Alzheimer's Disease Symposium

May 20, 2005
News Office: John Watson (415) 502-6397

WHEN: Thursday, May 26, 8:30 a.m.-2 p.m., followed by Gladstone building tour

WHERE: J. David Gladstone Institutes, 1650 Owens St., San Francisco

WHAT: The Alzheimer's Association and the Gladstone Institute of Neurological Disease will host a research symposium involving some of the world's leading Alzheimer's disease researchers. Speakers are affiliated with Gladstone, University of California, San Francisco, the Buck Institute, University of California, Davis, and Stanford University.

The first Bay Area Alzheimer's Disease Research Symposium, taking place at Gladstone's new facility at UCSF's Mission Bay campus, will highlight promising avenues of Alzheimer's disease research being conducted in San Francisco and the greater Bay Area.

A half-hour tour of the Gladstone Institute of Neurological Disease will follow at 2:00 PM. This invitation-only symposium is intended for professionals in the field, including researchers, students and postdoctoral fellows. Journalists are also invited. The program is listed below.

"Gladstone brought Alzheimer's disease research to the Mission Bay campus with its move here last October," explains Gladstone Institute of Neurological Disease Director Dr. Lennart Mucke, who also holds the Joseph B. Martin Distinguished Professorship in Neuroscience at UCSF. "We are thrilled to co-host this exciting event. It will illustrate how current research can contribute to the development of better treatments. We also hope that it will foster further collaboration in this important field of research."

William Fisher, Alzheimer's Association chapter CEO for Northern California and Northern Nevada, says, "We're pleased to join Gladstone in bringing together some of our nation's leaders in Alzheimer research."

The Alzheimer's Association is the nation's largest private donor of Alzheimer research. Since its founding 25 years ago, it has awarded -- through its peer-review process -- $165 million to nearly 1,400 projects, including research in the greater Bay Area.

The Gladstone Institute of Neurological Disease is one of three research institutes of The J. David Gladstone Institutes, a private, nonprofit biomedical research institution affiliated with UCSF.

PROGRAM - BAY AREA ALZHEIMER'S DISEASE RESEARCH SYMPOSIUM

9:00 WELCOME AND INTRODUCTION: William Fisher, CEO, Alzheimer's Association, Northern California and Northern Nevada

9:15 NEW CLINICAL APPROACHES TO DEMENTIA: Dr. Bruce Miller, Director, UCSF Memory & Aging Center and Alzheimer's Disease Research Center, A.W. & Mary Margaret Clausen Distinguished Professor of Neurology, UCSF

9:30 NEURONAL DEFICITS CAUSED BY AMYLOID PROTEINS: DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS FOR ALZHEIMER'S DISEASE Dr. Lennart Mucke, Director, Gladstone Institute of Neurological Disease, Joseph B. Martin Distinguished Professor of Neuroscience, UCSF

9:45 APOLIPOPROTEIN E4 AND ALZHEIMER'S DISEASE: THERAPEUTIC TARGETS Dr. Robert Mahley, President, The J. David Gladstone Institutes, Professor of Pathology and Medicine, UCSF

10:00 TARGETING INFLAMMATION IN ALZHEIMER'S DISEASE Li Gan, Staff Research Investigator, Gladstone Institute of Neurological Disease, Assistant Professor of Neurology, UCSF

10:15 AN APP-MEDIATED CELL DEATH PATHWAY AND ITS ROLE IN ALZHEIMER'S DISEASE Dr. Dale Bredesen, and President, Buck Institute for Age Research, Professor of Neurology, UCSF

10:30 SLEEP AND CIRCADIAN RHYTHM DISORDERS IN ALZHEIMER'S DISEASE Dr. Jerome Yesavage, Director, Alzheimer's Disease Center, Professor of Psychiatry and Behavioral Sciences, Stanford University

10:45 Break

11:00 NGF TRAFFICKING AND SIGNALING: A WINDOW INTO ALZHEIMER BIOLOGY IN DOWN'S SYNDROME Chengbiao Wu, Senior Research Scientist, Department of Neurology and Neurological Sciences, Stanford University

11:15 TARGETED INHIBITION OF NEURONAL TGF SIGNALING PROMOTES ALZHEIMER-LIKE DISEASE IN VIVO Ina Tesseur, Instructor, Department of Neurology and Neurological Sciences, Stanford University

11:30 DIFFERENT MECHANISMS OF EPISODIC MEMORY FAILURE IN MILD COGNITIVE IMPAIRMENT Charles DeCarli, Director, Alzheimer's Disease Center, Professor of Neurology, UC Davis

11:45 DISCONNECTION OF WORKING MEMORY PROCESSES BY CEREBROVASCULAR DISEASE Adriane Mayda, Graduate Student, Neuroscience Program, UC Davis

12:00 KATHRYN GRUPE AWARDS FOR ALZHEIMER RESEARCH Elizabeth Edgerly, Program Director, Alzheimer's Association, Northern California and Northern California. The Kathryn Grupe Awards for Excellence in Research on Alzheimer's Disease and Related Disorders are selected annually from students and post-docs nominated from Northern California and Northern Nevada educational institutions. Finalists are chosen by the Medical and Scientific Advisory Council of the Alzheimer's Association chapter.

1:00 Luncheon

2:00 TOUR OF THE GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE - Led by Lennart Mucke and colleagues.

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