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Michael D. Geschwind, Ph.D., M.D.

Neurologist

Dr. Michael D. Geschwind is a neurologist at the UCSF Memory and Aging Center who specializes in the assessment and treatment of rapidly progressive dementias, including prion diseases such as Creutzfeldt-Jakob disease (CJD). He helped established a hospital program for the assessment of rapidly progressive dementias at UCSF Medical Center, the first of its kind in the country. In his research, he studies cognitive dysfunction in movement disorders, such as Huntington's disease, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP) and other Parkinsonian dementias.

Geschwind earned his medical degree and postdoctoral degree in neuroscience through the Medical Scientist Training Program, sponsored by the National Institutes of Health, at the Albert Einstein College of Medicine in New York. He completed an internship in internal medicine at UCLA Medical Center, a neurology residency at the Johns Hopkins University School of Medicine in Baltimore and a fellowship in behavioral neurology at the UCSF Memory and Aging Center. He is an associate professor of neurology and holds the Michael J. Homer Chair in Neurology in the UCSF School of Medicine.

Conditions & Treatments

Clinics

Memory and Aging Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 476-6880
Fax: (415) 476-4800

Hours: Monday to Friday
8 a.m. – 5 p.m.

More about Michael D. Geschwind

Additional Languages

French

Education

Albert Einstein College of Medicine 1996

Residencies

John Hopkins Hospital, Neurology 2000

Fellowships

UCSF Medical Center, Neurobehavior 2002

Selected Research and Publications

  1. Tartaglia MC, Johnson DY, Thai JN, Cattaruzza T, Wong K, Garcia P, Dearmond SJ, Miller BL, Geschwind MD. Clinical Overlap between Jakob-Creutzfeldt Disease and Lewy Body Disease. Can J Neurol Sci. 2012 May; 39(3):304-10.
  2. Kim EJ, Cho SS, Jeong BH, Kim YS, Seo SW, Na DL, Geschwind MD, Jeong Y. Glucose metabolism in sporadic Creutzfeldt-Jakob disease: a statistical parametric mapping analysis of (18) F-FDG PET. Eur J Neurol. 2012 Mar; 19(3):488-93.
  3. Perry DC, Geschwind MD. Thorough work-up and new diagnostic criteria needed for CJD. Nat Rev Neurol. 2011 Sep; 7(9):479-80.
  4. Sloan JL, Johnston JJ, Manoli I, Chandler RJ, Krause C, Carrillo-Carrasco N, Chandrasekaran SD, Sysol JR, O'Brien K, Hauser NS, Sapp JC, Dorward HM, Huizing M. Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria. Nat Genet. 2011 Sep; 43(9):883-6.
  5. Lee SE, Rabinovici GD, Mayo MC, Wilson SM, Seeley WW, DeArmond SJ, Huang EJ, Trojanowski JQ, Growdon ME, Jang JY, Sidhu M, See TM, Karydas AM, Gorno-Tempini ML, Boxer AL, Weiner MW, Geschwind MD, Rankin KP, Miller BL. Clinicopathological correlations in corticobasal degeneration. Ann Neurol. 2011 Aug; 70(2):327-40.
  6. Vitali P, Maccagnano E, Caverzasi E, Henry RG, Haman A, Torres-Chae C, Johnson DY, Miller BL, Geschwind MD. Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias. Neurology. 2011 May 17; 76(20):1711-9.
  7. Tartaglia MC, Thai JN, See T, Kuo A, Harbaugh R, Raudabaugh B, Cali I, Sattavat M, Sanchez H, DeArmond SJ, Geschwind MD. Pathologic evidence that the T188R mutation in PRNP is associated with prion disease. J Neuropathol Exp Neurol. 2010 Dec; 69(12):1220-7.
  8. Zou WQ, Puoti G, Xiao X, Yuan J, Qing L, Cali I, Shimoji M, Langeveld JP, Castellani R, Notari S, Crain B, Schmidt RE, Geschwind M, Dearmond SJ, Cairns NJ, Dickson D, Honig L, Torres JM, Mastrianni J, Capellari S, Giaccone G, Belay ED, Schonberger LB, Cohen M, Perry G, Kong Q, Parchi P, Tagliavini F, Gambetti P. Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein. Ann Neurol. 2010 Aug; 68(2):162-72.
  9. Benetti F, Geschwind MD, Legname G. De novo prions. F1000 Biol Rep. 2010; 2.
  10. Yang TI, Jung DS, Ahn BY, Jeong BH, Cho HJ, Kim YS, Na DL, Geschwind MD, Kim EJ. Familial Creutzfeldt-Jakob disease with V180I mutation. J Korean Med Sci. 2010 Jul; 25(7):1097-100.
  11. Geschwind MD. Are you related to "the Geschwind?". Neuropsychol Rev. 2010 Jun; 20(2):123-5.
  12. Kieburtz K, McDermott MP, Voss TS, Corey-Bloom J, Deuel LM, Dorsey ER, Factor S, Geschwind MD, Hodgeman K, Kayson E, Noonberg S, Pourfar M, Rabinowitz K, Ravina B, Sanchez-Ramos J, Seely L, Walker F, Feigin A. A randomized, placebo-controlled trial of latrepirdine in Huntington disease. Arch Neurol. 2010 Feb; 67(2):154-60.
  13. Barajas RF, Collins DE, Cha S, Geschwind MD. Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody. Epilepsia. 2010 Mar; 51(3):473-7.
  14. Rosenbloom MH, Smith S, Akdal G, Geschwind MD. Immunologically mediated dementias. Curr Neurol Neurosci Rep. 2009 Sep; 9(5):359-67.
  15. Choi EM, Geschwind MD, Deering C, Pomeroy K, Kuo A, Miller BL, Safar JG, Prusiner SB. Prion proteins in subpopulations of white blood cells from patients with sporadic Creutzfeldt-Jakob disease. Lab Invest. 2009 Jun; 89(6):624-35.
  16. Lai M, Hughes EG, Peng X, Zhou L, Gleichman AJ, Shu H, Matà S, Kremens D, Vitaliani R, Geschwind MD, Bataller L, Kalb RG, Davis R, Graus F, Lynch DR, Balice-Gordon R, Dalmau J. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009 Apr; 65(4):424-34.
  17. Geschwind MD. Clinical trials for prion disease: difficult challenges, but hope for the future. Lancet Neurol. 2009 Apr; 8(4):304-6.
  18. Geschwind MD, Potter CA, Sattavat M, Garcia PA, Rosen HJ, Miller BL, DeArmond SJ. Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease. Alzheimer Dis Assoc Disord. 2009 Jan-Mar; 23(1):82-87.
  19. Vitali P, Migliaccio R, Agosta F, Rosen HJ, Geschwind MD. Neuroimaging in dementia. Semin Neurol. 2008 Sep; 28(4):467-83.
  20. Geschwind MD, Tan KM, Lennon VA, Barajas RF, Haman A, Klein CJ, Josephson SA, Pittock SJ. Voltage-gated potassium channel autoimmunity mimicking creutzfeldt-jakob disease. Arch Neurol. 2008 Oct; 65(10):1341-6.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.