Pulmonary Hypertension

Pulmonary Hypertension

Signs and Symptoms
Diagnosis
Treatment

Signs and Symptoms

Pulmonary hypertension is a rare condition of high blood pressure in the blood vessels of the lungs as a result of various disorders. The pressure in the pulmonary artery leading from the right side of heart to the lungs rises above normal levels and imposes a big strain on the right side of the heart. The right side of the heart can become so enlarged and weakened that it eventually fails leading to poor quality of life and death.

Pulmonary hypertension is classified into five different types:

• Pulmonary Arterial Hypertension (PAH) -- This form affects the blood vessels in the lungs that carry blood from the heart into the lungs where it picks up oxygen. This category is subdivided into two types:
  

  • Primary pulmonary hypertension (PPH), which can occur for no discernable reason or - in about 10 percent of cases - is inherited. It is very rare. It most often occurs in young adults and is more than twice as common in women as men
  • PAH related to exposure to toxins including diet drugs such as fenphen; street drugs including cocaine and methamphetamine; HIV; collagen vascular diseases including scleroderma, lupus and rheumatoid arthritis; chronic liver disease; and congenital heart diseases.

• Pulmonary Venous Hypertension (PVH) -- This form is caused by diseases of the left side of the heart, such as heart failure or mitral valve disease. This can increase pulmonary artery blood pressure but usually doesn't become severe PAH.

• Respiratory System -- Pulmonary hypertension can be associated with diseases of the respiratory system including interstitial lung disease, emphysema, asthmatic bronchitis, sleep apnea and chronic exposure to high altitude.

• Chronic Blood Clots -- Blood clots in the lung blood vessels

• Blood Vessel Disorders -- Pulmonary hypertension due to disorders directly affecting the blood vessels in the lungs such as parasites, or inflammation of the blood vessels.

There are no specific signs and symptoms in the early stages of the disease. The symptoms that may occur -- such as shortness of breath, fatigue and chest pain -- also are common to many other conditions. Other symptoms that may occur include dizziness, swollen ankles and legs, fainting and a bluish cast to lips and skin.

Over time, pulmonary arterial hypertension can damage your heart to the point of danger and result in complications that can interfere with your daily life. Complications from pulmonary hypertension include:

• Enlarged right ventricle
• Blood clots

Reviewed by health care specialists at UCSF Medical Center.
Last updated May 8, 2007