Summer 2011

Pomerantz Lab Focuses on Tissue Regeneration

The laboratory of Assistant Professor Jason Pomerantz, M.D., a plastic and reconstructive surgeon, has joined the UCSF Craniofacial and Mesenchymal Biology (CMB) Program in its new facilities on the Parnassus campus.

Pomerantz, who joined the UCSF faculty in 2009, is a physician-scientist whose research focuses on tissue regeneration. He seeks to understand how different regenerative capacities arose among species such as salamanders, and hopes to develop new approaches to repair and regenerate human tissues.

Jason Pomerantz

"My basic research focuses on developing new ways to treat defects in form and function, particularly for conditions for which there are no good medical or surgical solutions, such as amputated limbs or severe congenital facial defects," Pomerantz, a plastic and reconstructive surgeon, said.

His current research investigates ways to temporarily alter gene expression to mimic other species' potent regenerative mechanisms. Pomerantz is a plastic surgeon, specializing in pediatric and reconstructive surgery, including treatment of craniofacial anomalies.

Professor William Hoffman, M.D., chief of Plastic and Reconstructive Surgery, said, "It's people like Jason who will make the difference, because you have to have one foot in the clinical arena and one foot in the lab to conduct true translational research."

In his new state-of-the-art lab, Pomerantz is working next to colleagues from the medical and dental schools who are also investigating craniofacial and mesenchymal problems. "It fosters interaction and collaboration with other labs with complementary interests and expertise," Pomerantz said.

The Craniofacial and Mesenchymal Biology Program is based in the UCSF School of Dentistry, and is directed by Assistant Professor Ophir Klein, M.D., Ph.D., in Orofacial Sciences and Pediatrics.

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