Owen Wolkowitz, MD

Director, Psychopharmacology Assessment Clinic at Langley Porter Psychiatric Institute

Dr. Owen Wolkowitz directs the Psychopharmacology Assessment Clinic at the Langley Porter Psychiatric Institution. The clinic offers "second opinion" consultations to doctors treating patients with depression and anxiety disorders. Wolkowitz also is a lecturer on psychopharmacology and a researcher studying how stress and hormones affect the brain. Wolkowitz is certified by the American Board of Psychiatry and Neurology.

Academic Title


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University of Maryland School of Medicine 1979


Stanford Hospital and Clinics, Psychiatry 1983


National Institute of Mental Health, Psychopharmacology 1986

Selected Research and Publications

  1. Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM. Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity. Psychiatry Res. 2017 Dec; 258:330-336.
  2. Aschbacher K, Mellon SH, Wolkowitz OM, Henn-Haase C, Yehuda R, Flory JD, Bierer LM, Abu-Amara D, Marmar CR, Mueller SG. Posttraumatic stress disorder, symptoms, and white matter abnormalities among combat-exposed veterans. Brain Imaging Behav. 2017 Aug 19.
  3. Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM. Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings. J Psychosom Res. 2017 Aug; 99:177-180.
  4. Steenkamp LR, Hough CM, Reus VI, Jain FA, Epel ES, James SJ, Morford AE, Mellon SH, Wolkowitz OM, Lindqvist D. Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder. J Affect Disord. 2017 Sep; 219:193-200.
  5. Blessing EM, Reus V, Mellon SH, Wolkowitz OM, Flory JD, Bierer L, Lindqvist D, Dhabhar F, Li M, Qian M, Abu-Amara D, Galatzer-Levy I, Yehuda R, Marmar CR. Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans. Psychoneuroendocrinology. 2017 Aug; 82:91-97.
  6. Verhoeven JE, Révész D, Picard M, Epel EE, Wolkowitz OM, Matthews KA, Penninx BW, Puterman E. Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study. Mol Psychiatry. 2017 Mar 28.
  7. Hough CM, Lindqvist D, Epel ES, Denis MS, Reus VI, Bersani FS, Rosser R, Mahan L, Burke HM, Wolkowitz OM, Mellon SH. Higher serum DHEA concentrations before and after SSRI treatment are associated with remission of major depression. Psychoneuroendocrinology. 2017 Mar; 77:122-130.
  8. Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH. Oxidative stress, inflammation and treatment response in major depression. Psychoneuroendocrinology. 2017 Feb; 76:197-205.
  9. Verhoeven JE, Lin J, Révész D, Wolkowitz OM, Penninx BW. Unresolved Issues in Longitudinal Telomere Length Research: Response to Susser et al. Am J Psychiatry. 2016 Nov 01; 173(11):1147-1149.
  10. Wolkowitz OM, Jeste DV, Martin AS, Lin J, Daly RE, Reuter C, Kraemer H. Leukocyte telomere length: Effects of schizophrenia, age, and gender. J Psychiatr Res. 2017 Feb; 85:42-48.
  11. Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM. Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study. Brain Behav Immun. 2017 Jan; 59:260-264.
  12. Darrow SM, Verhoeven JE, Révész D, Lindqvist D, Penninx BW, Delucchi KL, Wolkowitz OM, Mathews CA. The Association Between Psychiatric Disorders and Telomere Length: A Meta-Analysis Involving 14,827 Persons. Psychosom Med. 2016 Sep; 78(7):776-87.
  13. Jin RO, Mason S, Mellon SH, Epel ES, Reus VI, Mahan L, Rosser RL, Hough CM, Burke HM, Mueller SG, Wolkowitz OM. Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls. Psychoneuroendocrinology. 2016 Oct; 72:139-46.
  14. Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM. Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report. Mol Neuropsychiatry. 2016 Jul; 2(2):88-96.
  15. Lee EE, Eyler LT, Wolkowitz OM, Martin AS, Reuter C, Kraemer H, Jeste DV. Elevated plasma F2-isoprostane levels in schizophrenia. Schizophr Res. 2016 Oct; 176(2-3):320-326.
  16. Mellon SH, Wolkowitz OM, Schonemann MD, Epel ES, Rosser R, Burke HB, Mahan L, Reus VI, Stamatiou D, Liew CC, Cole SW. Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment. Transl Psychiatry. 2016 May 24; 6:e821.
  17. Bersani FS, Wolkowitz OM, Milush JM, Sinclair E, Eppling L, Aschbacher K, Lindqvist D, Yehuda R, Flory J, Bierer LM, Matokine I, Abu-Amara D, Reus VI, Coy M, Hough CM, Marmar CR, Mellon SH. A population of atypical CD56(-)CD16(+) natural killer cells is expanded in PTSD and is associated with symptom severity. Brain Behav Immun. 2016 Aug; 56:264-70.
  18. Verhoeven JE, van Oppen P, Révész D, Wolkowitz OM, Penninx BW. Depressive and Anxiety Disorders Showing Robust, but Non-Dynamic, 6-Year Longitudinal Association With Short Leukocyte Telomere Length. Am J Psychiatry. 2016 Jun 01; 173(6):617-24.
  19. Henje Blom E, Han LK, Connolly CG, Ho TC, Lin J, LeWinn KZ, Simmons AN, Sacchet MD, Mobayed N, Luna ME, Paulus M, Epel ES, Blackburn EH, Wolkowitz OM, Yang TT. Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder. Transl Psychiatry. 2015 Nov 10; 5:e676.
  20. Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM. Association of dimensional psychological health measures with telomere length in male war veterans. J Affect Disord. 2016 Jan 15; 190:537-542.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.