
Fax: (415) 353-4166

Hours: Thursday 12:30 p.m. - 5 p.m.

Cardiovascular Care and Prevention Center at Mission Bay
535 Mission Bay Blvd. South
San Francisco, CA 94158
Phone: (415) 353-2873
Fax: (415) 353-2528

Hours: Monday to Friday
8 a.m. – 5 p.m.

Heart Transplant Program
400 Parnassus Ave., Fifth Floor
San Francisco, CA 94143
Phone: (415) 353-4145
Fax: (415) 353-4166

Hours: Thursday 12:30 p.m. - 5 p.m.

Mechanical Circulatory Support
400 Parnassus Ave., Fifth Floor
San Francisco, CA 94143
Phone: (415) 353-4145
Fax: (415) 353-4166

Hours: 8 a.m. – 5 p.m.

Conditions & Treatments

Board Certification

Advanced Heart Failure & Trans
Cardiovascular Disease

More about Liviu Klein


Universitatea De Medicina Si Farmacie, Bucharest Romania 1999


Advocate Illinois Masonic Medical Center, Chicago, Internal Medicine 2003


Northwestern University, Cardiovascular Epidemiology 2005
McGaw Medical Center, Northwestern University, Cardiovascular Disease 2007
McGaw Medical Center, Northwestern University, Advanced Heart Failure and Transplantation 2008
McGaw Medical Center, Northwestern University, Cardiac Electrophysiology 2009

Selected Research and Publications

  1. Pandey A, Omar W, Ayers C, LaMonte M, Klein L, Allen N, Kuller LH, Greenland P, Eaton C, Gottdiener JS, Lloyd-Jones D, Berry JD. Sex and Race Differences in Lifetime Risk of Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction. Circulation. 2018 Jan 19.
  2. Inan OT, Baran Pouyan M, Javaid AQ, Dowling S, Etemadi M, Dorier A, Heller JA, Bicen AO, Roy S, De Marco T, Klein L. Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients. Circ Heart Fail. 2018 Jan; 11(1):e004313.
  3. Klein L. (Re)Discovering the Neurohormonal and Hemodynamic Duality of Heart Failure. J Am Coll Cardiol. 2017 Oct 10; 70(15):1887-1889.
  4. Hall PS, Nah G, Howard BV, Lewis CE, Allison MA, Sarto GE, Waring ME, Jacobson LT, Manson JE, Klein L, Parikh NI. Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative. J Am Coll Cardiol. 2017 May 23; 69(20):2517-2526.
  5. Pandey A, LaMonte M, Klein L, Ayers C, Psaty BM, Eaton CB, Allen NB, de Lemos JA, Carnethon M, Greenland P, Berry JD. Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure. J Am Coll Cardiol. 2017 Mar 07; 69(9):1129-1142.
  6. Brondfield MN, Reid MJ, Rutishauser RL, Cope JR, Tang J, Ritter JM, Matanock A, Ali I, Doernberg SB, Hilts-Horeczko A, DeMarco T, Klein L, Babik JM. Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature. Transpl Infect Dis. 2017 Apr; 19(2).
  7. Cowie MR, Simon M, Klein L, Thokala P. The cost-effectiveness of real-time pulmonary artery pressure monitoring in heart failure patients: a European perspective. Eur J Heart Fail. 2017 May; 19(5):661-669.
  8. Eaton CB, Pettinger M, Rossouw J, Martin LW, Foraker R, Quddus A, Liu S, Wampler NS, Hank Wu WC, Manson JE, Margolis K, Johnson KC, Allison M, Corbie-Smith G, Rosamond W, Breathett K, Klein L. Risk Factors for Incident Hospitalized Heart Failure With Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women. Circ Heart Fail. 2016 Oct; 9(10).
  9. Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM. Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico. Int J Artif Organs. 2016 Oct 10; 39(8):421-430.
  10. Klein L. Treating Hemodynamic Congestion Is the Key to Prevent Heart Failure Hospitalizations. JACC Heart Fail. 2016 May; 4(5):345-7.
  11. Klein L, Greenberg BH, Konstam MA, Gregory D, Kociol RD, Johnson MR, de Marco T. Activities and Compensation of Advanced Heart Failure Specialists: Results of the Heart Failure Society of America (HFSA) Survey. J Card Fail. 2015 Nov; 21(11):924-9.
  12. Rogers SE, Klein L, Perissinotto CM. The importance of cognitive assessment before ventricular device placement: a teachable moment. JAMA Intern Med. 2015 Jun; 175(6):890.
  13. Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S. A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables. IEEE Trans Biomed Circuits Syst. 2016 Apr; 10(2):280-8.
  14. Donneyong MM, Hornung CA, Taylor KC, Baumgartner RN, Myers JA, Eaton CB, Gorodeski EZ, Klein L, Martin LW, Shikany JM, Song Y, Li W, Manson JE. Risk of heart failure among postmenopausal women: a secondary analysis of the randomized trial of vitamin D plus calcium of the women's health initiative. Circ Heart Fail. 2015 Jan; 8(1):49-56.
  15. Wiens AD, Etemadi M, Roy S, Klein L, Inan OT. Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography. IEEE J Biomed Health Inform. 2015 Jul; 19(4):1435-42.
  16. Klein L, Hsia H. Sudden cardiac death in heart failure. Cardiol Clin. 2014 Feb; 32(1):135-44, ix.
  17. Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT. Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5188-91.
  18. Wiens A, Etemadi M, Klein L, Roy S, Inan OT. Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5172-5.
  19. Sridharan L, Klein L. Prognostic factors in patients hospitalized for heart failure. Curr Heart Fail Rep. 2013 Dec; 10(4):380-6.
  20. Perez MV, Wang PJ, Larson JC, Soliman EZ, Limacher M, Rodriguez B, Klein L, Manson JE, Martin LW, Prineas R, Connelly S, Hlatky M, Wassertheil-Smoller S, Stefanick ML. Risk factors for atrial fibrillation and their population burden in postmenopausal women: the Women's Health Initiative Observational Study. Heart. 2013 Aug; 99(16):1173-8.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.