Methotrexate is part of a class of drugs called immunosuppressants. It suppresses the body's immune response and reduces inflammation in your lungs. Because inflammation is the precursor to fibrosis (scarring), we hope methotrexate will prevent the formation of lung fibrosis and allow the inflamed lung to return to normal.
Before taking methotrexate:
Your doctor may need to change the doses of your medication or monitor you more carefully for side effects.
Methotrexate may cause side effects. Tell your doctor if any of the following symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of the following symptoms or any symptoms listed in the important warning section of the medication insert, call your doctor immediately:
Methotrexate may cause other side effects. Tell your doctor if you have any unusual problems while you are taking this medication.
Your doctor will order regular lab tests to check your response to methotrexate and monitor for toxicity. You will need to have your blood counts — white blood cells, red blood cells and platelets — and liver function checked regularly. Your doctor may order additional tests depending on the results.
For additional information on methotrexate, please visit MedlinePlus.gov.
Reviewed by health care specialists at UCSF Medical Center.
This information is for educational purposes only and is not intended to replace the advice of your doctor or health care provider. We encourage you to discuss with your doctor any questions or concerns you may have.
Interstitial Lung Disease Program
400 Parnassus Ave., Fifth Floor
San Francisco, CA 94143
Phone: (415) 353-2577
Fax: (415) 353-2568