Myoglobin — Serum

Definition

The myoglobin blood test measures the level of the protein myoglobin in the blood.

Myoglobin can also be measured with a urine test.

Alternative Names

Serum myoglobin; Heart attack - myoglobin blood test; Myositis - myoglobin blood test; Rhabdomyolysis - myoglobin blood test

How the Test is Performed

A blood sample is needed.

How to Prepare for the Test

No special preparation is needed.

How the Test will Feel

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

Why the Test is Performed

Myoglobin is a protein in heart and skeletal muscles. When you exercise, your muscles use up available oxygen. Myoglobin has oxygen attached to it, which provides extra oxygen for the muscles to keep at a high level of activity for a longer period.

When muscle is damaged, myoglobin in muscle cells is released into the bloodstream. The kidneys help remove myoglobin from the blood into the urine. When the level of myoglobin is too high, it can damage the kidneys.

This test is ordered when your health care provider suspects you have muscle damage, such as of the heart or skeletal muscle.

Normal Results

The normal range is 25 to 72 ng/mL (1.28 to 3.67 nmol/L).

Note: Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different samples. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

An increased level of myoglobin may be due to:

  • Heart attack
  • Malignant hyperthermia (very rare)
  • Disorder that causes muscle weakness and loss of muscle tissue (muscular dystrophy)
  • Breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood (rhabdomyolysis)
  • Skeletal muscle inflammation (myositis)
  • Skeletal muscle ischemia (oxygen deficiency)
  • Skeletal muscle trauma

Risks

There is very little risk involved with having your blood taken. Veins and arteries vary in size from one person to another, and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight, but may include:

  • Excessive bleeding
  • Fainting or feeling lightheaded
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)

References

Chernecky CC, Berger BJ. Myoglobin - serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:808-809.

Nagaraju K, Gladue HS, Lundberg IE. Inflammatory diseases of muscle and other myopathies. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelly and Firestein's Textbook of Rheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017:chap 85.

Selcen D. Muscle diseases. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 421.

Review Date: 2/13/2017

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